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RHPN2 encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins.
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We found significant association between RHPN2 gene rs10411210 and colorectal cancer in European and Asian populations, but not American population
Single nucleotide polymorphism in RHPN2 gene is associated with colorectal cancer.
These effects were implemented through RHPN2-mediated activation of RhoA (zeige RHOA Proteine).
Rhophilin-2 may function normally in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA (zeige RHOA Proteine) activity
may play a key role between RhoB and potential downstream elements needed under stimulation of the thyrotropin/cAMP pathway in thyrocytes
Mice lacking rhophilin 2 develop normally, have normal life spans, and are fertile; rhophilin 2 does not play an essential role in thyroid physiology
This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton.
76 kDa RhoB effector protein
, GTP-Rho-binding protein 2
, rhophilin 2
, rhophilin-like Rho-GTPase binding protein
, Rho GTPase binding protein 2
, p76RBE protein