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Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine (PPM1A)

The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Zusätzlich bieten wir Ihnen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antikörper (97) und Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PPM1A 5494 P35813
PPM1A 19042 P49443
PPM1A 24666 P20650
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Top Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine auf antikoerper-online.de

Showing 10 out of 19 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$270.00
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$280.50
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$394.90
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$282.13
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

PPM1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus) ,

Weitere Proteine zu Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartnern

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartner

  1. Here the authors establish PPM1A as a checkpoint target used by Mycobacterium tuberculosis to suppress macrophage apoptosis. Overproduction of PPM1A suppressed apoptosis of Mycobacterium tuberculosis-infected macrophages by a mechanism that involves inactivation of the c-Jun N-terminal kinase (JNK).

  2. Present study suggests that HBx-induced degradation of PPM1a is a novel mechanism for over-activation of TGF-beta (zeige TGFB1 Proteine) pathway in HCC (zeige FAM126A Proteine) development.

  3. Findings show that HCV infection and replication decreased PPM1A abundance, mediated by NS3, in hepatoma cells. Compared to normal liver tissues, the expression of PPM1A was significantly decreased in the HCC tumor tissues and adjacent non-tumor tissues through its regulation by NS3 which promotes its ubiquitination and proteasomal degradation.

  4. These data suggest that PPM1A, which had previously been shown to play a role in the antiviral response to Herpes Simplex virus infection, also governs the antibacterial response of macrophages to bacteria, or at least to Mycobacterium tuberculosis infection

  5. establish PPM1A as a novel repressor of the SMAD3 (zeige SMAD3 Proteine) pathway in renal fibrosis

  6. Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 (zeige SMAD4 Proteine) in pancreatic ductal adenocarcinoma.

  7. hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states

  8. In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.

  9. findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 Proteine) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 Proteine)

  10. The TGF-beta (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.

Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Interaktionspartner

  1. VRK1 (zeige VRK1 Proteine) self-represses its activity to phosphorylate PXR (zeige NR1I2 Proteine) through cyclin-dependent kinase 2 (CDK2 (zeige CDK2 Proteine)) in high glucose conditions, resulting in the repression of the PCK1 (zeige PCK1 Proteine) gene. This PXR (zeige NR1I2 Proteine) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1 (zeige VRK1 Proteine)-CDK2 (zeige CDK2 Proteine)-PXR (zeige NR1I2 Proteine)-PP2Calpha-SGK2 (zeige SGK2 Proteine) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.

  2. findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 Proteine) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 Proteine)

  3. the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions

  4. a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 Proteine) signaling in which MAN1 (zeige LEMD3 Proteine) competes with transcription factors for binding to Smad2 (zeige SMAD2 Proteine) and Smad3 (zeige SMAD3 Proteine) and facilitates their dephosphorylation by PPM1A.

  5. Although a non-myristoylated mutation (G2A (zeige GPR132 Proteine)) of PPM1A and PPM1B (zeige PPM1B Proteine) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 Proteine).

  6. we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein

  7. Protein phosphatase PPM1A regulates the nuclear export of Smad2 (zeige SMAD2 Proteine)/3 through targeting nuclear exporter RanBP3 (zeige RANBP3 Proteine).

  8. Ppm1a, through suppressing Smad2 (zeige SMAD2 Proteine) signaling, plays a critical role in re-epithelialization during wound healing

  9. Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)

  10. Protein phosphatase 1alpha is required for lung growth and morphogenesis.

Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A) Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

Genbezeichner und Symbole assoziert mit PPM1A

  • protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A)
  • protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L)
  • protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa)
  • 2310003C21Rik Protein
  • 2900017D14Rik Protein
  • AI427932 Protein
  • AU017636 Protein
  • MMPa-2 Protein
  • MPPa-1 Protein
  • pp2c-alpha Protein
  • Pp2c1 Protein
  • pp2ca Protein
  • pp2ca2 Protein
  • pp2calpha Protein

Bezeichner auf Proteinebene für PPM1A

protein phosphatase 1A , protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform , Mpp alpha , PP2C-alpha , protein phosphatase 2C isoform alpha , protein phosphatase IA , IA , Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform , Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform , protein phosphatase 1A, magnesium dependent, alpha isoform , protein phosphatase 2C alpha , protein phosphatase type 2C alpha 2

GENE ID SPEZIES
5494 Homo sapiens
19042 Mus musculus
24666 Rattus norvegicus
380058 Xenopus laevis
423525 Gallus gallus
480344 Canis lupus familiaris
281994 Bos taurus
100009431 Oryctolagus cuniculus
100738389 Sus scrofa
100734826 Cavia porcellus
30704 Danio rerio
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