Protein tyrosine Phosphatase, Receptor Type, E Proteine (PTPRE)

Human Protein tyrosine Phosphatase, Receptor Type, E (PTPRE) Interaktionspartner

1. these data demonstrate that HCV infection reduces PTPRE expression in the liver and peripheral blood mononuclear cell sof (zeige GJA1 Proteine) infected humans

2. Epidermal growth factor receptor (EGFR (zeige EGFR Proteine))-mediated positive feedback of protein-tyrosine phosphatase epsilon (PTPepsilon) on ERK1/2 and AKT (zeige AKT1 Proteine) protein pathways is required for survival of human breast cancer cells.

3. Studies indicate that RAD50 (zeige RAD50 Proteine) and PTPRE of crude associations with asthma at a Bonferroni-corrected level of significance, while IL4R (zeige IL4R Proteine), CCL5 (zeige CCL5 Proteine) and TBXA2R (zeige TBXA2R Proteine) of nominal significance.

4. Transfection of cells with different PTPepsilon constructs and activator protein-1 (zeige FOSB Proteine) reporter gene indicates that the catalytic activity of PTPepsilon is involved in the regulation of the mitogen-activated protein kinase (zeige MAPK1 Proteine) cascade.

5. Characterization, expression and functional aspects of an alternative spliced isoform of protein tyrosine phosphatase epsilon

6. interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs (zeige PTPRS Proteine)

7. Functions to prevent inappropriate activation and to terminate prolonged, rather than acute, activation of ERK (zeige EPHB2 Proteine) in the cytosol.

8. cyt-PTP epsilon is dimerized and phosphorylated in the absence of direct interaction between the PTP and extracellular molecules

9. Transgenic mice overexpressing catalytically inactive transmembrane protein tyrosine phosphatase epsilon provide unexpected insight into the cell-cell interactions that occur between oligodendrocytes and the cells which they myelinate.

10. Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, E (PTPRE) Interaktionspartner

1. GRB2 (zeige GRB2 Proteine) physically links cyt (zeige CYGB Proteine)-PTPe with Src (zeige SRC Proteine) and enables cyt (zeige CYGB Proteine)-PTPe to activate Src (zeige SRC Proteine) downstream of activated integrins in osteoclast-like cells.

2. PTPs (zeige PTS Proteine) alpha and epsilon play distinct roles in osteoclasts.

3. Multifaceted modulation of K+ channels by protein-tyrosine phosphatase epsilon tunes neuronal excitability.

4. Integrin activation regulates cyt (zeige CYGB Proteine)-PTPe via Src (zeige SRC Proteine)-dependent Y638 phosphorylation. cyt (zeige CYGB Proteine)-PTPe affects osteoclast podosome stability by a feedback loop ensuring proper Src (zeige SRC Proteine) activation downstream of integrins, linking their signaling with Src (zeige SRC Proteine) activation.

5. Findings demonstrate that PTPalpha (zeige PTPRA Proteine) is a critical regulator of Fyn (zeige FYN Proteine) activation and of specific Fyn (zeige FYN Proteine) signaling events during differentiation, and is essential for promoting OPC differentiation and central nervous system myelination.

6. RPTPepsilon is a physiological activator of Src in Neu-induced mammary tumors.

7. cyt-PTP epsilon is dimerized and phosphorylated in the absence of direct interaction between the PTP and extracellular molecules

8. PTPepsilon as a phosphatase required for optimal structure, subcellular organization, and function of osteoclasts

9. Receptor-like protein tyrosine phosphatase (zeige ACP1 Proteine) zeta/RPTP beta (zeige PTPRB Proteine) is expressed on tangentially aligned neurons in early mouse neocortex.

10. Protein tyrosine phosphatase epsilon activates Yes and Fyn (zeige FYN Proteine) in mammary tumor cells.