Prostaglandin I2 (Prostacyclin) Synthase Proteine (PTGIS)

PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. Zusätzlich bieten wir Ihnen Prostaglandin I2 (Prostacyclin) Synthase Antikörper (70) und Prostaglandin I2 (Prostacyclin) Synthase Kits (38) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGIS 5740 Q16647
PTGIS 19223 O35074
PTGIS 25527 Q62969
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,417.33
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,421.00
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Escherichia coli (E. coli) Human T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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PTGIS Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartnern

Human Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA (zeige PRDX2 Proteine), 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression

  2. Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.

  3. results indicate that PGIS expression was associated with radiotherapy efficiency

  4. Type-2 diabetes is associated with higher COX-2 expression, but lower eNOS (zeige NOS3 Proteine) and PGIS expression in subcutaneous arteries.

  5. In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.

  6. These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF (zeige VEGFA Proteine) in fibroblasts.

  7. High PTGIS expression is associated with colorectal cancer hepatic metastasis.

  8. The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD

  9. Overexpression of PTGIS is associated with liver metastasis in colon cancer.

  10. diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes

Mouse (Murine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. Prostacyclin synthase and prostaglandin E synthase (zeige PTGES Proteine)-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  2. Cyclooxygenase-2 (zeige PTGS2 Proteine)-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor (zeige F3 Proteine) in a sirtuin-1 (zeige SIRT1 Proteine)-dependent-manner.

  3. CD40 ligand (zeige CD40LG Proteine) might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.

  4. Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2 (zeige PTGIR Proteine)) release but also abolished high-glucose-enhanced PGIS nitration.

  5. Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2 (zeige PTGIR Proteine)) is required to enhance the inhibition of sympathoactivation.

  6. The results provide strong evidence that the protective effects of COX-2 within the liver are mediated through the production of PGE (zeige LIPF Proteine)(2) and PGI(2 (zeige PTGIR Proteine)), which exert anti-inflammatory functions.

  7. Endothelial PGI (zeige BGN Proteine) synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.

  8. identify PGI(2)-prostaglandin I2 receptor (zeige PTGIR Proteine) as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4 (zeige CD4 Proteine)(+) Th2 cells into the inflammatory site

  9. COX-1 (zeige PTGS1 Proteine) contributes to the enhanced formation of both PGI(2 (zeige PTGIR Proteine)) and TXA(2 (zeige TBXA2R Proteine)) in atherosclerosis, and to the development of the disease

  10. PGIS/ IP transgenic animals with lung-specific PPARgamma (zeige PPARG Proteine) overexpression also developed fewer lung tumors.

Zebrafish Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS

Pig (Porcine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.

  2. Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2 (zeige PTGIR Proteine)) synthesis in pregnant animals

  3. CRP (zeige CRP Proteine) stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2 (zeige PTGIR Proteine)) synthesis.

Cow (Bovine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Protein Überblick

Protein Überblick

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Genbezeichner und Symbole assoziert mit PTGIS

  • prostaglandin I2 synthase (PTGIS)
  • prostaglandin I2 (prostacyclin) synthase (Ptgis)
  • prostaglandin I2 (prostacyclin) synthase (ptgis)
  • prostacyclin synthase (VDBG_06319)
  • prostaglandin I2 synthase (Ptgis)
  • Cyp8 Protein
  • Cyp8a1 Protein
  • Pgis Protein
  • PTGI Protein
  • PTGIS Protein
  • ptgisl Protein

Bezeichner auf Proteinebene für PTGIS

cytochrome P450, family 8, subfamily A, polypeptide 1 , prostacyclin synthase , prostaglandin I2 synthase , prostaglandin I2 (prostacyclin) synthase like , prostaglandin I2 (prostacyclin) synthase , cytochrome P450 8A1

GENE ID SPEZIES
5740 Homo sapiens
19223 Mus musculus
559148 Danio rerio
9535224 Verticillium alfalfae VaMs.102
458323 Pan troglodytes
703407 Macaca mulatta
100126284 Sus scrofa
100592236 Nomascus leucogenys
25527 Rattus norvegicus
282021 Bos taurus
100734621 Cavia porcellus
101116418 Ovis aries
100071412 Equus caballus
100856661 Canis lupus familiaris
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