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PPP6C encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Zusätzlich bieten wir Ihnen Protein Phosphatase 6, Catalytic Subunit Antikörper (73) und viele weitere Produktgruppen zu diesem Protein an.
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findings define the WHIP (zeige WRNIP1 Proteine)-TRIM14 (zeige TRIM14 Proteine)-PPP6C mitochondrial signalosome required for RIG-I (zeige DDX58 Proteine)-mediated innate antiviral immunity.
Knockdown of Alpha4 preferentially impacts the expression of PP4c (zeige PPP4C Proteine) and PP6c compared to expression levels of PP2Ac (zeige PPP2CA Proteine).
findings suggest that BRCA1 is a novel modulator of PP6 signalling via its interaction with ANKRD28.
Data show 408 phosphopeptides on 272 proteins that increased and 298 phosphopeptides on 220 proteins that decreased in phosphorylation upon catalytic subunit of rotein phosphatase 6 (PP6c) depletion in mitotic cells.
Protein phosphatase 6 ( (zeige NFKB1 Proteine)ppp6c), a ne (zeige MLXIP Proteine)gative regulator that restricts the G1 to S phase progression, is diminished in human psoriatic epidermis and is directly targeted by miR-31.
PP6 is involved in a diverse set of biological pathways.
These results suggest that human PP6 interacts with and positively regulates the activity of the influenza A virus RNA-dependent RNA polymerase.
PP6C mutations have distinct functional and clinical consequences in melanoma, and confer sensitivity to Aurora A kinase (zeige AURKA Proteine) inhibitors.
PP6c associates with E-cadherin (zeige CDH1 Proteine) in adherens junctions and is required to oppose casein kinase-1 (zeige CSNK1A1 Proteine) to maintain cell surface localization of E-cadherin (zeige CDH1 Proteine).
Findings support the view that formation of micronuclei rather than chromosome instability alone explains how loss of PPP6C, and more generally mitotic spindle and centrosome defects, can act as drivers for genome instability in melanoma.
the Ppp6c phosphatase domain is indispensable for mouse embryogenesis after implantation.
findings uncover a hitherto unknown role for PP6 as an indispensable regulator of oocyte meiosis and female fertility.
Data identify NF-kappaB (zeige NFKB1 Proteine)-induced miR (zeige MLXIP Proteine)-31 and its target, ppp6c, as critical factors for the hyperproliferation of epidermis in psoriasis.
Ppp6c deficiency predisposes mice to skin carcinogenesis initiated by DMBA.
Ppp6c deficiency underlies molecular events that drive outgrowth of initiated keratinocytes harboring UVB-induced mutated p53 (zeige TP53 Proteine)
Our studies demonstrate that PP6 acts as a critical negative regulator of naive T cell homeostasis
PP6 regulates the sensitivity of GBM cells to radiation, and suggest small molecules disrupting or inhibiting PP6 association with DNA-PK is a potential radiosensitizer for GBM.
alpha4 expression differentially increased or decreased phosphorylation of endogenous phosphoproteins, consistent with opposing effects on PP2A (zeige PPP2R2B Proteine) and PP6 [PP6]
This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
serine/threonine protein phosphatase catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit
, protein phosphatase V
, protein phosphatase 6, catalytic subunit
, serine/threonine-protein phosphatase 6 catalytic subunit-like