RD RNA Binding Protein Proteine (RDBP)

The protein encoded by RDBP is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. Zusätzlich bieten wir Ihnen RD RNA Binding Protein Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RDBP 7936 P18615
Ratte RDBP RDBP 294258  
RDBP 27632 P19426
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Showing 6 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Human Unkonjugiert   25 μg Anmelden zum Anzeigen 6 Days

RDBP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu RD RNA Binding Protein (RDBP) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) RD RNA Binding Protein (RDBP) Interaktionspartner

  1. biochemical analysis reveals that the sequence-specific transcription factor, GAF, orchestrates efficient pausing by recruiting NELF to promoters before transcription initiation and by assisting in loading NELF onto Pol II after initiation

  2. The finding that both phenotypes of arrested embryos are obtained in embryos that lack maternally provided NELF-A as well as in embryos with reduced levels of maternal NELF-E show that these phenotypes result from the reduced activity of the NELF complex.

  3. propose that NELF and DSIF cause polymerase to pause in the promoter proximal region of hsp70

Human RD RNA Binding Protein (RDBP) Interaktionspartner

  1. define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription

  2. A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E, which is confirmed to bind RNA in vivo.

  3. novel actions of BRD4 and of NELF-E in GR-controlled gene induction have been uncovered.

  4. Following NELF-E knockdown or tumor necrosis factor alpha stimulation, promoter-proximal RNAP II levels increase up to 3-fold, and there is a dramatic increase in RNAP II levels within the HIV genome.

  5. these results describe the RNA binding behavior of NELF-E and supports a biological role for NELF-E in promoter-proximal pausing of both HIV-1 and cellular genes.

  6. Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC within 2 years of surgery.

  7. the transcription elongation of KSHV OriLytL-K7 lytic genes is inhibited by NELF during latency, but can also be promptly reactivated in an RTA-independent manner upon external stimuli

  8. data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei

  9. Transient NELF-E knock-down in pituitary increased coincidentally prolactin expression and enhanced transcription of a prolactin-promoter reporter gene.

  10. Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA

  11. NELF-C and NELF-D are highly related or identical to the protein called TH1, of unknown function. NELF-B and NELF-C or NELF-D are integral subunits that bring NELF-A and NELF-E together. [NELF-B] [NELF-C]

  12. 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity-inducing factor (DSIF)- and NELF-mediated transcriptional pausing has a dual function in regulating immediate-early expression of the human junB gene.

  13. NELF E RRM binds to the single-stranded TAR RNAs with K(d) values in the low-micromolar range.

  14. Negative elongation factor (NELF) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription.

  15. RNA binding to NELF-E RRM induces formation of a helix in the C-terminus. RNA-bound form of NELF-E RRM is very similar to RNA-bound form of U1A RRM, although C-terminus of NELF-E RRM is unstructured in free protein, whereas it is helical in U1A protein.

  16. Our results do not support any major role of the 4 AMD-associated variants in the risk of developing PCV, but favor a predominant association with the RDBP-SKIV2L variants

RD RNA Binding Protein (RDBP) Protein Überblick

Protein Überblick

The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins\; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Genbezeichner und Symbole assoziert mit RD RNA Binding Protein Proteine (RDBP)

  • Negative elongation factor E (Nelf-E)
  • negative elongation factor complex member E (NELFE)
  • negative elongation factor complex member E (Nelfe)
  • negative elongation factor complex member E, Rdbp (Nelfe)
  • anon-66Da Protein
  • cg5994 Protein
  • D6S45 Protein
  • D17H6S45 Protein
  • Dmel\\CG5994 Protein
  • dNelf-E Protein
  • NELF Protein
  • Nelf-e Protein
  • Rd Protein
  • Rdbp Protein
  • RDP Protein

Bezeichner auf Proteinebene für RD RNA Binding Protein Proteine (RDBP)

CG5994-PA , Nelf-E-PA , anonymous-66Da , negative elongation factor , negative elongation factor E , RD RNA binding protein , RD RNA-binding protein , RNA-binding protein RD , major histocompatibility complex gene RD , negative elongation factor polypeptide E , nuclear protein , NELF-E

38982 Drosophila melanogaster
7936 Homo sapiens
294258 Rattus norvegicus
27632 Mus musculus
474854 Canis lupus familiaris
100124384 Sus scrofa
540158 Bos taurus
Ausgewählte Anbieter für RD RNA Binding Protein Proteine (RDBP)
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