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RFX4 is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. Zusätzlich bieten wir Ihnen RFX4 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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The gene encoding the transcription factor RFX4 represents an excellent neurobiological and positional candidate gene for Bipolar disorder due to the potential involvement of RFX4 proteins in the regulation of circadian rhythms, linked to chromosome 12.
GPS2 (zeige GPS2 Antikörper) interacts with RFX4_v3 to modulate transactivation of genes involved in brain morphogenesis, including Cx3Cl1 (zeige CX3CL1 Antikörper)
provide a novel conditional KO animal model in which to investigate the downstream genes directly and/or indirectly regulated by RFX4 isoform 1. This model could provide new insights into the pathogenesis of obstructive hydrocephalus and holoprosencephaly in humans, both relatively common and disabling birth defects
the dominant Rfx4 transcript present begins at a downstream exon and lacks the DNA binding domain
mouse regulatory factor X4 transcript is expressed in the suprachiasmatic nucleus and regulated by light
Rfx4 is a regionally specific transcriptional regulator of ciliogenesis and thus is also a regionally specific modulator of Shh (zeige SHH Antikörper) signaling during development of the central nervous system.
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants.
transcription factor RFX4
, winged-helix transcription factor RFX4 variant 3
, testis development protein NYD-SP10
, winged-helix transcription factor RFX4
, regulatory factor X 4 protein
, regulatory factor X, 4 (influences HLA class II expression) isoform 1
, regulatory factor X, 4 (influences HLA class II expression) isoform 2