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PUS1 encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. Zusätzlich bieten wir Ihnen Pseudouridylate Synthase 1 Antikörper (50) und und viele weitere Produktgruppen zu diesem Protein an.
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Collectively, these results suggest that alterations in muscle metabolism related to mitochondrial content and oxidative capacity may account for the reduced exercise capacity in Pus1(-/-) mice.
Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (zeige RARA Proteine) (mRAR)gamma when coexpressed with steroid receptor (zeige ESR2 Proteine) RNA activator.
Pus1p- and Pus3p-dependent pseudouridylation of SRA (zeige MSR1 Proteine) controls a coactivator-corepressor switch in SRA (zeige MSR1 Proteine) with major consequences for NR signaling.
results show that the NTD of ERalpha (zeige ESR1 Proteine) and AR contains a novel RBM (zeige RBMY1A1 Proteine) that directly binds SRA (zeige SRA1 Proteine), and that STR5 can serve as a novel class of RNA inhibitor of ERalpha (zeige ESR1 Proteine) and AR signaling by interfering with Pus1p-mediated SRA (zeige SRA1 Proteine) pseudouridylation
We identified one novel homozygous null mutation in a familial case. It predicts a nonsense mutation at glutamine 154 (Q154X) that would lead to a protein lacking the 266 C-terminal amino acids
Missense mutation in pseudouridine synthase 1 causes mitochondrial myopathy and sideroblastic anemia
This gene encodes a pseudouridine synthase that converts uridine to pseudouridine once it has been incorporated into an RNA molecule. The encoded enzyme may play an essential role in tRNA function and in stabilizing the secondary and tertiary structure of many RNAs. A mutation in this gene has been linked to mitochondrial myopathy and sideroblastic anemia. Alternate splicing results in multiple transcript variants.
pseudouridylate synthase 1
, tRNA pseudouridine synthase A, mitochondrial
, tRNA pseudouridine(38-40) synthase
, tRNA pseudouridylate synthase I
, tRNA-uridine isomerase I
, mitochondrial tRNA pseudouridine synthase A
, tRNA uridine isomerase I
, pseudouridine synthase 1