anti-RAP2B, Member of RAS Oncogene Family (RAP2B) Antikörper

Human RAP2B, Member of RAS Oncogene Family (RAP2B) Interaktionspartner

1. Coxiella burnetii is a Gram negative bacterium that survives and grows in a large Coxiella replicative vacuole (CRV), which displays lysosomal and autophagic features. This report presents evidence that both, EPAC and its downstream effector Rap2b, were recruited to the CRV. Rap2b wt inhibited the fusion of early Coxiella phagosomes with the fully developed CRV.

2. Low RAP2B expression is associated with Osteosarcoma Progression.

3. Rap2B was overexpressed in cervical cancer tissues and cell lines and knockdown of Rap2B inhibited cervical cancer cell proliferation, migration, and invasion in vitro and suppressed cervical cancer cell growth and metastasis in vivo

4. these results revealed that Rap2B promotes renal cell carcinoma angiogenesis via phosphoinositide 3-kinase/AKT/vascular endothelial growth factor signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma anti-angiogenesis therapy.

5. our results suggested that Rap2b may be a potential therapeutic target for lung cancer.

6. knockdown of Rap2B inhibits the proliferation and invasion in HCC cells. These findings reveal that Rap2B plays an important role in the regulation of HCC progression.

7. miR-194 is inversely correlated with RAP2B.

8. Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK, suggesting that FAK-dependent pathway might be responsible for the effect of Rap2B on PCa cells migration and invasion.

9. Expression and DNA methylation status of the Rap2B gene in human bronchial epithelial cells treated by cigarette smoke condensate

10. Our collective findings provide preliminary evidence that miR-342-3p acts as a tumor suppressor in small cell lung cancer through repression of RAP2B.

11. Rap2B itself is not necessary for p53-dependent cell cycle arrest.

12. Data indicate that rap GTP-binding protein Rap2B expression is significantly increased in suprarenal epithelioma and Rap2B can promote the cell migration and invasion abilities, suggesting a target for the treatment of suprarenal epithelioma.

13. Rap2b mediates the pro-survival function of p53 upon DNA damage.

14. This protein has been found differentially expressed in thalami from patients with schizophrenia.

15. Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B

16. the small GTPase Rap2B is involved in platelet activation

17. A cDNA library consisting of 220 upregulated genes in tumour tissue was established and named as LSCC. Differential expression was confirmed in five of these genes, including IGFBP5, SQLE, RAP2B, CLDN1, and TBL1XR1.

18. These results demonstrate that Rap2b, but not the more abundant Rap1b, is associated to lipid rafts in human platelets.

Mouse (Murine) RAP2B, Member of RAS Oncogene Family (RAP2B) Interaktionspartner

1. Taken together, these findings shed light on Rap2B as a therapeutic target for breast cancer.

2. the putative Rap2 binding site of the RPIPx RUN domain interacts with the extended segment in a segment-swapping manner