anti-Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Antikörper

PTGIS encodes a member of the cytochrome P450 superfamily of enzymes. Zusätzlich bieten wir Ihnen Prostaglandin I2 (Prostacyclin) Synthase Kits (39) und Prostaglandin I2 (Prostacyclin) Synthase Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PTGIS 5740 Q16647
PTGIS 19223 O35074
PTGIS 25527 Q62969
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Top anti-Prostaglandin I2 (Prostacyclin) Synthase Antikörper auf antikoerper-online.de

Showing 10 out of 66 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-PTGIS Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Human Ziege Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
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Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of CYP8A1 Antibody (C-term) (ABIN652421) in CEM cell line lysates (35 µg/lane). CYP8A1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human prostate carcinoma reacted with PAX3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-CYP8A1 Antibody (N-term) (ABIN392532) in mouse lung tissue lysates (35 µg/lane). CYP8A1(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with CYP8A1 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Western blot analysis of extracts from K562 cells, using PTGIS antibody. ABIN6275809 staining K562 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
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Human Kaninchen Unkonjugiert EIA, WB Formalin-fixed and paraffin-embedded human prostate carcinoma reacted withPTGIS Antibody (C-term) followed which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of PTGIS Antibody (C-term) Cat.-No AP17980PU-N in CEM cell line lysates (35ug/lane). CYP8A1 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Maus Kaninchen Unkonjugiert IHC (p), WB Human Heart (formalin-fixed, paraffin-embedded) stained with PTGIS antibody ABIN214080 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-PTGIS antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml. 1 each Anmelden zum Anzeigen 11 bis 14 Tage
$639.83
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC (p), IP, WB Human Prostate (formalin-fixed, paraffin-embedded) stained with PTGIS antibody ABIN214200 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-PTGIS antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 1 each Anmelden zum Anzeigen 11 bis 14 Tage
$639.83
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Western Blot; Sample: Rat Prostate lysate; Primary Ab: 2µg/ml Rabbit Anti-Human PTGIS Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) Figure. Western Blot; Sample: Recombinant protein. 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$316.00
Details

Am meisten referenzierte anti-Prostaglandin I2 (Prostacyclin) Synthase Antikörper

  1. Human Polyclonal PTGIS Primary Antibody für ELISA, WB - ABIN562513 : Gurgul-Convey, Hanzelka, Lenzen: Mechanism of prostacyclin-induced potentiation of glucose-induced insulin secretion. in Endocrinology 2012 (PubMed)

Weitere Antikörper gegen Prostaglandin I2 (Prostacyclin) Synthase Interaktionspartner

Human Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. We identified an association between a PGIS variant and SAB risk that is modified by NSAIDs use during pregnancy and directly associated with increased levels of PGE metabolites. This suggests the potential use of genetic information to guide pharmaceutical intervention to prevent adverse pregnancy outcomes.

  2. In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA, 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression

  3. Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein.

  4. results indicate that PGIS expression was associated with radiotherapy efficiency

  5. Type-2 diabetes is associated with higher COX-2 expression, but lower eNOS and PGIS expression in subcutaneous arteries.

  6. In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH.

  7. These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts.

  8. High PTGIS expression is associated with colorectal cancer hepatic metastasis.

  9. The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD

  10. Overexpression of PTGIS is associated with liver metastasis in colon cancer.

  11. diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes

  12. downregulated in endometriosis tissues

  13. Review: PGI2 function depends on the different alleles of the PTGIS gene and that they may influence the risk of cardiovascular disease.

  14. PGIS overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways

  15. MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people.

  16. Association study between a novel single nucleotide polymorphism of the promoter region of the prostacyclin synthase gene and essential hypertension.

  17. NMR and circular dichroism solution structure of microsomal PGIS

  18. the fallopian tube expresses both COX isoforms and PGIS

  19. the PGIS gene has a splicing mutation in familial hypertension

  20. Cyclic mechanical stretch augmented prostacyclin synthase promoter activity, via activation of activator protein-1 site, and prostacyclin synthase mRNA and protein expression in cultured human myometrial cells

Mouse (Murine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. Prostacyclin synthase and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  2. Taken together, our in vitro and in vivo findings show that prostacyclin is secreted from neovessels formed as a result of CNS inflammation

  3. Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner.

  4. Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth.

  5. an anlysis of the transcription regulation of this gene

  6. The two major genetic loci Pgis1 and Pgis2 of murine spondylitis are homologous to chromosome regions in human genome, which control ankylosing spondylitis in human patients.

  7. CD40 ligand might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase.

  8. Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2) release but also abolished high-glucose-enhanced PGIS nitration.

  9. Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2) is required to enhance the inhibition of sympathoactivation.

  10. The results provide strong evidence that the protective effects of COX-2 within the liver are mediated through the production of PGE(2) and PGI(2), which exert anti-inflammatory functions.

  11. Endothelial PGI synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury.

  12. identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site

  13. COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease

  14. The results establish a role for the IP receptor in protecting pyramidal hippocampal neurons after this global ischemic model and suggest that IP receptor agonists could be developed to prevent delayed pyramidal neuronal cell death.

  15. PGIS/ IP transgenic animals with lung-specific PPARgamma overexpression also developed fewer lung tumors.

Zebrafish Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. crystal structures of ligand-free, inhibitor (minoxidil)-bound and substrate analog U51605-bound PGIS

Pig (Porcine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. Disturbances in prostacyclin synthase and its receptor may lead to disruption of the oviductal environment and, in turn, perturbed development of embryos and their transport to the uterus.

  2. Prostacyclin synthase is differentially expressed in the endometrium of cyclic and pregnant gilts resulting in higher PGI(2) synthesis in pregnant animals

  3. CRP stimulates superoxide production and the subsequent formation of peroxynitrite from basal released nitric oxide compromises PGI(2) synthesis.

Cow (Bovine) Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Interaktionspartner

  1. Specific nitration at tyrosine 430 is revealed by high resolution mass spectrometry as basis for redox regulation of this enzyme.

Prostaglandin I2 (Prostacyclin) Synthase (PTGIS) Antigen-Profil

Protein Überblick

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Genbezeichner und Symbole assoziert mit PTGIS

  • prostaglandin I2 synthase (PTGIS) Antikörper
  • prostaglandin I2 (prostacyclin) synthase (Ptgis) Antikörper
  • prostaglandin I2 (prostacyclin) synthase (ptgis) Antikörper
  • prostacyclin synthase (VDBG_06319) Antikörper
  • prostaglandin I2 synthase (Ptgis) Antikörper
  • Cyp8 Antikörper
  • Cyp8a1 Antikörper
  • Pgis Antikörper
  • PTGI Antikörper
  • PTGIS Antikörper
  • ptgisl Antikörper

Bezeichner auf Proteinebene für PTGIS

cytochrome P450, family 8, subfamily A, polypeptide 1 , prostacyclin synthase , prostaglandin I2 synthase , prostaglandin I2 (prostacyclin) synthase like , prostaglandin I2 (prostacyclin) synthase , cytochrome P450 8A1

GENE ID SPEZIES
5740 Homo sapiens
19223 Mus musculus
559148 Danio rerio
9535224 Verticillium alfalfae VaMs.102
458323 Pan troglodytes
703407 Macaca mulatta
100126284 Sus scrofa
100592236 Nomascus leucogenys
25527 Rattus norvegicus
282021 Bos taurus
100734621 Cavia porcellus
101116418 Ovis aries
100071412 Equus caballus
100856661 Canis lupus familiaris
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