RecQ Protein-Like (DNA Helicase Q1-Like) Proteine (RECQL)

The protein encoded by RECQL is a member of the RecQ DNA helicase family. Zusätzlich bieten wir Ihnen RecQ Protein-Like (DNA Helicase Q1-Like) Antikörper (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RECQL 19691 Q9Z129
RECQL 5965 P46063
RECQL 312824 Q6AYJ1
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Top RecQ Protein-Like (DNA Helicase Q1-Like) Proteine auf

Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

RECQL Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Weitere Proteine zu RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) Interaktionspartnern

Mouse (Murine) RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) Interaktionspartner

  1. Recql suppresses chromosomal instability.

Human RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) Interaktionspartner

  1. Study detected five different RECQL mutation in six unrelated breast cancer patients. The identified mutations include one frame-shift deletion, two splicing site mutation and one nonsense mutation.

  2. RECQ1 is significantly overexpressed in multiple myeloma cells vs normal plasma cells. Increased RECQ1 expression is associated with poor prognosis. Its knockdown inhibits cell growth, increases apoptosis, and promotes DNA ds-breaks. Its overexpression protects against melphalan and bortezomib. It interacts with PARP1 (zeige PARP1 Proteine) and its loss sensitizes to PARP inhibitors.

  3. Data indicate that RECQL* c.1667_1667+3delAGTA is not a high-risk mutation for breast cancer though it could represent a moderate-risk breast cancer susceptibility allele.[meta-analysis]

  4. The authors have discovered a major sub-pathway of conventional long-patch base excision repair that involves formation of a 9-nucleotide gap 5' to the lesion. This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1 (zeige ERCC1 Proteine)-XPF (zeige ERCC4 Proteine) endonuclease in cooperation with PARP1 poly(ADP-ribose) polymerase (zeige PARP1 Proteine) and RPA (zeige RPA1 Proteine).

  5. We conclude that RECQL1 has prognostic and predictive significance in breast cancers.

  6. Our results indicate that the zinc binding motif in the RQC domain of RECQ1 is a key structural element that is essential for the structure-functions of RECQ1.

  7. Knockdown of RECQ1 significantly suppressed lung cancer cell proliferation, migration and invasion.

  8. To better understand the roles of RECQ1, two AL mutants (W227A and F231A) in full-length RECQ1 were characterized biochemically and genetically

  9. RECQL is a new breast cancer susceptibility gene.

  10. RECQL is a DNA helicase in breast cancer [editorial]

RecQ Protein-Like (DNA Helicase Q1-Like) (RECQL) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. Two alternatively spliced transcripts, which encode the same isoform but differ in their 5' and 3' UTRs, have been described.

Genbezeichner und Symbole assoziert mit RECQL

  • RecQ like helicase (RECQL)
  • RecQ helicase-like (recql)
  • ATP-dependent DNA helicase Q1 (CpipJ_CPIJ017275)
  • ATP-dependent DNA helicase Q1 (PAAG_01087)
  • RecQ like helicase (recql)
  • RecQ like helicase L homeolog (recql.L)
  • adenosylhomocysteinase pseudogene (LOC100151819)
  • RecQ protein-like (Recql)
  • RecQ like helicase (Recql)
  • DKFZp469B0921 Protein
  • MGC131022 Protein
  • recq1 Protein
  • RECQL Protein
  • recql1 Protein
  • zgc:110631 Protein

Bezeichner auf Proteinebene für RECQL

ATP-dependent DNA helicase Q1 , RecQ protein-like (DNA helicase Q1-like) , ATP-dependent DNA helicase Q1-like , DNA-dependent ATPase Q1 , recQ protein-like 1 , DNA helicase, RecQ-like type 1

378910 Gallus gallus
533006 Bos taurus
566018 Danio rerio
6051087 Culex quinquefasciatus
9100521 Paracoccidioides sp. 'lutzii' Pb01
100171554 Pongo abelii
465334 Pan troglodytes
486641 Canis lupus familiaris
549070 Xenopus (Silurana) tropicalis
705871 Macaca mulatta
734924 Xenopus laevis
100011463 Monodelphis domestica
100068195 Equus caballus
100151819 Sus scrofa
100226344 Taeniopygia guttata
100470724 Ailuropoda melanoleuca
100586270 Nomascus leucogenys
19691 Mus musculus
5965 Homo sapiens
312824 Rattus norvegicus
Ausgewählte Anbieter für RecQ Protein-Like (DNA Helicase Q1-Like) Proteine (RECQL)
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