RAB35, Member RAS Oncogene Family Proteine (RAB35)

In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. Zusätzlich bieten wir Ihnen RAB35 Antikörper (87) und RAB35 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAB35 11021 Q15286
RAB35 77407 Q6PHN9
RAB35 288700 Q5U316
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 15 bis 19 Tage
$492.31
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,489.67
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RAB35 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartnern

Human RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartner

  1. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

  2. The authors propose that Rab35-GTP is a critical regulator of autophagy through recruiting autophagy receptor NDP52.

  3. The results provide evidence that MICAL1 plays an essential role in the activation of ROS/Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion.

  4. The involvement of Rab35 in diverse and apparently unrelated cellular functions can be explained by the central role of this GTPase in regulating phosphoinositides and F-actin, both on endosomes and at the plasma membrane[review].

  5. Data suggest that Rab35, interacting with TBC1D10A, functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6. (Rab35 = rab GTP-binding protein 53; TBC1D10A = TBC1 domain family member 10A; ACAP2 = centaurin beta2; Arf6 = ADP-ribosylation factor 6)

  6. Short-term EGF stimulation if of lung tumor cells can increase the interaction between RUSC2 and GIT2, prolonged stimulation leads to a decrease of their interaction through activating Rab35.

  7. Here the authors report that EspG interacts specifically with the small GTPases ARF6 and Rab35 during infection.

  8. Authors propose that the precise spatial and temporal activation of Rab35 acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.

  9. Rab35 serves as a clathrin-mediated endocytosis detector. Loss of Rab35 input leads to elevated Arf6-GTP and shifts the sorting of clathrin-independent endocytosis cargo proteins to lysosomes.

  10. the activation-inactivation cycles of Rab35 and ARF6 are required for the uptake of zymosan and that ACAP2 is an important component that links Rab35/ARF6 signaling during phagocytosis of zymosan.

  11. Two somatic RAB35 mutations found in human tumors generate alleles that constitutively activate PI3K/AKT signaling, suppress apoptosis, and transform cells in a PI3K-dependent manner.

  12. mutual regulation with arf6 of cell adhesion and migration

  13. Rab35 acts as a downstream target of Dvl2 and mediates cell migration.

  14. Activated ARF6 reduces Rab35 loading into the endocytic pathway.

  15. whereas connecdenn 1 and 2 activate Rab35 for endosomal trafficking, connecdenn 3 uniquely activates Rab35 for its role in actin regulation

  16. analysis of DENND1B-S complexed with its substrate Rab35

  17. the phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) 5-phosphatase OCRL, which is mutated in Lowe syndrome patients, is an effector of the Rab35 GTPase in cytokinesis abscission

  18. A Small Ras-like GTPase protein Ray was indicated to modulate p53 transcriptional activity of PRPK.

  19. localized to the plasma membrane and endocytic compartments and controls a fast endocytic recycling pathway; plays an essential role during the terminal steps of cytokinesis

  20. EPI64C and Rab35 regulate a recycling pathway in T cells and contribute to immunological synapse formation, most likely by participating in TCR transport to the immunological synapse

Mouse (Murine) RAB35, Member RAS Oncogene Family (RAB35) Interaktionspartner

  1. A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

  2. This study demonstrated that Rab35 regulates Cdc42 activity in neurons.

  3. The Rab35 plays an important role in spindle organization and morphology maintenance, and thus meiotic nuclear maturation.

  4. Rab35 regulates myoblast fusion, a major cellular process under the control of cadherin-dependent signaling.

  5. Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.

  6. The minimal functional Rab35-binding site of RUSC2 was identified at the amino acid residues 982-1199 and succeeded in developing a novel GTP-Rab35-specific trapper.

  7. Rab35 colocalizes with actin filaments and with Cdc42, Rac1 and RhoA, and that Rab35 can activate Cdc42 both in vivo and in vitro

  8. study found that Rab35 regulates the assembly of actin filaments in filopodia formation; effect was mediated by the actin-bundling protein fascin, which directly associated with active Rab35

RAB35 Protein Überblick

Protein Überblick

In the process of endocytosis, essential rate-limiting regulator of a fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge.

Genbezeichner und Symbole assoziert mit RAB35

  • RAB35, member RAS oncogene family S homeolog (rab35.S)
  • RAB35, member RAS oncogene family (rab35)
  • RAB35, member RAS oncogene family b (rab35b)
  • RAB35, member RAS oncogene family (RAB35)
  • RAB35, member RAS oncogene family (Rab35)
  • 9530019H02Rik Protein
  • AU040256 Protein
  • dZ146N9.2 Protein
  • H-ray Protein
  • MGC69101 Protein
  • MGC76044 Protein
  • RAB1C Protein
  • RAY Protein
  • si:busm1-146n9.2 Protein
  • zgc:100812 Protein

Bezeichner auf Proteinebene für RAB35

RAB35, member RAS oncogene family , ras-related protein Rab-35 , GTP-binding protein RAY , ras-related protein rab-1c (GTP-binding protein ray)

GENE ID SPEZIES
379665 Xenopus laevis
394615 Xenopus (Silurana) tropicalis
445154 Danio rerio
698400 Macaca mulatta
100196061 Salmo salar
100230414 Taeniopygia guttata
100528153 Ictalurus punctatus
11021 Homo sapiens
77407 Mus musculus
288700 Rattus norvegicus
416983 Gallus gallus
611477 Canis lupus familiaris
614521 Bos taurus
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