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PROS encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. Zusätzlich bieten wir Ihnen PROS1 Antikörper (169) und PROS1 Kits (55) und viele weitere Produktgruppen zu diesem Protein an.
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Human PROS1 Protein expressed in HEK-293 Cells - ABIN2729817
Kariolis, Miao, Jones, Kapur, Mathews, Giaccia, Cochran: An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. in Nature chemical biology 2014
The present case combined with the review of the literature suggests that p.Arg451* in the PROS1 (zeige PROS1 zeige) gene mainly leads to clinically evident thrombosis following trauma, surgery or serious comorbidities especially malignancy.
Protein S and Gas6 (zeige GAS6 Proteine) mediates phagocytosis of HIV-1-infected cells by bridging receptor tyrosine kinase (zeige RET Proteine) Mer (zeige MERTK Proteine) to phosphatidylserine exposed on infected cells.
these results suggest a novel pathogenic role of SPE B that initiates protein S degradation followed by the inhibition of apoptotic cell clearance by macrophages
Developed functional protein S assays that measure both the activated protein C (zeige PROC Proteine)- and TFPI (zeige TFPI Proteine)-cofactor activities of protein S in plasma, which are hardly if at all affected by the FV Leiden mutation.
Taken together, our gain-of-function, loss-of-function analyses suggest that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa (zeige FLVCR1 Proteine)-like cells via its apoptosis-regulating property.
we identify PROS1 (zeige PROS1 Proteine) as a driver of Oral Squamous Cell Carcinoma tumor growth and a modulator of AXL (zeige AXL Proteine) expression
The prevalence of PS de fi ciency in the present study was higher than in Western countries and con (zeige DISP1 Proteine) fi rms the high prevalence of PS de fi ciency in Asian populations
In the present study, gene analysis of six unrelated Japanese families diagnosed with congenital protein S deficiency identified five missense mutations in the PROS1 (zeige PROS1 zeige) gene - c.757C>T (Ala139Val; A139V), c.1346 G>T (Cys449Phe; C449F), c.1352G>A (Arg451Gln; R451Q), c.1424G>T (Cys475Phe; C475F) and c.1574C>T (Ala525Val; A525V) - and one frameshift mutation, c.2135delA (Asp599ThrfsTer13; D599TfsTer13).
The odds ratio of developing idiopathic fatal pulmonary embolism as a variant carrier for PROS1 (zeige PROS1 zeige) is 56.4 (95% CI, 5.3-351.1; P = 0.001).
described a novel PROS1 (zeige PROS1 zeige) frameshift mutation, c.74dupA, in a hereditary protein S deficiency family. Interestingly, both of the proband and his mother carried the mutation and had a protein S deficiency, however, only the proband suffered a pulmonary embolism while his mother had no history of any thrombosis, suggesting that a triggering event might have been involved in the thrombus formation.
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3.
, vitamin K-dependent plasma protein S
, vitamin K-dependent protein S