Regucalcin Proteine (RGN)

The protein encoded by RGN is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. Zusätzlich bieten wir Ihnen Regucalcin Antikörper (44) und Regucalcin Kits (19) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RGN 19733 Q64374
RGN 9104 Q15493
RGN 25106 Q03336
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Top Regucalcin Proteine auf

Showing 10 out of 17 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Ratte His-SUMO Tag   50 μg Anmelden zum Anzeigen 11 Days
Hefe Ratte His tag   50 μg Anmelden zum Anzeigen 8 bis 11 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

RGN Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
Human , ,
, ,
Rat (Rattus) ,
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Weitere Proteine zu Regucalcin (RGN) Interaktionspartnern

Zebrafish Regucalcin (RGN) Interaktionspartner

  1. SMP30/RGN is important for liver proliferation and tumorigenesis.

Mouse (Murine) Regucalcin (RGN) Interaktionspartner

  1. The phosphorylated eNOS (zeige NOS3 Proteine) and Akt (zeige AKT1 Proteine) levels and VEGF (zeige VEGFA Proteine) levels in ischemic muscle were lower in SMP30 KO and old mice than in young mice. Deficiency of SMP30 exacerbates oxidative stress related to NADPH oxidase (zeige NOX1 Proteine) activity enhancement and impairs eNOS (zeige NOS3 Proteine) activity, which leads to rarefaction of angiogenesis induced by ischemia

  2. Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt (zeige AKT1 Proteine) activation.

  3. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db (zeige LEPR Proteine) mice.

  4. SMP30/GNL-positive cells localized around the central veins of livers of mice and decreased numerically with aging. Nuclear SMP30/GNL protein might be a regulatory factor specific for genes whose expression governs transcription and the aging process.

  5. SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.

  6. SMP30 plays an important role in the regulation of coronary vascular tone by myocardium.

  7. These results suggested that SMP30 might be involved in overriding the apoptotic homeostatic mechanism in response to DNA damage.

  8. SMP30 deficiency is closely associated with non-alcoholic fatty liver disease pathogenesis.

  9. left ventricular ejection fraction was more severely reduced in the DOX-treated SMP30 KO mice than in the DOX-treated WT mice, but was preserved in the DOX-treated SMP30 TG mice

  10. Results from using this unique model of AA deficiency, the SMP30/GNL-KO mouse, now provide new information about formerly unknown AA functions that will implement further study of AA in vivo.

Human Regucalcin (RGN) Interaktionspartner

  1. These findings suggest that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucalcin expression may predispose patients to development of lung cancer.

  2. The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes. [review]

  3. High RGN expression is associated with hepatocellular carcinoma.

  4. the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 (zeige TP53 Proteine) and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome.

  5. Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways.

  6. Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase (zeige GLB1 Proteine) expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis.

  7. data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells.

  8. immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients

  9. results highlighted the importance of RGN as a regulatory protein in Ca2 (zeige CA2 Proteine)+-dependent signaling pathways and its deregulation of RGN expression by Ca2 (zeige CA2 Proteine)+o may contribute for onset and progression of PCa (zeige FLVCR1 Proteine).

  10. This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review]

Cow (Bovine) Regucalcin (RGN) Interaktionspartner

  1. estrogen administration down-regulated RGN gene expression in the accessory sex glands of veal calves and beef cattle, while androgen treatment reduced RGN gene expression only in the testis.

Regucalcin (RGN) Protein Überblick

Protein Überblick

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.

Genbezeichner und Symbole assoziert mit Regucalcin Proteine (RGN)

  • CG1803 gene product from transcript CG1803-RA (regucalcin)
  • regucalcin (rgn)
  • regucalcin (LOC465598)
  • regucalcin (RGN)
  • GE16489 gene product from transcript GE16489-RB (Dyak\regucalcin)
  • regucalcin (senescence marker protein-30) (RGN)
  • regucalcin (Rgn)
  • regucalcin L homeolog (rgn.L)
  • AI265316 Protein
  • CG1803 Protein
  • Dmel\\CG1803 Protein
  • DyakGE16489 Protein
  • dyak_GLEANR_17905 Protein
  • GE16489 Protein
  • GNL Protein
  • Rc Protein
  • Reguc Protein
  • regucalcin Protein
  • rgn-A Protein
  • SMP-30 Protein
  • SMP30 Protein
  • T1 Protein
  • xsmp-30 Protein
  • xsmp30 Protein
  • zgc:92078 Protein

Bezeichner auf Proteinebene für Regucalcin Proteine (RGN)

CG1803-PA , CG1803-PB , CG1803-PC , CG1803-PD , regucalcin-PA , regucalcin-PB , regucalcin-PC , regucalcin-PD , RC , gluconolactonase , regucalcin , regucalcin (senescence marker protein-30) , DyakGE16489-PA , Dyakregucalcin-PA , GE16489-PA , SMP-30 , senescence marker protein 30 , senescence marker protein-30 , xSMP-30

32165 Drosophila melanogaster
403070 Danio rerio
448549 Xenopus (Silurana) tropicalis
465598 Pan troglodytes
480893 Canis lupus familiaris
6523987 Drosophila yakuba
100060684 Equus caballus
100171395 Ovis aries
100174578 Pongo abelii
100196365 Salmo salar
100528098 Ictalurus punctatus
19733 Mus musculus
9104 Homo sapiens
395480 Gallus gallus
373659 Xenopus laevis
25106 Rattus norvegicus
768107 Sus scrofa
280910 Bos taurus
100008619 Oryctolagus cuniculus
Ausgewählte Anbieter für Regucalcin Proteine (RGN)
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