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vitamin K-dependent zymogen that acts as a serine protease upon activation; catalyzes the inactivation of blood coagulation cofactors Va and VIIIa.
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Human PROC ELISA Kit für Competition ELISA - ABIN612753
Foster, Yoshitake, Davie: The nucleotide sequence of the gene for human protein C. in Proceedings of the National Academy of Sciences of the United States of America 1985
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Data show that activated protein C signals via protease activated receptors PAR2 (zeige F2RL1 ELISA Kits)/PAR3 (zeige F2RL2 ELISA Kits) to expand Treg cells, mitigating the disease in mice.
insulin (zeige INS ELISA Kits) and aPC (zeige APC ELISA Kits) converge on a common spliced-X-box binding protein-1 (zeige XBP1 ELISA Kits) (sXBP1) signaling pathway to maintain endoplasmic reticulum (ER) homeostasis.
loss of the convertase furin (zeige FURIN ELISA Kits) or PC5 (zeige PCSK5 ELISA Kits)/6 in hepatocytes results in a approximately 30% decrease in APC (zeige APC ELISA Kits) levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin (zeige F2 ELISA Kits) activation.
APC (zeige APC ELISA Kits) modifies pulmonary fibrosis by limiting thrombin (zeige F2 ELISA Kits)-dependent macrophage recruitment.
Small interfering RNA-mediated silencing of protein C in apolipoprotein E (zeige APOE ELISA Kits)-deficient mice creates a condition that allows the occurrence of spontaneous atherothrombosis.
These findings reveal a novel biological function and mechanism of the protein C pathway in which protein S and the aPC (zeige APC ELISA Kits)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC ELISA Kits) in the context of endotoxemia and infection
activated PC-EPCR-PAR1 signaling promotes hematopoietic stem cell retention in bone marrow.
impaired EPCR (zeige PROCR ELISA Kits)/protein C-binding interactions not only result in procoagulant and proinflammatory effects, but also impact hematopoiesis
SOD prevents thrombomodulin (zeige THBD ELISA Kits) methionine oxidation, promotes protein C activation, and protects against arterial and venous thrombosis in mice.
sPLA2 (zeige PLA2G2A ELISA Kits)-V plays a thrombogenic role by impairing the ability of EPCR (zeige PROCR ELISA Kits) to promote protein C activation.
PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important for the integrity of the teeth.
, prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
, anticoagulant protein C
, autoprothrombin IIA
, blood coagulation factor XIV
, inactivator of coagulation factors Va, VIII
, vitamin K-dependent protein C