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The protein encoded by RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. Zusätzlich bieten wir Ihnen RD RNA Binding Protein Antikörper (23) und viele weitere Produktgruppen zu diesem Protein an.
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biochemical analysis reveals that the sequence-specific transcription factor, GAF, orchestrates efficient pausing by recruiting NELF to promoters before transcription initiation and by assisting in loading NELF onto Pol II after initiation
The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.
propose that NELF and DSIF (zeige SUPT4H1 Proteine) cause polymerase to pause in the promoter proximal region of hsp70
define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2 (zeige SRRT Proteine)-PHAX (zeige PHAX Proteine), which likely act in respectively earlier and later phases of transcription
A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B (zeige COBRA1 Proteine). NELF-B (zeige COBRA1 Proteine) is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo.
novel actions of BRD4 (zeige BRD4 Proteine) and of NELF-E in GR-controlled gene induction have been uncovered.
Following NELF-E knockdown or tumor necrosis factor alpha stimulation, promoter-proximal RNAP II levels increase up to 3-fold, and there is a dramatic increase in RNAP II levels within the HIV genome.
these results describe the RNA binding behavior of NELF-E and supports a biological role for NELF-E in promoter-proximal pausing of both HIV-1 and cellular genes.
Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC (zeige FAM126A Proteine) within 2 years of surgery.
the transcription elongation of KSHV OriLytL-K7 lytic genes is inhibited by NELF during latency, but can also be promptly reactivated in an RTA (zeige RBM9 Proteine)-independent manner upon external stimuli
data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei
Transient NELF-E knock-down in pituitary increased coincidentally prolactin (zeige PRL Proteine) expression and enhanced transcription of a prolactin (zeige PRL Proteine)-promoter reporter gene.
Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA
The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins\; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.
, negative elongation factor
, negative elongation factor E
, RD RNA binding protein
, RD RNA-binding protein
, RNA-binding protein RD
, major histocompatibility complex gene RD
, negative elongation factor polypeptide E
, nuclear protein