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Receptor for RNL3/relaxin-3. Zusätzlich bieten wir Ihnen Relaxin 3 Receptor 1 Antikörper (85) und Relaxin 3 Receptor 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Results indicate endogenous RLN3/RXFP3 signaling can modulate hippocampal-dependent spatial reference and working memory via effects on somatostatin interneurons, and further our knowledge of hippocampal cognitive processing
we investigated the effect of Rxfp3 gene deletion in C57BL/6J mice on sucrose and alcohol self-administration and cue-induced reinstatement (RNST) of sucrose- and alcohol-seeking.
Rxfp3 KO mice displayed a stress-induced reduction in alcohol preference that was not observed in WT littermates.
This study demonstrated that Relaxin-3 receptor (Rxfp3) gene knockout mice display reduced running wheel activity: implications for role of relaxin-3/RXFP3 signalling in sustained arousal.
These findings are consistent with an earlier report of increased activity scores in rats acutely injected centrally with R3/I5, and further suggest a role for relaxin-3/RXFP3 signalling in promoting behavioural arousal.
Central injection of the RXFP3 agonists R3/I5 or H3 relaxin (0.5 nmol, icv) did not alter chow consumption in satiated mice relative to vehicle controls, during the 60 min after treatment.
Data provide evidence for the conserved nature of RLN3/RXFP3 systems in mammalian brain and the ability of RLN3/RXFP3 signaling to modulate "behavioral state" and an array of circuits involved in arousal, stress, affect, and cognition.
A distinct pattern of expression in brain, spinal cord, and dorsal root ganglia during development and in the mature brain hint at important functions of SALPR for differentiation and maintenance of the nervous system.(SALPR PROTEIN, MOUSE)
This study indicated that RXFP3 mainly localised in the post-acrosomal region of sperm head and neck.
The role of these four INSL5 determinants in distinguishing RXFP4 from RXFP3.
Therefore, we conclude that stapling of the relaxin3 B chain does not compromise its ability to activate RXFP3 and is a promising method for developing stable peptide agonists and antagonists of RXFP3 to aid relaxin-3/RXFP3 research.
the negatively charged transmembrane aspartate residue controls activation of the relaxin-3 receptor RXFP3
we demonstrated distinct patterns of signalling for H3 and H2 relaxin and R3(BDelta23-27)R/I5 at the RXFP3 receptor
Glu141 and Asp145 of the RXFP3 interact with the highly conserved arginine residues of relaxin-3.
demonstrate the existence of an allosteric site for modulation of RXFP3
H3 relaxin potently activates all signaling pathways coupled to RXFP3, whereas H2 relaxin is an AP-1-biased ligand relative to H3 relaxin.
Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors.
GPCR135 (SALPR) is the receptor for relaxin-3
Substitution of the relaxin-3 A-chain with the A-chain from insulin-like peptide 5 results in a chimeric peptide that selectively activates GPCR135 and GPCR142.
functional response to H3 relaxin and other relaxin/insulin peptides of GPCR135 expressed in CHO-K1 cells was measured in the cytosensor microphysiometer and analyzed using inhibitors of signal transduction proteins
analysis of truncated human relaxin-2 and -3 (H2 and H3) relaxin peptides and their binding and cAMP activities on RXFP1, RXFP2, and RXFP3
the N-terminus and EL2 domains of RXFP3 and RXFP4 are involved in ligand binding while TM2, 3, and 5 are critical for receptor activation.
Results decribe the structural and functional aspects of the interaction between relaxin-3 and its receptor, RXFP3.
Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation (By similarity).
relaxin/insulin-like family peptide receptor 3
, relaxin 3 receptor 1
, G-protein coupled receptor SALPR
, RLN3 receptor 1
, g protein-coupled receptor SALPR homolog
, relaxin-3 receptor 1
, relaxin-3/INSL7 receptor 1
, somatostatin and angiotensin-like peptide receptor
, G-protein coupled receptor GPCR135
, g protein-coupled receptor SALPR
, relaxin family peptide receptor 3
, somatostatin- and angiotensin-like peptide receptor