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IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53\; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen Protein Phosphatase 1, Regulatory Subunit 13 Like Antikörper (71) und Protein Phosphatase 1, Regulatory Subunit 13 Like Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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miR (zeige MLXIP Proteine)-182 plays an aggressive role in the cerebral ischemia injury, and this is associated with inhibited iASPP expression.
iASPP expression may act as a predictive marker of prostate cancer progression.
These data demonstrate that by interacting with desmoplakin and desmin (zeige DES Proteine), iASPP is an important regulator of desmosomal function both in vitro and in vivo.
p53 (zeige TP53 Proteine)-mediated neuronal cell death after stroke can be nontranscriptionally regulated by a novel mechanism involving suppression of endogenous cell death inhibitors by miR (zeige MLXIP Proteine)-124.
PPP1R13L has an essential role in embryonic eyelid closure as well in development of meibomian glands and the anterior segment of the eye
These data showed iASPP to be a key regulator of epithelial homeostasis in skin.
Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.
Mice with mutation in Nkip1 (Ppp1r13l) represent a potentially important model for the analysis of the role of inflammatory processes in heart disease.
Studies revealed that overexpression of PPP1R13L causes faster p53 (zeige TP53 Proteine) degradation, a likely explanation for the depletion of p53 (zeige TP53 Proteine).
Haplotypes consisting of PPP1R13L rs1970764 and ATM rs11212592 may be associated with lung cancer. Haplotypes consisting of PPP1R13L, CD3EAP and GLTSCR1 SNPs on Chr19q13.3 may associate with lung cancer risk in the Chinese population.
The expression of CD3EAP (zeige CD3EAP Proteine) exon 1 was demonstrated to be significantly associated with PPP1R13L exon 1, while CD3EAP (zeige CD3EAP Proteine) exon 3 was significantly associated with ERCC1 (zeige ERCC1 Proteine) exon 11 in normal and non-small cell lung cancer (NSCLC) tissues. It was observed that short transcripts of ERCC1 (zeige ERCC1 Proteine), CD3EAP (zeige CD3EAP Proteine) and PPP1R13L are co-expressed in A549 NSCLC cell line.
Increased expression of miR (zeige MLXIP Proteine)-150 suppressed viability, proliferation, migration and invasion of SW480 cells. Furthermore, iASPP was a direct target of miR (zeige MLXIP Proteine)-150 and played a key role in its anti-colorectal cancer (CRC (zeige CALR Proteine))function. miR (zeige MLXIP Proteine)-150 may be a promising predictor of prognosis in CRC (zeige CALR Proteine) patients.
IASPP knockdown suppressed cell viability and DNA synthesis capacity; the effect of miR (zeige MLXIP Proteine)-340 inhibition was partially attenuated by iASPP inhibition.
The expression of iASPP was higher in highgrade astrocytic gliomas compared with lowgrade astrocytic gliomas.
Data showed that iASPP could promote tumor growth by increasing autophagic flux, and iASPP could serve as a poor prognostic factor and a potential therapeutic target in lung cancer.
Sertad1 (zeige SERTAD1 Proteine) could antagonize iASPP function by hindering its entrance into nuclei to interact with P53 (zeige TP53 Proteine) in leukemic cells when iASPP was in the stage of overproduction.
The interactive modulation among miR (zeige MLXIP Proteine)-124 and iASPP in p53 (zeige TP53 Proteine)-mutant or -deleted cells may serve as a crucial pathway, which mediates therapy resistance when p53 (zeige TP53 Proteine) is mutated or deleted, in the process of photodynamic therapy treatment of Colorectal cancer.
These findings indicated that XIST may regulate the tumor growth and metastasis via miR (zeige MLXIP Proteine)-140-dependent iASPP regulation. Taken together, our data indicated that XIST may be an oncogenic lncRNA that promotes the proliferation and metastasis of lung cancer through the regulation of miR (zeige MLXIP Proteine)-140 and could be regarded as a therapeutic target in human lung cancer.
FHL2 (zeige FHL2 Proteine) and iASPP interacted with each other and co-localized in both nucleus and cytoplasm. Either FHL2 (zeige FHL2 Proteine) or iASPP silenced could reduce cell proliferation, induce cell cycle arrest at G0/G1 phase, and increase cell apoptosis.
Frameshift mutation in PPP1R13L causes Cardiomyopathy and woolly haircoat syndrome in Poll Hereford cattle.
Data suggest Greatwall (zeige MASTL Proteine) kinase (Gwl (zeige MASTL Proteine)) associates with protein phosphatase 1 (zeige PPP1CB Proteine) (PP1), particularly PP1gamma subunit, which mediates dephosphorylation of Gwl (zeige MASTL Proteine) Ser (zeige SIGLEC1 Proteine)-883; consistent with mitotic activation of Gwl (zeige MASTL Proteine), its association with PP1 is disrupted in mitotic cells; subunits PPP1R3B (zeige PPP1R3B Proteine) and PPP1R13L associate with Gwl (zeige MASTL Proteine); thus, PPP1R3B (zeige PPP1R3B Proteine) appears to act as cell cycle regulator in oocytes that functions by governing Gwl (zeige MASTL Proteine) dephosphorylation.
IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53\; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.
NFkB interacting protein 1
, NFkB-interacting protein 1
, PPP1R13B-like protein
, inhibitor of ASPP protein
, protein iASPP
, relA-associated inhibitor
, inhibitor of apoptosis stimulating protein of p53
, protein phosphatase 1, regulatory (inhibitor) subunit 13 like
, retinoic acid induced 4