Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteine (P2RX3)

The product of P2RX3 belongs to the family of purinoceptors for ATP. Zusätzlich bieten wir Ihnen Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Antikörper (82) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
P2RX3 5024 P56373
Ratte P2RX3 P2RX3 81739 P49654
P2RX3 228139 Q3UR32
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$814.00
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P2RX3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine)
,

Weitere Proteine zu Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartnern

Human Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartner

  1. Druggable negative allosteric site of P2X3 receptors.

  2. conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R

  3. P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain.

  4. P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.

  5. X-ray crystal structures of the human P2X3 receptor in apo/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states

  6. there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.

  7. Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor hP2X2/3 channel.

  8. Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC) therapy.

  9. Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 and P2X3 subunits

  10. Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.

  11. The results from this study demonstrate that there is a significant difference in the expression of the purinergic P2X2, P2X3 and P2X7 receptors in the different histological layers of the human urinary bladder.

  12. sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns

  13. esophagitis increases mRNA expressions of P2X3 and P2X7 receptors accompanied by up-regulation of TRPV1 and neurotrophic factors (NGF and GDNF).

  14. Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening

  15. TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve

  16. Data indicate that Markov models are suitable to simulate agonist antagonist interactions at fast desensitizing receptors such as the P2X3R.

  17. ATP-gated P2X3 channels in enterochromaffin cells are downregulated in ulcerative colitis.

  18. Data indicate that MgATP2- activates P2X1 and P2X3, but not P2X2 and P2X4 receptors.

  19. An early and broad expression of P2X3 receptors was found in prenatal dorsal root ganglion neurons.

  20. HEK 293 cells are not permissive for stable P2X3 expression afer a significant time-dependent cell loss; often used in a recmbinant expression system, HEK cells represent a limiting permissive environment for P2X3 receptors.

Mouse (Murine) Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartner

  1. This study demonstrated that the P2X3-immunoreactive nerve endings in the rat tracheal mucosa have unique morphological characteristics, and these endings may be rapidly adapting receptors and/or irritant receptors that are activated by mucosal irritant stimuli.

  2. Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.

  3. P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide and facilitatory calcitonin gene-related peptide that both operate via complex intracellular signaling.

  4. mouse trigeminal neurons endogenous BNP acts on NPR-A receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments

  5. may be involved in skeletal pain due to high bone turnover

  6. This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.

  7. a slow modulatory action by BNP on TRPV1 and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli

  8. P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin

  9. genetic manipulation of TRPV1 and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.

  10. up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP and BDNF levels

  11. Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]

  12. interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice.

  13. An interaction between P2X3 and membrane-associated ERalpha in primary sensory neurones that may represent a novel mechanism to explain sex differences observed in the clinical presentation of visceral nociceptive syndromes.

  14. Transcripts for P2X3 were present in nearly all colon neurons examined. About half of the cells only containing P2X3 transcripts, and zymosan did not change this. The fast current triggered by ATP and alpha,beta-meATP is dependent on P2X3 receptors.

  15. CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin.

  16. chronic esophagitis results in upregulation of P2X(3) and its co-localization with TRPV1 receptor in vagal and spinal afferents.

  17. Data suggest that double P2X2/P2X3 purinergic receptor knockout mice are unable to respond to NaCl or the artificial sweetener SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances.

  18. In brief access tests, double P2X2/P2X3 purinergic receptor null mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors.

  19. P2X3-/- DRG neurons lacked rapidly desensitizing response to ATP, and both DRG and nodose neurons from P2X3-null mutant mice no longer responded to alpha,beta-methylene ATP (alphabetameATP).

  20. P2X3-mediated responses in dorsal root ganglion neurons were changed in the A/J inbred mouse strain, suggesting that the downregulation of sensory P2X3 might cause low sensitivity to tissue injury pain.

Zebrafish Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Interaktionspartner

  1. Expressed in overlapping, but unique, patterns of sensory neurons in the developing zebrafish.

Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 (P2RX3) Protein Überblick

Protein Überblick

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.

Genbezeichner und Symbole assoziert mit P2RX3

  • purinergic receptor P2X 3 (P2RX3)
  • purinergic receptor P2X 3 (P2rx3)
  • purinergic receptor P2X, ligand-gated ion channel, 3 (P2rx3)
  • purinergic receptor P2X, ligand-gated ion channel, 3a (p2rx3a)
  • 4930513E20Rik Protein
  • fb99b08 Protein
  • p2rx3 Protein
  • p2x3 Protein
  • wu:fb99b08 Protein
  • zfP2X3 Protein
  • zP2X3 Protein

Bezeichner auf Proteinebene für P2RX3

ATP receptor , P2X purinoceptor 3 , P2X receptor, subunit 3 , purinergic receptor P2X3 , purinoceptor P2X3 , P2X3 , purinergic receptor P2X, ligand-gated ion channel, 3 , P2X3 purinoceptor , zP2X3.1

GENE ID SPEZIES
5024 Homo sapiens
81739 Rattus norvegicus
228139 Mus musculus
428856 Gallus gallus
448782 Canis lupus familiaris
530468 Bos taurus
742961 Pan troglodytes
58147 Danio rerio
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