Protein Phosphatase 1, Regulatory Subunit 16B Proteine (PPP1R16B)

Mouse (Murine) Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP is suppressed by TGFbeta (zeige TGFB1 Proteine) via HDAC3 (zeige HDAC3 Proteine)-associated Smad (zeige SMAD1 Proteine) signaling.

2. These data confirmed the barrier-protective role of TIMAP

Human Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP is the versatile protein phosphatase 1 (zeige PPP1CB Proteine) regulator in endothelial cells. (Review)

2. NF2 (zeige NF2 Proteine) localizes in nucleus when Ser518 is not phosphorylated, while phosphorylated form is present in cytoplasm and plasma membrane. Data suggest that binding of NF2 (zeige NF2 Proteine) to TIMAP and EBP50 (zeige SLC9A3R1 Proteine) is critical in nuclear localization of NF2 (zeige NF2 Proteine). (NF2 (zeige NF2 Proteine) = neurofibromin 2 (zeige NF2 Proteine); TIMAP = TGF-beta-inhibited membrane-associated protein; EBP50 (zeige SLC9A3R1 Proteine) = Ezrin (zeige EZR Proteine)-Radixin (zeige RDX Proteine)-Mosein binding phosphoprotein 50)

3. phosphorylation of TIMAP on Ser331 by PKC (zeige PRRT2 Proteine) represents a new mechanism of endothelial barrier regulation, through the inhibition of phospho-ERM (zeige ETV5 Proteine) dephosphorylation

4. Results indicate that PKC (zeige PRRT2 Proteine)-phosphorylated ECE-1 (zeige ECE1 Proteine) is a TIMAP-PP1c substrate and this phosphatase complex has an important role in endothelin-1 (zeige EDN1 Proteine) production of EC through the regulation of ECE-1 (zeige ECE1 Proteine) activity.

5. ROCK phosphorylated eEF1A1 (zeige EEF1A1 Proteine) is a novel substrate for TIMAP-PP1 (zeige PPA1 Proteine) underlining the complex regulatory role of TIMAP in the endothelium.

6. TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt (zeige AKT1 Proteine) inhibition in human glomerular endothelial cells.

7. These data confirmed the barrier-protective role of TIMAP

8. Data suggest that double-thiophosphorylation of TIMAP has minor effect on its binding ability to PP1c, but considerably attenuates its inhibitory effect on the activity of PP1c.

9. TIMAP, a novel CAAX box protein regulated by TGF-beta1 (zeige TGFB1 Proteine) and expressed in endothelial cells.

10. involvement of TIMAP in PKA-mediated moesin (zeige MSN Proteine) dephosphorylation and the importance of this dephosphorylation in TIMAP-mediated endothelial cell barrier protection

Cow (Bovine) Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B) Interaktionspartner

1. TIMAP can modify protein phosphorylation independent of its function as a PP1c regulatory subunit, namely by masking phosphorylation sites of binding partners like PP1c and LAMR1 (zeige RPSA Proteine).

2. TIMAP is a target for PKA-primed GSK-3beta-mediated phosphorylation. This phosphorylation controls TIMAP association and activity of PP1c