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PPP4R1 encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). Zusätzlich bieten wir Ihnen Protein Phosphatase 4, Regulatory Subunit 1 Antikörper (31) und viele weitere Produktgruppen zu diesem Protein an.
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Data identify PP4R1 as a novel target for virus subversion of the host anti-viral response.
PP4R1 could mediate the dephosphorylation of TRAF2 Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK activity, T cell hyperactivation, and aberrant NF-kappaB signaling in NF-kappaB-addicted T cell lymphomas
miR3383p may be involved in TNFalphamediated gluconeogenesis via targeting of PP4R1 in hepatocytes.
LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function.
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1