Protein tyrosine Phosphatase, Receptor Type, B Proteine (PTPRB)

The protein encoded by PTPRB is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen PTPRB Antikörper (24) und PTPRB Kits (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTPRB 314843  
PTPRB 5787 P23467
PTPRB 19263 B2RU80
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Top PTPRB Proteine auf antikoerper-online.de

Showing 8 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Escherichia coli (E. coli) Human His-SUMO Tag   100 μg Anmelden zum Anzeigen 11 Days
$411.40
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Hefe Human His tag   100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$484.00
Details
Escherichia coli (E. coli) Ratte His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details

PTPRB Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Rat (Rattus)

Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) Interaktionspartnern

Human Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) Interaktionspartner

  1. PTPRB was down-regulated in non-small-cell lung cancer patients and was associated with patient overall survival.

  2. STIM1 (zeige STIM1 Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signaling activates Pyk2 (zeige PTK2B Proteine) to inhibit the interaction of VE-PTP and VE-cadherin (zeige CDH5 Proteine) and hence increase endothelial permeability.

  3. Results provide evidence that PTPRB and PLCG1 (zeige PLCG1 Proteine) mutations are driving events in a subset of secondary angiosarcomas.

  4. VE-PTP activates TIE2 (zeige TEK Proteine) and stabilizes retinal and choroidal blood vessels

  5. these results suggest that the polarized redistribution of VE-PTP in response to shear stress plays an important role in the regulation of endothelial cells function by blood flow.

  6. The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored predominantly truncating mutations in 10 of 39 angiosarcoma tumors.

  7. zinc(II) ions regulate receptor protein-tyrosine phosphatase (zeige PTPRT Proteine) beta activity at picomolar concentrations.

  8. vascular endothelial protein tyrosine phosphatase contributes to endothelial morphogenesis. Silencing of VE-PTP expression was accompanied by increased VEGF receptor-2 tyrosine phosphorylation and activation of downstream signaling pathways.

  9. Suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis.

  10. The PTP1B (zeige PTPN1 Proteine) has been observed over expressed in human breast cancer patients, suggesting its role in cell proliferation.

Mouse (Murine) Protein tyrosine Phosphatase, Receptor Type, B (PTPRB) Interaktionspartner

  1. VEPTP (vascular endothelial protein tyrosine phosphatase) determines TIE2 (zeige TEK Proteine) response to ANGPT2 (zeige ANGPT2 Proteine). VEPTP is absent from lymphatic endothelium in mouse in vivo, permitting ANGPT2 (zeige ANGPT2 Proteine)/TIE2 (zeige TEK Proteine)-mediated lymphangiogenesis.

  2. PTPRB regulates branching morphogenesis in the mammary epithelium by modulating the response of the FGFR (zeige FGFR2 Proteine) signalling pathway to FGF stimulation

  3. STIM1 (zeige STIM1 Proteine)-induced Ca(2 (zeige CA2 Proteine)+) signaling activates Pyk2 (zeige PTK2B Proteine) to inhibit the interaction of VE-PTP and VE-cadherin (zeige CDH5 Proteine) and hence increase endothelial permeability.

  4. In the absence of Tie-2 (zeige TEK Proteine), VE-PTP inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin (zeige CDH5 Proteine)-supportive effect of VE-PTP.

  5. The Lewis X (zeige FUT4 Proteine) epitope is mainly expressed on phosphacan (zeige PTPRZ1 Proteine)/receptor protein tyrosine phosphatase (zeige PTPRT Proteine) beta (RPTPbeta) in the developing mouse brain.

  6. VE-PTP activates TIE2 (zeige TEK Proteine) and stabilizes retinal and choroidal blood vessels

  7. We suggest that lymphocyte binding to vascular cell adhesion molecule 1 (zeige VCAM1 Proteine) triggers a signaling process that enables a VE-PTP substrate to dissociate VE-PTP from VE-cadherin (zeige CDH5 Proteine), thereby facilitating efficient transmigration.

  8. We conclude that the role of Tie2 (zeige TEK Proteine) in maintenance of vascular quiescence involves VE-PTP-dependent dephosphorylation of VEGF receptor-2, and that VEGF receptor-2 activity regulates VE-cadherin (zeige CDH5 Proteine) tyrosine phosphorylation, endothelial cell polarity

  9. IGFBP-2 bound receptor protein tyrosine phosphatase (zeige PTPRT Proteine) beta, which led to its dimerization and inactivation. Analysis of aortas obtained from IGFBP-2(-/-) mice showed that receptor protein tyrosine phosphatase (zeige PTPRT Proteine) beta was activated.

  10. Suggest that VE-PTP, in cooperation with integrins, regulates the spreading and migration of endothelial cells during angiogenesis.

PTPRB Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PTPRB

  • protein tyrosine phosphatase, receptor type B (PTPRB)
  • receptor-type tyrosine-protein phosphatase beta (LOC100380677)
  • protein tyrosine phosphatase, receptor type, B (Ptprb)
  • protein tyrosine phosphatase, receptor type B (Ptprb)
  • 3230402H02Rik Protein
  • C130094E24 Protein
  • HPTP-BETA Protein
  • HPTPB Protein
  • PTPB Protein
  • PTPRB Protein
  • Ptpz Protein
  • R-PTP-BETA Protein
  • Rptpb Protein
  • VE-PTP Protein
  • Veptp Protein

Bezeichner auf Proteinebene für PTPRB

protein tyrosine phosphatase, receptor type, B , Receptor-type tyrosine-protein phosphatase beta , receptor-type tyrosine-protein phosphatase beta-like , receptor-type tyrosine-protein phosphatase beta , VE-PTP , protein tyrosine phosphatase, receptor type, beta polypeptide , vascular endothelial protein tyrosine phosphatase , R-PTP-beta , protein-tyrosine phosphatase beta

GENE ID SPEZIES
718564 Macaca mulatta
100063580 Equus caballus
100380677 Salmo salar
100456419 Pongo abelii
100548729 Meleagris gallopavo
100582561 Nomascus leucogenys
314843 Rattus norvegicus
5787 Homo sapiens
19263 Mus musculus
100350989 Oryctolagus cuniculus
100720273 Cavia porcellus
100156181 Sus scrofa
481162 Canis lupus familiaris
505696 Bos taurus
417853 Gallus gallus
101121760 Ovis aries
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