Prostaglandin E Synthase Proteine (PTGES)

The protein encoded by PTGES is a glutathione-dependent prostaglandin E synthase. Zusätzlich bieten wir Ihnen Prostaglandin E Synthase Antikörper (62) und Prostaglandin E Synthase Kits (31) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGES 9536 O14684
PTGES 64292 Q9JM51
Ratte PTGES PTGES 59103  
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Top Prostaglandin E Synthase Proteine auf

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days

PTGES Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Prostaglandin E Synthase (PTGES) Interaktionspartnern

Human Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. study reveals that upregulation of PGES via TLR3 is critical for BM-MSCs-mediated immunosuppression by PGE2 secretion via the COX-2/PGE2 pathway.

  2. Down-regulation of mPGES-1 has been noted in the infrapatellar fat pad of osteoarthritis patients with hypercholesterolemia.

  3. we provide proof-of-principle of the benefits of targeting mPGES-1 in neuroblastoma, applicable to a wide variety of tumors. This non-toxic single drug treatment targeting infiltrating stromal cells opens up for combination treatment options with established cancer therapies.

  4. In contrast to COX-2 inhibition, inhibition of mPGES-1 reduced vasoconstriction by increasing PGI2 synthesis. Targeting mPGES-1 could provide a lower risk of cardiovascular side effects, compared with those of the COX-2 inhibitors.

  5. this paper focuses on recent studies that have demonstrated the involvement of mPGES-1 in pathological brain diseases--{REVIEW}

  6. Studied iNOS(inducible nitric oxide synthase) activation thru mPGES-1 (microsomal prostaglandin E synthase-1) signaling driven by EGFR (EGF receptor) in cancer progression models.

  7. Rs5629CC is not only independent risk factor for symptomatic carotid artery or intracranial arterial stenosis, but is also independent risk predictor for neurologic deterioration in ischemic stroke patients.

  8. COX-2 and mPGES-1-dependent synthesis of PGE2 contributes to a dedifferentiated aortic smooth muscle cell phenotype.

  9. Several studies provide evidence that the expression of mPGES1 is regulated by a number of transcriptional factors and inducible in conditions of inflammation and hypoxia.[review]

  10. The Genome Wide Area Study, using a phenotyping algorithm for asthma for data mining electronic medical records, identified four asthma susceptibility loci: 6p21.31, 9p21.2, and 10q21.3 in the European American population; and the prostaglandin synthase E gene (PTGES) at 9q34.11 in African Americans. Biologic support exists for genes at the 9p21.2 and 9q34.11 loci TEK, encoding the endothelial tyrosine in animal studies.

  11. C-myc regulates mPGES1 expression by binding to the proximal promoter. C-myc transfection in HeLa cells up-regulates mPGES1 mRNA and protein expression.

  12. COX-2 and mPGES-1 have roles in arachidonic acid regulation of inflammatory prostaglandin E2 biosynthesis

  13. The identified amino acid residues can act as target sites for the design and development of drug candidates against mPGES-1

  14. These findings support the value of a prognostic and predictive role for mPGES1.

  15. Data show that statins limit hepatic myofibroblasts proliferation via a cyclooxyegnase-2 (COX-2) and microsomal PGE synthase-1 (mPGES-1) dependent pathway.

  16. Data show that cyclooxygenase2 (COX2)overexpression induces prostaglandin E synthase (PTGES) through early growth response 1 (EGR1) in colorectal cancer cell lines.

  17. mPGES-1 is downregulated via EGR1 and has a role in caffeine inhibition on PGE2 synthesis of HBx hepatocytes

  18. results demonstrate that mPGES-1 is a target gene of defective mismatch repair in human colorectal cancer, with functional consequence

  19. Altered expression of EP2 in patients with aspirin-exacerbated respiratory disease contributes to deficient induction of IL-1RI, reducing the capacity of IL-1beta to increase COX-2 and mPGES-1 expression, which results in low PGE2 production

  20. High levels of intra tumoral mPGES-1 is associated with poor prognosis. mPGES-1 after chemotherapy is associated with improved outcomes.

Mouse (Murine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. We conclude that mPGES1 is necessary in vivo to mount optimal Treg and Th17 responses during an Ag-driven primary immune response.

  2. mPGES-1 stimulates an intercellular interaction between CD4+ T cells by upregulating the autocrine function of IL-1beta inexperimental autoimmune encephalomyelitis.

  3. mPGES-1-derived prostaglandin E2 stimulates Stat3 to promote podocyte apoptosis.

  4. Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen

  5. COX-1 and mPGES-1 are co-localized in placental syncytiotrophoblasts-level II, facing fetal-placental circulation

  6. COX-2/mPGES-1/PGE2 cascade activation mediates uric acid-induced glomerular mesangial cell proliferation.

  7. that mPGES-1 exerts a potentially protective effect against renal fibrosis and inflammation induced by unilateral ureteral obstruction in mice

  8. In line with the acetyltransferase activity of p300, H3K27 acetylation was reduced after HDACi and resulted in the formation of heterochromatin in the PTGES1 gene. In conclusion, HDAC activity maintains PTGES1 expression by recruiting p300 to its gene

  9. The findings suggest that COX-2/mPGES-1/PGE2 axis could be activated by albumin in the proximal tubular cells via a NLRP3 inflammasome-mediated mechanism and could thus contribute to proteinuria-related renal tubular cell injury.

  10. mPGES-1 overexpression prevents Fas-induced hepatocyte apoptosis and liver injury through activation of Akt .

  11. The expression of Lcn2 and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS), indicating that Lcn2 mediates LPS-induced inflammation. These findings shed light on the role of Lcn2 during decidualization.

  12. The results show that mPges-1 may be a direct downstream target gene of the P4 receptor.

  13. mPges-1 depletion modestly increased thrombogenesis in LDL-receptor knockout mice. This response was markedly further augmented by coincident deletion of the I prostanoid receptor.

  14. Data (including data from studies in knockout mice) suggest interactions of cholinergic/prostaglandin systems participate in neuroimmunomodulation; microsomal Ptges-1 is part of cholinergic anti-inflammatory response in chronic inflammatory diseases.

  15. Prostacyclin synthase and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis.

  16. Gas6, through upregulation of Ptges/PGE2, contributes to cancer-induced venous thrombosis.

  17. Vascular mPGES-1 plays a protective role in blood vessels and attenuates rupture of cerebral aneurysms.

  18. Suggest pivotal role of COX-2-mPGES-1-PGE2 axis in vascular calcification. Inhibition of COX-2 or mPGES-1 may increase the risk of calcification and subsequent adverse cardiovascular events during chronic renal failure.

  19. The present results suggest that mPGES-1 plays a significant role in lymphangiogenesis during inflammation, and represents a novel target for controlling IL.

  20. data suggests that an as yet unidentified prostaglanind E synthase but not mPGES-1 may couple with COX-2 to mediate increased renal PGE2 sythsesis in DN.

Cow (Bovine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. The objective of this study was to evaluate the mRNA expression of prostaglandin-endoperoxide synthase 2 (PTGS 2), prostaglandin F2alpha synthase (PTGFS) and prostaglandin E2 microsomal synthase 1 (mPTGES 1) in the endometrium of repeat-breeding cows with and without subclinical endometritis.

  2. Prostaglandin E synthase interacts with inducible heat shock protein 70 after heat stress in bovine primary dermal fibroblast cells.

  3. Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle.

  4. Data suggest that elevated temperatures stimulate PGE2 production in ampullary oviduct by increasing expression of PGES and HSP90AA1 (heat shock 90 kD protein 1 alpha).

  5. PGES pathway is responsible for the endometrial production of PGE(2) in the bovine endometrium during the estrous cycle

  6. activity and purification of this membrane-bound protein from the heart

Horse (Equine) Prostaglandin E Synthase (PTGES) Interaktionspartner

  1. This study showed that COX-1 and COX-2 in genital carcinomas in the horse is poor; microsomal PGES-1 is more prominently expressed.

Prostaglandin E Synthase (PTGES) Protein Überblick

Protein Überblick

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Genbezeichner und Symbole assoziert mit PTGES

  • prostaglandin E synthase (PTGES)
  • prostaglandin E synthase S homeolog (ptges.S)
  • prostaglandin E synthase (Ptges)
  • 2410099E23Rik Protein
  • D2Ertd369e Protein
  • MGC80290 Protein
  • MGST-IV Protein
  • MGST1-L1 Protein
  • MGST1L1 Protein
  • mPGES Protein
  • MPGES-1 Protein
  • Pges Protein
  • PIG12 Protein
  • PP102 Protein
  • PP1294 Protein
  • PTGES Protein
  • TP53I12 Protein

Bezeichner auf Proteinebene für PTGES

microsomal prostaglandin E synthase-1 , prostaglandin E synthase , MGST1-like 1 , glutathione S-transferase 1-like 1 , microsomal glutathione S-transferase 1-like 1 , microsomal prostaglandin E synthase 1 , p53-induced apoptosis protein 12 , p53-induced gene 12 protein , tumor protein p53 inducible protein 12

417193 Gallus gallus
654407 Sus scrofa
446534 Xenopus laevis
473071 Pan troglodytes
9536 Homo sapiens
64292 Mus musculus
59103 Rattus norvegicus
100733230 Cavia porcellus
282019 Bos taurus
480698 Canis lupus familiaris
100034143 Equus caballus
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