Pyridoxamine 5'-Phosphate Oxidase Proteine (PNPO)

The enzyme encoded by PNPO catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Zusätzlich bieten wir Ihnen PNPO Antikörper (85) und PNPO Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PNPO 55163 Q9NVS9
PNPO 64533 O88794
PNPO 103711 Q91XF0
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human PNPO Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Escherichia coli (E. coli) Maus Unkonjugiert SDS-PAGE analysis of Mouse PNPO Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$668.03
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,674.83
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,674.83
Details
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$3,655.38
Details

PNPO Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,
,

Weitere Proteine zu Pyridoxamine 5'-Phosphate Oxidase (PNPO) Interaktionspartnern

Human Pyridoxamine 5'-Phosphate Oxidase (PNPO) Interaktionspartner

  1. TGF-beta1-mediated PNPO expression was at least in part through the upregulation of miR-143-3p in epithelial ovarian cancer.

  2. data support a pathogenic role of the c.347G>A (p.Arg116Gln) mutation in PNPO deficiency; the later onset of symptoms and the milder epilepsy phenotype of these expand the disease phenotype

  3. Exome sequencing revealed that the patient was compound heterozygous for pathogenic mutations [c.546+1G>A (IVS5+1 G>A) and c.620delG (p.G207VfsX215)] in the PNPO gene.

  4. One sequence variant, R116Q, a single nucleotide polymorphism that has been reported in the general population, was found to have an effect on PNPO activity.

  5. Challenge to the paradigm of exclusive PLP responsiveness in patients with pyridoxal 5'-phosphate oxidase deficiency and underlines the importance of consecutive testing of pyridoxine and PLP in neonates with antiepileptic drug-resistant seizures.

  6. Generalized epilepsies implicates susceptibility genes: CHRM3 at 1q43, VRK2 at 2p16.1, ZEB2 at 2q22.3, SCN1A at 2q24.3 and PNPO at 17q21.32.

  7. provide evidence that a single arginine residue of the C terminus of pyridoxal 5'-phosphate synthase is responsible for coordinating co-operativity in this elaborate protein machinery

  8. Results describe a combined computer and biochemical approach to characterize human pyridoxine 5'-phosphate oxidase (PNPO).

  9. several mutations appear to cause epilepsy

  10. We examined 8 single nucleotide polymorphisms (SNPs) in PNPO and its 5'-flanking regions in 359 schizophrenia patients and 582 control subjects.

  11. Sequencing of the PNPO gene revealed a novel homozygous nonsense mutationt in exon 3 in the neonatal and infantile seizure.

  12. PNP oxidase R229W mutation identified in patients with neonatal epileptic encephalopathy sgnificantly affect the catalytic efficiency of the enzyme.

PNPO Protein Überblick

Protein Überblick

The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy.

Genbezeichner und Symbole assoziert mit PNPO

  • pyridoxamine 5'-phosphate oxidase (pnpo)
  • pyridoxine 5'-phosphate oxidase (pdxH)
  • pyridoxamine 5'-phosphate oxidase (Mrub_2888)
  • pyridoxamine 5'-phosphate oxidase (Arnit_1624)
  • pyridoxamine 5'-phosphate oxidase (Ndas_4168)
  • pyridoxamine 5'-phosphate oxidase (Mesil_2817)
  • Pyridoxamine 5'-phosphate oxidase (Isop_0296)
  • Pyridoxamine 5'-phosphate oxidase (Despr_1960)
  • Pyridoxamine 5'-phosphate oxidase (Pedsa_1348)
  • pyridoxamine 5'-phosphate oxidase (Mesop_5639)
  • pyridoxamine 5'-phosphate oxidase (PNPO)
  • pyridoxamine 5'-phosphate oxidase (Pnpo)
  • pyridoxine 5'-phosphate oxidase (Pnpo)
  • AI415282 Protein
  • ECK1634 Protein
  • im:7138360 Protein
  • JW1630 Protein
  • PDXPO Protein

Bezeichner auf Proteinebene für PNPO

pyridoxine-5'-phosphate oxidase , pyridoxamine 5'-phosphate oxidase , Pyridoxamine 5'-phosphate oxidase , pyridoxal 5'-phosphate synthase , pyridoxamine-phosphate oxidase , pyridoxine 5'-phosphate oxidase , pyridoxine 5-phosphate oxidase

GENE ID SPEZIES
402868 Danio rerio
946806 Escherichia coli str. K-12 substr. MG1655
8881004 Meiothermus ruber DSM 1279
9171784 Arcobacter nitrofigilis DSM 7299
9248042 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9252339 Meiothermus silvanus DSM 9946
10154400 Isosphaera pallida ATCC 43644
10174688 Desulfobulbus propionicus DSM 2032
10230903 Pedobacter saltans DSM 12145
10829504 Mesorhizobium opportunistum WSM2075
55163 Homo sapiens
480540 Canis lupus familiaris
512573 Bos taurus
64533 Rattus norvegicus
103711 Mus musculus
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