RecQ Protein-Like 5 Proteine (RECQL5)

The protein encoded by RECQL5 is a helicase that is important for genome stability. Zusätzlich bieten wir Ihnen RECQL5 Antikörper (56) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RECQL5 9400 O94762
RECQL5 170472  
Ratte RECQL5 RECQL5 287834  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

RECQL5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu RecQ Protein-Like 5 (RECQL5) Interaktionspartnern

Human RecQ Protein-Like 5 (RECQL5) Interaktionspartner

  1. It has been shown that conjugation of SUMO2, but not SUMO1 or SUMO3, to the essential replication factor PCNA is induced on transcribed chromatin by the RNAPII-bound helicase RECQ5.

  2. we have shown that increased expression of RECQL5 protein occurs and is likely to contribute to tumourigenesis in UCC and that the pharmacological targeting of the helicase activity of RECQL5 is a strong target for future small molecule inhibitor development.

  3. RECQ5 removes RAD51 filaments stabilizing stalled replication forks at common fragile sites and hence facilitates CFS cleavage by MUS81-EME1.

  4. the open and closed forms of RECQL5 were used together with a quantitative comparison of all current RecQ family structures to construct a mechanistic model for RECQL5 helicase activity

  5. Study characterized the G-quadruplex (GQ) unfolding activity of RECQ5 for different DNA constructs under different salt conditions, showed that RECQ5 is overall a weak GQ destabilizer compared to Bloom and Werner

  6. interaction between RECQ5 and proliferating cell nuclear antigen (PCNA) promotes RAD18-dependent PCNA ubiquitination and the helicase activity of RECQ5 promotes the processing of replication intermediates.

  7. RECQL5 has unique strand annealing properties relative to the other human RecQ helicase proteins

  8. RECQL5 is a critical regulator of genome stability in myeloproliferative neoplasms and demonstrate that replication stress-associated cytotoxicity can be amplified specifically in JAK2V617F mutant cells through RECQL5-targeted synthetic lethality.

  9. mutation associated with early myocardial infarction

  10. Expression of RECQL5 in breast cancer can drive proliferation supporting an oncogenic function for RECQL5 in breast cancer. RECQL5 is a promising biomarker in breast cancer.

  11. RecQ5 prevents transcription associated genome instability by facilitating PIAS1-SRSF1 ligase complex sumoylation of DNA topoisomerase 1.

  12. results suggested RECQL5 as a tumor suppressor in osteosarcoma and may be a potential therapeutic target for osteosarcoma treatment

  13. PARylation is involved in the recruitment of RECQL5 and WRN to laser-induced DNA damage and RECQL5 and WRN have differential responses to PARylated PARP1 and Poly(ADP-ribose).

  14. The RECQL5 genetic polymorphism was associated with osteosarcoma in a Chinese population.

  15. The present study indicated that the RECQL5 genetic polymorphism and haplotypes were associated with breast cancer in a Chinese population.

  16. RECQL5 as a major determinant for camptothecin resistance in colorectal cancer cells.

  17. The data presented here provide evidence that RECQL5 plays a general role in the control of transcript elongation in human cells. In its absence, transcript elongation rates increase, the distribution profile of RNAPII is markedly altered across the genome, and higher levels of RNAPII pausing or arrest (i.e., transcription stress) are detected.

  18. RECQL5 genetic polymorphisms were associated with osteosarcoma in a Chinese population.

  19. The present study indicated that RECQL5 genetic polymorphism and haplotypes were associated with larynx cancer in a Chinese population.

  20. The findings suggest that RECQ5 acts during the post-synaptic phase of synthesis-dependent strand annealing to prevent formation of aberrant RAD51 filaments on the extended invading strand, thus limiting its channeling into potentially hazardous crossover pathway of homologous recombination.

Mouse (Murine) RecQ Protein-Like 5 (RECQL5) Interaktionspartner

  1. Recql5 protects the liver against LPS/D-Gal-induced injury by suppressing hepatocyte apoptosis and oxidative stress and modulation of CYP450 expression.

  2. Recql5 has a tumor suppressor role in the gastrointestinal tract of Apc(min) mice.

  3. Recql5-deficient cells exhibit elevated frequencies of spontaneous DNA double-strand breaks and homologous recombination (

  4. Data suggest that Recql5 helps maintain active DNA replication to prevent collapse of replication forks and accumulation of DSBs, preserve genome integrity and prevent cell death after replication stress due to topoisomerase I poisoning.

RECQL5 Protein Überblick

Protein Überblick

The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit RecQ Protein-Like 5 Proteine (RECQL5)

  • RecQ like helicase 5 (RECQL5)
  • RecQ helicase-like 5 (recql5)
  • ATP-dependent DNA helicase Q5 (LOC100544199)
  • RecQ protein-like 5 (Recql5)
  • RecQ like helicase 5 (Recql5)
  • DKFZp459N0627 Protein
  • RECQ5 Protein
  • Recq5b Protein
  • Recql5b Protein

Bezeichner auf Proteinebene für RecQ Protein-Like 5 Proteine (RECQL5)

ATP-dependent DNA helicase Q5 , RecQ protein-like 5 , ATP-dependent DNA helicase Q5-like , DNA helicase, RecQ-like type 5

373891 Gallus gallus
454885 Pan troglodytes
566553 Danio rerio
702951 Macaca mulatta
100027279 Monodelphis domestica
100059566 Equus caballus
100173649 Pongo abelii
100216093 Xenopus (Silurana) tropicalis
100225598 Taeniopygia guttata
100397260 Callithrix jacchus
100469169 Ailuropoda melanoleuca
100544199 Meleagris gallopavo
9400 Homo sapiens
512590 Bos taurus
170472 Mus musculus
287834 Rattus norvegicus
483317 Canis lupus familiaris
100626380 Sus scrofa
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