RAB27B, Member RAS Oncogene Family Proteine (RAB27B)

Rabbit RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

1. Rab27b enrichment occurs early in secretory vesicle formation.

2. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

3. Rab27b is associated with tubulovesicle membranes in the parietal cell and Rab27b may play a role in stimulation-associated membrane recruitment and gastric acid secretion.

Human RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

1. Findings indicate that rab (zeige HRB Proteine) GTP-binding (zeige RND2 Proteine) proteins Rab27A (zeige RAB27A Proteine) and Rab27B play significant roles in cell invasion, proliferation, and apoptosis, as well as in chemotherapy resistance.

2. RAB27A (zeige RAB27A Proteine), RAB27B and VPS36 (zeige VPS36 Proteine) are frequently underexpressed in advanced prostate cancer and are inversely correlated with prostate cancer outcome. There seems to be a close relationship in the expression of RAB27A (zeige RAB27A Proteine), RAB27B and VPS36 (zeige VPS36 Proteine), with RAB27A (zeige RAB27A Proteine) and RAB27B being dependent on VPS36 (zeige VPS36 Proteine).

3. decreased expression of Rab27A (zeige RAB27A Proteine) and Rab27B, especially Rab27A (zeige RAB27A Proteine), closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

4. Data indicate that a significant correlation between rab (zeige HRB Proteine) GTP-binding protein (RAB27B) and p53 tumor suppressor protein (p53 (zeige TP53 Proteine)) expression was observed.

5. MiR (zeige MLXIP Proteine)-193a-3p and miR (zeige MLXIP Proteine)-193a-5p play important roles in osteosarcoma metastasis through down-regulation of the Rab27B and SRR (zeige SRR Proteine) genes and therefore may serve as useful biomarkers for the diagnosis of osteosarcoma

6. These data indicate that Rab27B is involved at a different steps of zymogen granule maturation and secretion, which is distinct from that of Rab3D (zeige RAB3D Proteine).

7. Experimental data are reviewed with a focus on the secretory Rab27 (zeige RAB27A Proteine) family of small GTPases and their implications in cancer progression.

8. Decreased invasion partly resulted from reduced expression and activation of MMP-9 (zeige MMP9 Proteine) after Rab27b knockdown. Downregulation of Rab27b also suppressed tumor growth in vivo.

9. Data indicate that the secretion of microRNA miR (zeige MLXIP Proteine)-143, depends on rab (zeige HRB Proteine) GTP-binding (zeige RND2 Proteine) proteins Rab7a (zeige RAB7A Proteine) and Rab27b.

10. Rab27B nuclear expression is correlated with several clinicopathological features of GIST patients, and it may serve as an unfavorable prognostic marker.

Mouse (Murine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner

1. While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.

2. this study shows that Rab27a (zeige RAB27A Proteine) and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation

3. PI3K-dependent formation of a kinesin-1/Slp3/Rab27b complex is critical for the microtubule-dependent movement of secretory granules required for mast cell degranulation.

4. Loss of Rab3D (zeige RAB3D Proteine) from secretory vesicles, leading to disproportionate Rab27 (zeige RAB27A Proteine)-to-Rab3D (zeige RAB3D Proteine) activity, may contribute to the enhanced release of cathepsin S (zeige CTSS Proteine) in tears of patients with Sjogren's syndrome.

5. Rab27b is expressed in bone marrow derived neutrophils and Rab27b knockout (Rab27b KO) along with Rab27a/b (zeige RAB27A Proteine) double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 (zeige CXCL2 Proteine) and LTB4 (zeige PTGR1 Proteine).

6. EPI64B (zeige TBC1D10B Proteine) can serve as a potential physiological GAP for Rab27B and thereby participate in the regulation of exocytosis in pancreatic acinar cells.

7. Expression of Rab27b DN constructs resulted in dispersed collagen vesicles which may represent failed secretory vesicles sequestered in the cytosol.

8. Data suggest that Rab27a (zeige RAB27A Proteine) and Rab27b regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a (zeige RAB27A Proteine)/Mlph (zeige MLPH Proteine)/MyoVa (zeige MYO5A Proteine) regulating cortical actin stability upstream of Rab27a/b (zeige RAB27A Proteine)/Munc13-4 (zeige UNC13D Proteine)-dependent granule exocytosis.

9. Data indicate that inhibition of Rab27a (zeige RAB27A Proteine), but not Rab27b, affects exosome secretion.

10. Rab27b participates in aspects of lacrimal gland acinar cell secretory vesicle formation and release.

Cow (Bovine) RAB27B, Member RAS Oncogene Family (RAB27B) Interaktionspartner