Protease, serine, 50 Proteine (PRSS50)

Mouse (Murine) Protease, serine, 50 (PRSS50) Interaktionspartner

1. findings indicate that BORIS (zeige CTCFL Proteine)-induced expression of TSP50 is governed by accessibility and binding of BORIS (zeige CTCFL Proteine) to the promoter

2. TSP50 promotes cell proliferation, at least partially, through activation of the NF-kappaB (zeige NFKB1 Proteine) signalling pathway.

3. results showed that downregulation of TSP50 expression in P19 embryonal carcinoma stem cells not only reduced cell proliferation, colony formation, and migration but also induced cell apoptosis

4. TSP50 may perform a critical biologic function in mammalian spermatogenesis. It may be a new type of threonine protease whose linear catalytic structure is similar to many serine proteases, except f (zeige TRH Proteine)or a Thr (zeige SIGLEC1 Proteine)-for-Ser residual catalytic site substitution.

5. These findings suggested that DNA methylation (zeige HELLS Proteine) might regulate the TSP50 and mTSP50 gene expressions in different types of tissues and spermatic cells.

Human Protease, serine, 50 (PRSS50) Interaktionspartner

1. TSP50 promotes the proliferation, migration and invasion of gastric cancer cells involving NF-kappaB (zeige NFKB1 Proteine) dependent EMT (zeige ITK Proteine) activation. Targeting TSP50 may provide a novel therapeutic strategy for the management of gastric cancer

2. human epidermal growth factor receptor (zeige EGFR Proteine) 2 (HER-2 (zeige ERBB2 Proteine)) levels, were correlated well with TSP50/p-Samd2 (zeige SARM1 Proteine)/3 and TSP50/p27 (zeige PAK2 Proteine) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer

3. In patients with Colon cancer, the expression of TSP50 gene was associated with a poor prognosis.

4. TSP50 plays a significant role in NSCLC cell proliferation and may act as a novel oncogene (zeige RAB1A Proteine) in the development and progression of NSCLC.

5. Results suggest that 7P3A, which consists of 70 % 25-methoxyl-dammarane-3beta, 12beta, 20-triol and 30 % artemisinin, exhibits anti-cancer effects, in part, through downregulation of testes-specific protease 50 (TSP50) expression.

6. Results show that TSP50 is up-regulated in laryngocarcinoma tumour tissues and its down-regulation inhibits cell proliferation, reduces cell migration and induces cell apoptosis of laryngocarcinoma in NF-KB mediated pathway.

7. we found that some breast cancer diagnosis-associated features such as tumor size, tumor grade, estrogen receptors (ER) and progesterone receptors (PR) levels, were correlated well with TSP50/p65 (zeige GORASP1 Proteine) and TSP50/MMP9 (zeige MMP9 Proteine) expression status

8. TSP50's threonine protease activity is crucial for its effects on tumor formation.

9. The mutations in the catalytic triad of TSP50 could significantly depressed TSP50-mediated cell proliferation and tumor formation.

10. High TSP50 expression is associated with laryngocarcinoma.