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The protein encoded by RECQL is a member of the RecQ DNA helicase family. Zusätzlich bieten wir Ihnen RecQ Protein-Like (DNA Helicase Q1-Like) Antikörper (21) und viele weitere Produktgruppen zu diesem Protein an.
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Recql suppresses chromosomal instability.
Study detected five different RECQL mutation in six unrelated breast cancer patients. The identified mutations include one frame-shift deletion, two splicing site mutation and one nonsense mutation.
RECQ1 is significantly overexpressed in multiple myeloma cells vs normal plasma cells. Increased RECQ1 expression is associated with poor prognosis. Its knockdown inhibits cell growth, increases apoptosis, and promotes DNA ds-breaks. Its overexpression protects against melphalan and bortezomib. It interacts with PARP1 (zeige PARP1 Proteine) and its loss sensitizes to PARP inhibitors.
Data indicate that RECQL* c.1667_1667+3delAGTA is not a high-risk mutation for breast cancer though it could represent a moderate-risk breast cancer susceptibility allele.[meta-analysis]
The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1 (zeige ERCC1 Proteine)-XPF (zeige ERCC4 Proteine) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (zeige PARP1 Proteine) and RPA (zeige RPA1 Proteine).
We conclude that RECQL1 has prognostic and predictive significance in breast cancers.
Our results indicate that the zinc binding motif in the RQC domain of RECQ1 is a key structural element that is essential for the structure-functions of RECQ1.
Knockdown of RECQ1 significantly suppressed lung cancer cell proliferation, migration and invasion.
To better understand the roles of RECQ1, two AL mutants (W227A and F231A) in full-length RECQ1 were characterized biochemically and genetically
RECQL is a new breast cancer susceptibility gene.
RECQL is a DNA helicase in breast cancer [editorial]
The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.
ATP-dependent DNA helicase Q1
, RecQ protein-like (DNA helicase Q1-like)
, ATP-dependent DNA helicase Q1-like
, DNA-dependent ATPase Q1
, recQ protein-like 1
, DNA helicase, RecQ-like type 1