RAB35, Member RAS Oncogene Family Proteine (RAB35)

In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Zusätzlich bieten wir Ihnen RAB35 Antikörper (87) und RAB35 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAB35 11021 Q15286
RAB35 77407 Q6PHN9
RAB35 288700 Q5U316
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

RAB35 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartnern

Human RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartner

  1. The authors propose that Rab35-GTP (zeige AK3 Proteine) is a critical regulator of autophagy through recruiting autophagy receptor NDP52 (zeige CALCOCO2 Proteine).

  2. The results provide evidence that MICAL1 (zeige MICAL1 Proteine) plays an essential role in the activation of ROS (zeige ROS1 Proteine)/Akt (zeige AKT1 Proteine) signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 (zeige MICAL1 Proteine) in regulating breast cancer cell invasion.

  3. The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review].

  4. Data suggest that Rab35, interacting with TBC1D10A (zeige TBC1D10A Proteine), functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (zeige CA2 Proteine)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 (zeige ACAP2 Proteine) and Arf6 (zeige ARF6 Proteine). (Rab35 = rab (zeige HRB Proteine) GTP-binding protein 53 (zeige IGFBP3 Proteine); TBC1D10A (zeige TBC1D10A Proteine) = TBC1 domain family member 10A (zeige TBC1D10A Proteine); ACAP2 (zeige ACAP2 Proteine) = centaurin beta2; Arf6 (zeige ARF6 Proteine) = ADP-ribosylation factor 6 (zeige ARF6 Proteine))

  5. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2 (zeige GIT2 Proteine), prolonged stimulation leads to a decrease of their interaction through activating Rab35.

  6. Here the authors report that EspG interacts specifically with the small GTPases ARF6 (zeige ARF6 Proteine) and Rab35 during infection.

  7. Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.

  8. Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.

  9. the activation-inactivation cycles of Rab35 and ARF6 (zeige ARF6 Proteine) are required for the uptake of zymosan and that ACAP2 (zeige ACAP2 Proteine) is an important component that links Rab35/ARF6 (zeige ARF6 Proteine) signaling during phagocytosis of zymosan.

  10. Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K/AKT (zeige AKT1 Proteine) signaling, suppress apoptosis, and transform cells in a PI3K-dependent manner.

Mouse (Murine) RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartner

  1. This study demonstrated that Rab35 regulates Cdc42 (zeige CDC42 Proteine) activity in neurons.

  2. The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.

  3. Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.

  4. Rab35 regulates phagosome formation through recruitment of ACAP2 (zeige ACAP2 Proteine) in macrophages during FcgammaR-mediated phagocytosis.

  5. The minimal functional Rab35-binding site of RUSC2 was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP (zeige AK3 Proteine)-Rab35-specific trapper.

  6. Rab35 colocalizes with actin filaments and with Cdc42 (zeige CDC42 Proteine), Rac1 and RhoA (zeige RHOA Proteine), and that Rab35 can activate Cdc42 (zeige CDC42 Proteine) both in vivo and in vitro

  7. study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35

RAB35 Protein Überblick

Protein Überblick

In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.

Genbezeichner und Symbole assoziert mit RAB35

  • RAB35, member RAS oncogene family S homeolog (rab35.S)
  • RAB35, member RAS oncogene family (rab35)
  • RAB35, member RAS oncogene family b (rab35b)
  • RAB35, member RAS oncogene family (RAB35)
  • RAB35, member RAS oncogene family (Rab35)
  • 9530019H02Rik Protein
  • AU040256 Protein
  • dZ146N9.2 Protein
  • H-ray Protein
  • MGC69101 Protein
  • MGC76044 Protein
  • RAB1C Protein
  • RAY Protein
  • si:busm1-146n9.2 Protein
  • zgc:100812 Protein

Bezeichner auf Proteinebene für RAB35

RAB35, member RAS oncogene family , ras-related protein Rab-35 , GTP-binding protein RAY , ras-related protein rab-1c (GTP-binding protein ray)

379665 Xenopus laevis
394615 Xenopus (Silurana) tropicalis
445154 Danio rerio
698400 Macaca mulatta
100196061 Salmo salar
100230414 Taeniopygia guttata
100528153 Ictalurus punctatus
11021 Homo sapiens
77407 Mus musculus
288700 Rattus norvegicus
416983 Gallus gallus
611477 Canis lupus familiaris
614521 Bos taurus
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