RAB27B, Member RAS Oncogene Family Proteine (RAB27B)

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010].. Zusätzlich bieten wir Ihnen RAB27B Antikörper (80) und RAB27B Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAB27B 5874 O00194
RAB27B 80718 Q99P58
RAB27B 84590 Q99P74
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Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,539.17
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,539.17
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Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days
$4,125.00
Details

RAB27B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartnern

Rabbit RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. Rab27b enrichment occurs early in secretory vesicle formation.

  2. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

  3. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.

Human RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. Findings indicate that rab (zeige HRB Proteine) GTP-binding (zeige RND2 Proteine) proteins Rab27A (zeige RAB27A Proteine) and Rab27B play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance.

  2. RAB27A (zeige RAB27A Proteine), RAB27B and VPS36 (zeige VPS36 Proteine) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A (zeige RAB27A Proteine), RAB27B and VPS36 (zeige VPS36 Proteine), with RAB27A (zeige RAB27A Proteine) and RAB27B being dependent on VPS36 (zeige VPS36 Proteine).

  3. decreased expression of Rab27A (zeige RAB27A Proteine) and Rab27B, especially Rab27A (zeige RAB27A Proteine), closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

  4. Data indicate that a significant correlation between rab (zeige HRB Proteine) GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53 (zeige TP53 Proteine)) expression was observed.

  5. MiR (zeige MLXIP Proteine)-193a-3p and miR (zeige MLXIP Proteine)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR (zeige SRR Proteine) genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma

  6. These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D (zeige RAB3D Proteine).

  7. Experimental data are reviewed with a focus on the secretory Rab27 (zeige RAB27A Proteine) family of small GTPases and their implications in cancer progression.

  8. Decreased invasion partly resulted from reduced expression and activation of MMP-9 (zeige MMP9 Proteine) after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo.

  9. Data indicate that the secretion of microRNA miR (zeige MLXIP Proteine)-143, depends on rab (zeige HRB Proteine) GTP-binding (zeige RND2 Proteine) proteins Rab7a (zeige RAB7A Proteine) and Rab27b.

  10. Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.

Mouse (Murine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.

  2. this study shows that Rab27a (zeige RAB27A Proteine) and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation

  3. PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.

  4. Loss of Rab3D (zeige RAB3D Proteine) from secretory vesicles, leading to disproportionate Rab27 (zeige RAB27A Proteine)-to-Rab3D (zeige RAB3D Proteine) activity, may contribute to the enhanced release of cathepsin S (zeige CTSS Proteine) in tears of patients with Sjogren's syndrome.

  5. Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b (zeige RAB27A Proteine) double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 (zeige CXCL2 Proteine) and LTB4 (zeige PTGR1 Proteine).

  6. EPI64B (zeige TBC1D10B Proteine) can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.

  7. Expression of Rab27b DN constructs resulted in dispersed collagen vesicles which may represent failed secretory vesicles sequestered in the cytosol.

  8. Data suggest that Rab27a (zeige RAB27A Proteine) and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (zeige RAB27A Proteine)/Mlph (zeige MLPH Proteine)/MyoVa (zeige MYO5A Proteine) regulating cortical actin stability upstream of Rab27a/b (zeige RAB27A Proteine)/Munc13-4 (zeige UNC13D Proteine)-dependent granule exocytosis.

  9. Data indicate that inhibition of Rab27a (zeige RAB27A Proteine), but not Rab27b, affects exosome secretion.

  10. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

Cow (Bovine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

RAB27B Protein Überblick

Protein Überblick

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997

Genbezeichner und Symbole assoziert mit RAB27B

  • RAB27B, member RAS oncogene family L homeolog (rab27b.L)
  • RAB27B, member RAS oncogene family (rab27b)
  • RAB27B, member RAS oncogene family (RAB27B)
  • RAB27B, member RAS oncogene family (Rab27b)
  • 2310021G14Rik Protein
  • B130064M09Rik Protein
  • C25KG Protein
  • MGC79588 Protein
  • MGC80016 Protein
  • RAB27B Protein

Bezeichner auf Proteinebene für RAB27B

RAB27B, member RAS oncogene family , ras-related protein Rab-27B

GENE ID SPEZIES
414551 Xenopus laevis
448182 Xenopus (Silurana) tropicalis
468542 Pan troglodytes
694445 Macaca mulatta
100343056 Oryctolagus cuniculus
5874 Homo sapiens
80718 Mus musculus
84590 Rattus norvegicus
282858 Bos taurus
483974 Canis lupus familiaris
101096852 Felis catus
101120036 Ovis aries
100732593 Cavia porcellus
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