Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteine (P2RX3)

The product of P2RX3 belongs to the family of purinoceptors for ATP. Zusätzlich bieten wir Ihnen Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Antikörper (78) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte P2RX3 P2RX3 81739 P49654
P2RX3 5024 P56373
P2RX3 228139 Q3UR32
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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P2RX3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,

Weitere Proteine zu Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartnern

Human Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartner

  1. Druggable negative allosteric site of P2X3 receptors.

  2. conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R

  3. P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain.

  4. P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.

  5. X-ray crystal structures of the human P2X3 receptor in apo (zeige C9orf3 Proteine)/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states

  6. there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor (zeige P2RX7 Proteine) in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.

  7. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (zeige P2RX1 Proteine) hP2X2/3 channel.

  8. Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) therapy.

  9. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (zeige P2RX2 Proteine) and P2X3 subunits

  10. Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.

Mouse (Murine) Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartner

  1. This study demonstrated that the P2X3-immunoreactive nerve endings in the rat tracheal mucosa have unique morphological characteristics, and these endings may be rapidly adapting receptors and/or irritant receptors that are activated by mucosal irritant stimuli.

  2. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A (zeige NPR1 Proteine) pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  3. P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (zeige BNP Proteine) and facilitatory calcitonin gene-related peptide (zeige CALCA Proteine) that both operate via complex intracellular signaling.

  4. mouse trigeminal neurons endogenous BNP acts on NPR-A (zeige NPR1 Proteine) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A (zeige NPR1 Proteine)/PKG (zeige PRKG1 Proteine) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments

  5. This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (zeige P2RX2 Proteine)/P2X3 knockout mice.

  6. a slow modulatory action by BNP on TRPV1 (zeige TRPV1 Proteine) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli

  7. P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin

  8. genetic manipulation of TRPV1 (zeige TRPV1 Proteine) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.

  9. up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (zeige CALCA Proteine) and BDNF (zeige BDNF Proteine) levels

  10. Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]

Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Protein Überblick

Protein Überblick

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

Genbezeichner und Symbole assoziert mit P2RX3

  • purinergic receptor P2X 3 (P2RX3)
  • purinergic receptor P2X 3 (P2rx3)
  • purinergic receptor P2X, ligand-gated ion channel, 3 (P2rx3)
  • 4930513E20Rik Protein
  • P2RX3 Protein
  • P2X3 Protein

Bezeichner auf Proteinebene für P2RX3

purinergic receptor P2X, ligand-gated ion channel, 3 , P2X3 purinoceptor , purinergic receptor P2X3 , ATP receptor , P2X purinoceptor 3 , P2X3 , P2X receptor, subunit 3 , purinoceptor P2X3

GENE ID SPEZIES
428856 Gallus gallus
448782 Canis lupus familiaris
530468 Bos taurus
742961 Pan troglodytes
81739 Rattus norvegicus
5024 Homo sapiens
228139 Mus musculus
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