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The product of P2RX3 belongs to the family of purinoceptors for ATP. Zusätzlich bieten wir Ihnen Purinergic Receptor P2x, Ligand-Gated Ion Channel, 3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal P2RX3 Primary Antibody für IHC, IHC (fro) - ABIN250462
Kaan, Yip, Patel, Davies, Marchand, Cockayne, Nunn, Dickenson, Ford, Zhong, Malcangio, McMahon: Systemic blockade of P2X3 and P2X2/3 receptors attenuates bone cancer pain behaviour in rats. in Brain : a journal of neurology 2010
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Human Polyclonal P2RX3 Primary Antibody für ICC, FACS - ABIN250458
Tamburro, Fredolini, Espina, Douglas, Ranganathan, Ilag, Zhou, Russo, Espina, Muto, Petricoin, Liotta, Luchini: Multifunctional core-shell nanoparticles: discovery of previously invisible biomarkers. in Journal of the American Chemical Society 2011
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Druggable negative allosteric site of P2X3 receptors.
conclude that the inter-subunit salt bridge between E112 and R198 of the head and dorsal fin domains, respectively, serves to control the mobility of these domains during agonist-activation of the hP2X3R
P2X3 expressions in endometriosis endometrium and endometriotic lesions were significantly higher as compared with control endometrium, and positively correlated with pain.
P2X3 receptor expression was up-regulated in neurons from patients with temporal lobe epilepsy.
X-ray crystal structures of the human P2X3 receptor in apo (zeige C9orf3 Antikörper)/resting, agonist-bound/open-pore, agonist-bound/closed-pore/desensitized and antagonist-bound/closed states
there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor (zeige P2RX7 Antikörper) in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.
Data show that monoclonal antibodies directed against human P2X3 (12D4) potentiated the slow inactivating current mediated by the heteromeric purinergic receptor (zeige P2RX1 Antikörper) hP2X2/3 channel.
Data indicate P2X3 purinergic receptors as potential new targets for hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) therapy.
Results demonstrate that the stoichiometry of the heterotrimeric hP2X2/3 receptor is not fixed, but determined by the relative availability of P2X2 (zeige P2RX2 Antikörper) and P2X3 subunits
Urothelial P2X3 receptors decreased significantly in responders after Lipotoxin instillation, but not after BoNT-A injection.
This study demonstrated that the P2X3-immunoreactive nerve endings in the rat tracheal mucosa have unique morphological characteristics, and these endings may be rapidly adapting receptors and/or irritant receptors that are activated by mucosal irritant stimuli.
Data suggest that the negative inhibition of P2X3R activity by the BNP (zeige BNC2 Antikörper)/NPR-A (zeige NPR1 Antikörper) pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype.
P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide (zeige BNP Antikörper) and facilitatory calcitonin gene-related peptide (zeige CALCA Antikörper) that both operate via complex intracellular signaling.
mouse trigeminal neurons endogenous BNP (zeige BNC2 Antikörper) acts on NPR-A (zeige NPR1 Antikörper) receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP (zeige BNC2 Antikörper)/NPR-A (zeige NPR1 Antikörper)/PKG (zeige PRKG1 Antikörper) pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments
This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2 (zeige P2RX2 Antikörper)/P2X3 knockout mice.
a slow modulatory action by BNP (zeige BNC2 Antikörper) on TRPV1 (zeige TRPV1 Antikörper) and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli
P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin
genetic manipulation of TRPV1 (zeige TRPV1 Antikörper) and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally.
up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP (zeige CALCA Antikörper) and BDNF (zeige BDNF Antikörper) levels
Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article]
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage.
purinergic receptor P2X, ligand-gated ion channel, 3
, P2X3 purinoceptor
, purinergic receptor P2X3
, ATP receptor
, P2X purinoceptor 3
, P2X receptor, subunit 3
, purinoceptor P2X3