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PPP1R8, through alternative splicing, encodes three different isoforms. Zusätzlich bieten wir Ihnen Protein Phosphatase 1, Regulatory Subunit 8 Antikörper (105) und Protein Phosphatase 1, Regulatory Subunit 8 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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NIPP1 could be activated by hypoxia and contributed to hypoxia-induced invasive and metastatic potential in hepatocellular carcinoma.
Data suggest overexpression of NIPP1 in HeLa cells causes induction of genes of mesenchymal lineage with reduction in cell proliferation; thus, key dephosphorylation events may be involved in epithelial-mesenchymal transition or transdifferentiation.
PP1/NIPP1 is a novel molecular compass that controls directed cell migration.
The molecular basis by which NIPP1 directs PP1 substrate specificity in the nucleus.
The protein phosphatase-1 regulator NIPP1 is also a splicing factor involved in a late step of spliceosome assembly
NIPP1 has a role in the nuclear targeting and/or retention of PP1
We demonstrate that interaction with NIPP1 mediates decreased PP1gamma activity in hypoxia, an event which may constitute an inherent part of the cellular oxygen-sensing machinery and may play a role in physiologic adaptation to hypoxia.
Required for the global trimethylation of histone3 at lysine27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2.
NIPP1 is present in a complex with EED and EZH2 in vivo and has distinct binding sites for these proteins.
NMR structure of the NIPP1 FHA domain.
NIPP1 works as a molecular sensor for PP1 to recognize phosphorylated Sap155.
NIPP1 does not regulate the proliferation of hepatocytes but is a suppressor of biliary epithelial cell proliferation, including progenitor cells, in the adult liver.
activation of the RAGE by advanced glycation end products or other ligands suppresses NIPP1 expression in diabetic nephropathy, contributes to podocyte hypertrophy, and glomerular inflammation
NIPP1(-/-) embryos showed severely retarded growth at embryonic day 6.5 (E6.5) and were resorbed by E8.5. This early embryonic lethality was not associated with increased apoptosis but correlated with impaired cell proliferation.
Required for the global trimethylation of Histone 3 at Lysine 27 and is implicated in gene silencing by enhancer of zeste homolog (EZH)2.
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA.
, activator of RNA decay
, nuclear inhibitor of protein phosphatase 1
, nuclear inhibitor of protein phosphatase-1 alpha
, nuclear subunit of PP-1
, protein phosphatase 1 regulatory subunit 8
, protein phosphatase 1, regulatory (inhibitor) subunit 8
, protein phosphatase 1 regulatory inhibitor subunit 8
, protein phosphatase 1, regulatory inhibitor subunit 8
, uncharacterized protein LOC799896
, protein phosphatase 1, regulatory (inhibitor) subunit 8a
, protein phosphatase 1, regulatory subunit 8a
, protein phosphatase 1 regulatory subunit 8 S homeolog