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The protein encoded by RECQL5 is a helicase that is important for genome stability.
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we have shown that increased expression of RECQL5 protein occurs and is likely to contribute to tumourigenesis in UCC and that the pharmacological targeting of the helicase activity of RECQL5 is a strong target for future small molecule inhibitor development.
RECQ5 removes RAD51 filaments stabilizing stalled replication forks at common fragile sites and hence facilitates CFS cleavage by MUS81-EME1.
the open and closed forms of RECQL5 were used together with a quantitative comparison of all current RecQ family structures to construct a mechanistic model for RECQL5 helicase activity
Study characterized the G-quadruplex (GQ) unfolding activity of RECQ5 for different DNA constructs under different salt conditions, showed that RECQ5 is overall a weak GQ destabilizer compared to Bloom and Werner
interaction between RECQ5 and proliferating cell nuclear antigen (PCNA (zeige PCNA Proteine)) promotes RAD18 (zeige RAD18 Proteine)-dependent PCNA (zeige PCNA Proteine) ubiquitination and the helicase activity of RECQ5 promotes the processing of replication intermediates.
RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins
RECQL5 is a critical regulator of genome stability in myeloproliferative neoplasms and demonstrate that replication stress-associated cytotoxicity can be amplified specifically in JAK2V617F mutant cells through RECQL5-targeted synthetic lethality.
Expression of RECQL5 in breast cancer can drive proliferation supporting an oncogenic function for RECQL5 in breast cancer. RECQL5 is a promising biomarker in breast cancer.
RecQ5 prevents transcription associated genome instability by facilitating PIAS1 (zeige PIAS1 Proteine)-SRSF1 (zeige SRSF1 Proteine) ligase complex sumoylation of DNA topoisomerase 1 (zeige TOP1 Proteine).
results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment
Recql5 protects the liver against LPS (zeige TLR4 Proteine)/D-Gal (zeige GAL Proteine)-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.
Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc (zeige APC Proteine)(min) mice.
Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (
Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I (zeige TOP1 Proteine) poisoning.
The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.
ATP-dependent DNA helicase Q5
, RecQ protein-like 5
, ATP-dependent DNA helicase Q5-like
, DNA helicase, RecQ-like type 5