Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Proteine (PTPRN2)

The protein encoded by PTPRN2 is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Antikörper (64) und Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTPRN2 5799 Q92932
PTPRN2 19276 P80560
PTPRN2 29714 Q63475
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,653.83
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PTPRN2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Weitere Proteine zu Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Interaktionspartnern

Human Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Interaktionspartner

  1. Copy-number variations are enriched for PTPRN2 and other neurodevelopmental genes in children with developmental coordination disorder.

  2. Haplotype-dependent allele-specific methylation of PTPRN2 gene is associated with neurological disorders.

  3. Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics.

  4. Data indicate the X-ray structure of the mature ectodomain of mature ectodomain of phogrin/IA-2beta (PTPRN2) (ME phogrin) at pH 7.4 and 4.6.

  5. ProPTPRN2 elicited these effects through direct interaction with TRAF2 (zeige TRAF2 Proteine).

  6. While PTPRN2 shares sequence similarity with protein tyrosine phosphatases, this study in rat suggests that this protein instead functions as a membrane bound phosphatidylinositol phosphatase.

  7. The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 (zeige HOXA1 Proteine) mutations.

  8. IA-2beta is involved in insulin (zeige INS Proteine) secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.

  9. In mice IA-2beta expressed exclusively in dense core secretory vesicles (DCV) and with fractions rich in synaptic vesicles (SV) of neuroendocrine cells of brain and impairment of conditioned learning.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Interaktionspartner

  1. The deletion of IA-2 (zeige PTPRN Proteine) and IA-2beta results in multiple pathophysiologic changes and represents a unique in vivo model for studying the effect of hormone and neurotransmitter reduction on known and still unrecognized targets.

  2. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2 (zeige PTPRN Proteine), IA-2beta, and GAD65 (zeige GAD2 Proteine) enzyme.

  3. Membrane-proximal ectodomain of phogrin was produced as a recombinant protein and characterized' results showed that it is a properly folded monomeric domain.

  4. IA-2beta is involved in insulin (zeige INS Proteine) secretion, but despite its importance as a major autoantigen in human type 1 diabetes, it is not required for the development of diabetes in NOD mice.

  5. phogrin is recycled in Min6 beta-cells

  6. analysis of a tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin

  7. experiments show that the dense core vesicle proteins IA-2 (zeige PTPRN Proteine) and IA-2beta, alone or in combination, are involved in insulin (zeige INS Proteine) secretion, but neither alone nor in combination are they required for the development of diabetes in NOD mice

  8. IA-2beta, but not IA-2 (zeige PTPRN Proteine), is induced by ghrelin (zeige GHRL Proteine) and inhibits glucose-stimulated insulin (zeige INS Proteine) secretion

  9. IA-2 (zeige PTPRN Proteine) and IA-2beta are dispensable for exocytosis of insulin (zeige INS Proteine) granules, but are probably more important for cargo loading and/or stability of dense core vesicles

  10. Phogrin and IA-2 (zeige PTPRN Proteine) function as essential regulators of autocrine insulin (zeige INS Proteine) action in pancreatic beta-cells.

Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 (PTPRN2) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Genbezeichner und Symbole assoziert mit PTPRN2

  • protein tyrosine phosphatase, receptor type N2 (PTPRN2)
  • protein tyrosine phosphatase, receptor type, N polypeptide 2 (Ptprn2)
  • protein tyrosine phosphatase, receptor type N2 (Ptprn2)
  • 4930425H11Rik Protein
  • IA-2beta Protein
  • IA2beta Protein
  • IAR Protein
  • ICAAR Protein
  • mKIAA0387 Protein
  • phogrin Protein
  • Phol Protein
  • PTP-NP Protein
  • PTPRP Protein
  • R-PTP-N2 Protein

Bezeichner auf Proteinebene für PTPRN2

IAR/receptor-like protein-tyrosine phosphatase , islet cell autoantigen-related protein , phogrin , protein tyrosine phosphatase receptor pi , receptor-type tyrosine-protein phosphatase N2 , tyrosine phosphatase IA-2 beta , IA-2 beta , PTP IA-2beta , R-PTP-N2 , protein tyrosine phosphatase-NP , PTP NE-6 , PTPNE6 , protein tyrosine phosphatase receptor-type N polypeptide 2 , protein tyrosine phosphatase, receptor-type, N polypeptide 2

GENE ID SPEZIES
5799 Homo sapiens
616515 Bos taurus
19276 Mus musculus
29714 Rattus norvegicus
Ausgewählte Anbieter für Protein tyrosine Phosphatase, Receptor Type, N Polypeptide 2 Proteine (PTPRN2)
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