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Seems to have a role in retrograde membrane traffic at the level of the Golgi complex.
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Conformational changes in human neuronal Rab6B between its inactive GDP and active GTP (zeige AK3 Proteine)-like state are observed mainly in the switch I and switch II regions, confirming their role as a molecular switch.
The brain-specific (zeige CALY Proteine) Rab6B via Bicaudal-D1 is linked to the dynein/dynactin (zeige DCTN1 Proteine) complex, suggesting a regulatory role for Rab6B in the retrograde transport of cargo in neuronal cells.
DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi.
Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity).
RAB6B, member RAS oncogene family
, ras-related protein Rab-6B
, small GTP-binding protein
, small GTPase RAB6B