Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
PPP4R1 encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4).
Showing 4 out of 4 products:
Data identify PP4R1 as a novel target for virus subversion of the host anti-viral response.
PP4R1 could mediate the dephosphorylation of TRAF2 (zeige TRAF2 Proteine) Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK (zeige CHUK Proteine) activity, T cell hyperactivation, and aberrant NF-kappaB (zeige NFKB1 Proteine) signaling in NF-kappaB (zeige NFKB1 Proteine)-addicted T cell lymphomas
LCMT-1 (zeige LCMT1 Proteine) homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3 (zeige HDAC3 Proteine), a reported target of the methylation-dependent PP4R1-PP4c (zeige PPP4C Proteine) complex. Collectively, our data suggest that LCMT-1 (zeige LCMT1 Proteine) coordinately regulates the carboxyl methylation of PP2A (zeige PPP2R2B Proteine)-related phosphatases and, consequently, their holoenzyme assembly and function.
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1