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The protein encoded by RGN is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. Zusätzlich bieten wir Ihnen Regucalcin Antikörper (44) und Regucalcin Proteine (17) und viele weitere Produktgruppen zu diesem Protein an.
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SMP30/RGN is important for liver proliferation and tumorigenesis.
The phosphorylated eNOS (zeige NOS3 ELISA Kits) and Akt (zeige AKT1 ELISA Kits) levels and VEGF (zeige VEGFA ELISA Kits) levels in ischemic muscle were lower in SMP30 KO and old mice than in young mice. Deficiency of SMP30 exacerbates oxidative stress related to NADPH oxidase (zeige NOX1 ELISA Kits) activity enhancement and impairs eNOS (zeige NOS3 ELISA Kits) activity, which leads to rarefaction of angiogenesis induced by ischemia
Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt (zeige AKT1 ELISA Kits) activation.
This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db (zeige LEPR ELISA Kits) mice.
SMP30/GNL-positive cells localized around the central veins of livers of mice and decreased numerically with aging. Nuclear SMP30/GNL protein might be a regulatory factor specific for genes whose expression governs transcription and the aging process.
SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.
SMP30 plays an important role in the regulation of coronary vascular tone by myocardium.
These results suggested that SMP30 might be involved in overriding the apoptotic homeostatic mechanism in response to DNA damage.
SMP30 deficiency is closely associated with non-alcoholic fatty liver disease pathogenesis.
left ventricular ejection fraction was more severely reduced in the DOX-treated SMP30 KO mice than in the DOX-treated WT mice, but was preserved in the DOX-treated SMP30 TG mice
Results from using this unique model of AA deficiency, the SMP30/GNL-KO mouse, now provide new information about formerly unknown AA functions that will implement further study of AA in vivo.
These findings suggest that regucalcin may play a potential role as a suppressor of human lung cancer, and that downregulation of regucalcin expression may predispose patients to development of lung cancer.
The role of RGN suppressing cell proliferation is associated with the regulation of expression of oncogenes and tumor suppressor genes. [review]
High RGN expression is associated with hepatocellular carcinoma.
the present study suggests that regucalcin may have important anticancer properties in human breast cancer patients. Mechanistically, these effects are likely mediated through suppression of multiple signaling pathways, upregulation of p53 (zeige TP53 ELISA Kits) and downregulation of oncogenes leading to anti-proliferative effects and reduced metastases to bone, a phenotype associated with poor clinical outcome.
Study demonstrates that increased regucalcin gene expression greatly contributes to prolonged survival in human pancreatic cancer patients. Morover, overexpression of regucalcin was found to suppress the proliferation, which is enhanced through various signaling pathways.
Study results suggest that senescence marker protein-30 and senescence-associated beta-galactosidase (zeige GLB1 ELISA Kits) expressions in both nuclear cataract and cortical cataract patients were associated with lens epithelial cells apoptosis.
data suggest that exogenous regucalcin exerts suppressive effects on the proliferation of human pancreatic cancer cells.
immunohistochemistry revealed a significant decrease of regucalcin in human kidney disease tissue vs control kidney tissue, and regucalcin was detected in exosomes isolated from healthy donors' urine but not from kidney disease patients
results highlighted the importance of RGN as a regulatory protein in Ca2 (zeige CA2 ELISA Kits)+-dependent signaling pathways and its deregulation of RGN expression by Ca2 (zeige CA2 ELISA Kits)+o may contribute for onset and progression of PCa (zeige FLVCR1 ELISA Kits).
This review will discuss regarding to an involvement of regucalcin as a suppressor protein in human carcinogenesis in insight into the gene therapy. [review]
estrogen administration down-regulated RGN gene expression in the accessory sex glands of veal calves and beef cattle, while androgen treatment reduced RGN gene expression only in the testis.
The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
, regucalcin (senescence marker protein-30)
, senescence marker protein 30
, senescence marker protein-30