Ras Homolog Gene Family, Member T1 Proteine (RHOT1)

Mitochondrial GTPase involved in mitochondrial trafficking. Zusätzlich bieten wir Ihnen RHOT1 Antikörper (60) und RHOT1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RHOT1 55288 Q8IXI2
RHOT1 59040 Q8BG51
Ratte RHOT1 RHOT1 303351  
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Showing 3 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

RHOT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)

Weitere Proteine zu Ras Homolog Gene Family, Member T1 (RHOT1) Interaktionspartnern

Human Ras Homolog Gene Family, Member T1 (RHOT1) Interaktionspartner

  1. Full-length APC (zeige APC Proteine) promotes assembly of the Miro-1/Milton-2 complex.

  2. Miro and Cenp-F (zeige CENPF Proteine) promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

  3. Data indicate that outer mitochondrial membrane protein Miro1 can stabilize phospho-mutant versions of PARK2 (zeige PARK2 Proteine) gene (encoding Parkin (zeige PARK2 Proteine)) on the outer mitochondrial membrane (OMM).

  4. Details of a robust association of DISC1 (zeige DISC1 Proteine) with mitochondrial transport complexes containing TRAK1 (zeige TRAK1 Proteine) and Miro1.

  5. The Miro1-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro1 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.

  6. CXCL12 (zeige CXCL12 Proteine)-dependent cell polarization and migration are reduced in Miro-1-silenced cells

  7. results indicated that the low-expression levels of RhoT1 and Smad4 (zeige SMAD4 Proteine) were significantly associated with LNM and shorter survival. RhoT1 may be considered as a potential novel marker for predicting the outcome in patients with pancreatic cancer

  8. Study shows that both PINK1 (zeige PINK1 Proteine) and Parkin (zeige PARK2 Proteine) halt mitochondrial movement; PINK1 (zeige PINK1 Proteine) phosphorylates Miro (1 and 2) and thereby initiates the rapid degradation of Miro through a Parkin (zeige PARK2 Proteine)- and proteasome-dependent pathway.

  9. Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106 (zeige TRAK1 Proteine), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.

  10. Miro1,2 proteins serve as a [Ca(2 (zeige CA2 Proteine)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.

Mouse (Murine) Ras Homolog Gene Family, Member T1 (RHOT1) Interaktionspartner

  1. Using mouse knockout strategies, we demonstrate that Miro1, as opposed to Miro2 (zeige RHOT2 Proteine), is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 in mature neurons causes a progressive loss

  2. Data establish that Miro1-mediated mitochondrial positioning at the leading edge provides localized energy production that promotes cell migration by supporting membrane protrusion and focal adhesion stability.

  3. This study demonstrated that Miro1 regulates trafficking of mitochondria in the processes of astrocytes, as well as retention of mitochondria at sites that require energy production and Ca2 (zeige CA2 Proteine)+-buffering such as the tripartite synapse

  4. Neuron-specific loss of Miro1 causes depletion of mitochondria from corticospinal tract axons and progressive neurological deficits mirroring human upper motor neuron disease.

  5. Miro1 overexpression leads to increased stem cell repair.

  6. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.

RHOT1 Protein Überblick

Protein Überblick

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Genbezeichner und Symbole assoziert mit RHOT1

  • ras homolog family member T1a (rhot1a)
  • ras homolog family member T2 (rhot2)
  • ras homolog family member T1 (RHOT1)
  • ras homolog family member T1 (rhot1)
  • ras homolog family member T1 L homeolog (rhot1.L)
  • ras homolog family member T1 (Rhot1)
  • ras homolog family member T1 (rhot1b)
  • 2210403N23Rik Protein
  • AA415293 Protein
  • AF244542 Protein
  • AI834919 Protein
  • Arht1 Protein
  • arht2 Protein
  • C430039G08Rik Protein
  • MIRO-1 Protein
  • miro-2 Protein
  • miro1 Protein
  • rasl Protein
  • rhot1 Protein
  • si:dkeyp-97g3.6 Protein
  • wu:fd14e11 Protein
  • wu:fi14a05 Protein
  • zgc:55581 Protein
  • zgc:77063 Protein

Bezeichner auf Proteinebene für RHOT1

MIRO-1-A , mitochondrial Rho GTPase 1-A , ras homolog gene family member T1-A , ras homolog gene family, member T1 , mitochondrial Rho GTPase 2 , ras homolog gene family, member T2 , MIRO-1 , mitochondrial Rho GTPase 1 , ras homolog gene family member T1 , hMiro-1 , mitochondrial Rho (MIRO) GTPase 1 , mitochondrial Rho 1 , rac-GTP binding protein-like protein , rac-GTP-binding protein-like protein , Rhot1a

327143 Danio rerio
448378 Xenopus (Silurana) tropicalis
100022962 Monodelphis domestica
100560389 Anolis carolinensis
100592519 Nomascus leucogenys
100158403 Xenopus laevis
417410 Gallus gallus
55288 Homo sapiens
480613 Canis lupus familiaris
100523466 Sus scrofa
511257 Bos taurus
59040 Mus musculus
303351 Rattus norvegicus
561933 Danio rerio
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