Protein Phosphatase 1, Regulatory Subunit 16B Proteine (PPP1R16B)

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP is suppressed by TGFbeta via HDAC3-associated Smad signaling.

2. These data confirmed the barrier-protective role of TIMAP

3. mRNA is located in cell bodies and dendrites of neurons in four distinct regions of the brain.

Human Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP is the versatile protein phosphatase 1 regulator in endothelial cells. (Review)

2. NF2 localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 to TIMAP and EBP50 is critical in nuclear localization of NF2. (NF2 = neurofibromin 2; TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 = Ezrin-Radixin-Mosein binding phosphoprotein 50)

3. phosphorylation of TIMAP on Ser331 by PKC represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM dephosphorylation

4. Results indicate that PKC-phosphorylated ECE-1 is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 production of EC through the regulation of ECE-1 activity.

5. ROCK phosphorylated eEF1A1 is a novel substrate for TIMAP-PP1 underlining the complex regulatory role of TIMAP in the endothelium.

6. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells.

7. These data confirmed the barrier-protective role of TIMAP

8. Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.

9. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells.

10. involvement of TIMAP in PKA-mediated moesin dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection

Cow (Bovine) Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP can modify protein phosphorylation independent of its function as a PP1c regulatory subunit, namely by masking phosphorylation sites of binding partners like PP1c and LAMR1.

2. TIMAP is a target for PKA-primed GSK-3beta-mediated phosphorylation. This phosphorylation controls TIMAP association and activity of PP1c