RAB27B, Member RAS Oncogene Family Proteine (RAB27B)

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010].. Zusätzlich bieten wir Ihnen RAB27B Antikörper (81) und RAB27B Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RAB27B 5874 O00194
RAB27B 80718 Q99P58
RAB27B 84590 Q99P74
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top RAB27B Proteine auf antikoerper-online.de

Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
Details
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,539.17
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,539.17
Details
Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days
$4,125.00
Details

RAB27B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartnern

Rabbit RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. Rab27b enrichment occurs early in secretory vesicle formation.

  2. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

  3. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.

Human RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. Findings indicate that rab GTP-binding proteins Rab27A and Rab27B play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance.

  2. RAB27A, RAB27B and VPS36 are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A, RAB27B and VPS36, with RAB27A and RAB27B being dependent on VPS36.

  3. decreased expression of Rab27A and Rab27B, especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

  4. Data indicate that a significant correlation between rab GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53) expression was observed.

  5. MiR-193a-3p and miR-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma

  6. These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D.

  7. Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.

  8. Decreased invasion partly resulted from reduced expression and activation of MMP-9 after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo.

  9. Data indicate that the secretion of microRNA miR-143, depends on rab GTP-binding proteins Rab7a and Rab27b.

  10. Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.

  11. Silencing of the exocytotic RAB family members RAB27A or RAB27B halted miR23b and miR921 secretion and reduced cellular invasion.

  12. inhibiting V-ATPase activity by interfering agents and drugs might be an effective strategy for blocking Rab27B-dependent proinvasive secretory vesicle trafficking in ERalpha-positive breast cancer patients

  13. findings suggest that overexpression of Rab27B in BC coincides with lymph node metastasis and acquisition of a poor prognostic phenotype

  14. These results suggest that Rab27b negatively regulates the cell surface expression of c-kit via secretion of SCF and that ligation of SCF leads to the endolysosomal degradation system of c-kit.

  15. in human breast cancer specimens, the presence of Rab27B protein proved to be associated with a low degree of differentiation and the presence of lymph node metastasis in ER-positive breast cancer

  16. were unable to find any mutation in the coding sequence of RAB27B in five patients suffering from different types of platelet delta-storage pool deficiency

  17. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.

  18. Rab27B regulates invasive growth and metastasis in ER-positive breast cancer cell lines, and increased expression is associated with poor prognosis in humans.

  19. Chromosomal mapping and gene structure of the RAB27B gene.

  20. Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types.

Mouse (Murine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.

  2. this study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation

  3. PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.

  4. Loss of Rab3D from secretory vesicles, leading to disproportionate Rab27-to-Rab3D activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.

  5. Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 and LTB4.

  6. EPI64B can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.

  7. Expression of Rab27b DN constructs resulted in dispersed collagen vesicles which may represent failed secretory vesicles sequestered in the cytosol.

  8. Data suggest that Rab27a and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a/Mlph/MyoVa regulating cortical actin stability upstream of Rab27a/b/Munc13-4-dependent granule exocytosis.

  9. Data indicate that inhibition of Rab27a, but not Rab27b, affects exosome secretion.

  10. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

  11. Stimulation-dependent lysosomal RANKL release is mediated by Rab27a/b and their effector molecules, and this mechanism may be important for osteoclast activation in vivo.

  12. Morphological changes observed at the ultrastructural level in Rab27b-deficient lung samples result from secretory defects in alveolar epithelial type II and Clara cells that, over time, lead to atrophy of the epithelium.

  13. Both Rab27a and Rab27b deficiencies impaired azurophilic granule exocytosis. Rab27a(ash/ash) neutrophils showed upregulation of Rab27b expression which did not compensate for the secretory defects observed in Rab27a-deficient cells.

  14. Chromosomal mapping and gene structure of the RAB27B gene.

  15. Rab27b is involved in pituitary hormone secretion

  16. Rab27b may regulate the outward movement of melanosomes and the formation or maintenance of dendritic extensions in melanocytes.

  17. Rab27b is functionally redundant with Rab27a and the pathogenesis of Griscelli syndrome is determined by the relative expression of Rab27a and Rab27b in specialized cell types.

  18. Rab27b in particular may coordinate proplatelet formation with granule transport, possibly by recruiting specific effector pathways

  19. plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells of bladder epithelium

  20. The acroplaxome provides a focal point for myosin-Va/ Rab27a/b-driven proacrosomal vesicles to accumulate, coalesce, and form an acrosome in wild-type spermatids and a pseudoacrosome in Hrb mutant spermatids.

Cow (Bovine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

  1. plays a role in regulating the delivery of fusiform vesicles to the apical plasma membrane of umbrella cells of bladder epithelium

RAB27B Protein Überblick

Protein Überblick

Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997

Genbezeichner und Symbole assoziert mit RAB27B

  • RAB27B, member RAS oncogene family L homeolog (rab27b.L)
  • RAB27B, member RAS oncogene family (rab27b)
  • RAB27B, member RAS oncogene family (RAB27B)
  • RAB27B, member RAS oncogene family (Rab27b)
  • 2310021G14Rik Protein
  • B130064M09Rik Protein
  • C25KG Protein
  • MGC79588 Protein
  • MGC80016 Protein
  • RAB27B Protein

Bezeichner auf Proteinebene für RAB27B

RAB27B, member RAS oncogene family , ras-related protein Rab-27B

GENE ID SPEZIES
414551 Xenopus laevis
448182 Xenopus (Silurana) tropicalis
468542 Pan troglodytes
694445 Macaca mulatta
100343056 Oryctolagus cuniculus
5874 Homo sapiens
80718 Mus musculus
84590 Rattus norvegicus
282858 Bos taurus
483974 Canis lupus familiaris
101096852 Felis catus
101120036 Ovis aries
100732593 Cavia porcellus
Ausgewählte Anbieter für RAB27B Proteine (RAB27B)
Haben Sie etwas anderes gesucht?