Prostaglandin E Receptor 4 (Subtype EP4) Proteine (PTGER4)

The protein encoded by PTGER4 is a member of the G-protein coupled receptor family. Zusätzlich bieten wir Ihnen PTGER4 Antikörper (93) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGER4 5734 P35408
PTGER4 19219 P32240
Ratte PTGER4 PTGER4 84023 P43114
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Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 bis 55 Tage
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 bis 55 Tage
Wheat germ Human GST tag 2 μg 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Wheat germ Human Unkonjugiert   10 μg 11 bis 12 Tage

PTGER4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,

Weitere Proteine zu Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartnern

Zebrafish Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde intraflagellar transport, thereby promoting ciliogenesis.

  2. Ep4a, a PGE2 receptor isoform of EP4, is involved in lymphoid precursor development in zebrafish.

Human Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk-conferring gastric cancer patho-mechanisms.

  2. COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases

  3. butyrate uptake reduces expressions of prostanoid EP4 receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells

  4. SHOX2 and PTGER4 methylation detection in blood plasma has certain value in the early diagnosis of lung cancer

  5. Data indicates that PGE2 suppression of TNF-alpha by human monocytic cells occurs via EP2R and EP4R expression. However EP4Rs also control their own expression and that of EP2 whereas the EP2R does not affect EP4R expression. This implies that EP4 receptors have an important master role in controlling inflammatory responses.

  6. discovery of recurrent PTGER4 amplification implies a potential of exploring targeting therapy to the prostaglandin synthesis pathways in a subset of these tumors

  7. High EP4 expression is associated with chemoresistant breast carcinoma.

  8. Study demonstrated that the expression of EP4 receptors was up-regulated by c-Myc by binding to Sp-1 under low cellular density conditions but was down-regulated under high cellular density conditions via the increase in the expression levels of HIF-1alpha protein, which may pull out c-Myc and Sp-1 from DNA-binding.

  9. results indicate that PGE2 inhibits hCAP18/LL-37 expression, especially VD3-induced cathelicidin and autophagy, which may reduce host defense against Mtb. Accordingly, antagonists of EP4 may constitute a novel adjunctive therapy in Mtb infection.

  10. Case Report: elevated EP4 expression in pulmonary hypertension patient with dissecting pulmonary aneurysm.

  11. Collectively, these results indicate that COX-1/PGE2/EP4 upregulates the beta-arr1 mediated Akt signaling pathway to provide mucosal protection in colitis.

  12. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells.

  13. High PTGER4 methylation is associated with Lung cancer.

  14. in breast cancer cells overexpression of S1P3 and its activation by S1P has pro-inflammatory and pro-metastatic potential by inducing COX-2 expression and PGE2 signaling via EP2 and EP4.

  15. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis.

  16. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM, as well as the invasion of breast cancer cells in in vitro models.

  17. EP4 expression can promote the development of resistance to aromatase inhibitor therapy for breast cancer

  18. Findings suggest SUMO-1 protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers.

  19. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR interactive signaling.

  20. The cross-talk between SP1 and p65, and the positive feedback regulatory loop of PI3-K/Akt signaling by EP4 contribute to the overall responses of solamargine in this process

Mouse (Murine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. PGE2 regulates metabolism of hepatocytes mainly through EP4 receptor.

  2. CD4(+) T effector cells either deficient in prostaglandin E synthase (mPGES-1) or the prostaglandin E2 alpha (PGE2) prostaglandin EP4 receptor (receptor EP4) are less colitogenic.

  3. Removal of the IP receptors unmasks a protective role of mPGES-1-derived PGE2 in limiting injury-induced vascular hyperplasia. EP4, in the endothelial compartment, is essential to promote reendothelialization and restrain neointimal formation after injury.

  4. Overexpression of EP4 improves cardiac function post myocardial infarction.

  5. Study reports that mPGES-1 protects against acute myocardial ischemia-reperfusion (I/R) injury in mice and this is attributed to its critical role in preserving microcirculation and limiting inflammation in I/R. The cardioprotective effect of mPGES-1 is partially mediated through PGE2 action on the endothelial PGE receptor-4.

  6. Our data suggest that deletion of EP4 in S100a4-lineage cells inhibits range of motion-limiting scar tissue without further compromising mechanical properties.

  7. EP4 enhancement aggravated imbalanced mesangial cell proliferation stimulated by TGFbeta1 and GS of mice treated with 5/6 nephrectomy through the Smad and mitogenactivated protein kinase pathways.

  8. EP4 is a novel regulator of bile acid synthesis, and its activation protects against hypercholesterolemia.

  9. Paricalcitol also attenuated the infiltration of inflammatory cells and production of proinflammatory cytokines after IR injury. EP4 antagonist abolished these antioxidant, anti-inflammatory, and antiapoptotic effects. The EP4 plays a pivotal role in the protective effects of paricalcitol in renal IR injury.

  10. These results demonstrate a novel role for prostaglandin receptor EP4 in the mediation of barrier-enhancing and anti-inflammatory effects caused by oxidized phospholipids.

  11. The deletion of EP4 increases mitochondrial biogenesis and oxidative capacity in WAT, and fat mass loss ensues in mice.

  12. Myeloid cell Ptger4 modulates interleukin production but not atherogenesis in type I diabetic mice.

  13. These data suggest that vascular EP4 receptors buffer the actions of AngII on renal hemodynamics and oxidative injury.

  14. the roles of prostaglandin E2 (PGE2) receptor (EP) signaling in enhancement of lymphangiogenesis in wound healing processes

  15. these studies have demonstrated an important but unexpected role for macrophage COX-2/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells.

  16. data demonstrate that endogenous PGE2, EP2 receptors, and EPAC are prerequisites for maximal LPS-induced IL-33 expression and that exogenous PGE2 can amplify IL-33 production via EP2 and EP4 receptors.

  17. The data presented highlight a key role for EP2 and EP4 receptors in microvascular leak induced by PGE2.

  18. It mediates neuritogenesis in sensory neuron.

  19. These results suggest that Il23a expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-kappaB pathways and CREB activated by CD40 stimulation.

  20. autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4(+) T-cell activation.

Cow (Bovine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Data suggest that lysophosphatidic acid (LPA) up-regulates expression of SLCO2A1 (prostaglandin [PG] transporter), PTGER2/PTGER4 (PG receptors EP2/EP4), and mPGES1/cPGES (microsomal/cytosolic PG E synthases) in luteal cells.

  2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor).

  3. The PGE2-mediated down-regulation of CD25 expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 expression on these cells.

  4. EP4 is undetectable in endometrium and myometrium during the estrous cycle

  5. Quantitative RT-PCR revealed significant higher expression of EP2 and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct

PTGER4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Genbezeichner und Symbole assoziert mit PTGER4

  • prostaglandin E receptor 4 (PTGER4)
  • prostaglandin E receptor 4 (subtype EP4) (PTGER4)
  • prostaglandin E receptor 4 (subtype EP4) a (ptger4a)
  • prostaglandin E receptor 4 (ptger4)
  • prostaglandin E receptor 4 subtype EP4 (ptger4)
  • prostaglandin E receptor 4 (subtype EP4) (Ptger4)
  • prostaglandin E receptor 4 (Ptger4)
  • ep4 Protein
  • EP4R Protein
  • PGE2R-EP4 Protein
  • Ptger Protein
  • PTGER4 Protein
  • ptger4l Protein
  • Ptgerep4 Protein

Bezeichner auf Proteinebene für PTGER4

prostaglandin E receptor 4, subtype EP4 , prostaglandin E2 receptor EP4 subtype , prostaglandin E2 receptor subtype 4 , prostaglandin E receptor 4 (subtype EP4) , ep4 , ep4a , prostaglandin E receptor 4 , prostaglandin E receptor 4 subtype EP4 , PGE receptor EP4 subtype , PGE receptor, EP4 subtype , PGE2 receptor EP4 subtype , prostanoid EP4 receptor , prostaglandin E receptor 4 (EP4 subtype) , prostaglandin E receptor EP4 subtype , prostaglandin E2 receptor type 4 , PGE receptor, subtype EP4 , prostaglandin receptor EP4 subtype , prostaglandin E2 subtype EP4 receptor

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443222 Ovis aries
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695220 Macaca mulatta
100145708 Xenopus (Silurana) tropicalis
100169968 Felis catus
100510774 Anolis carolinensis
5734 Homo sapiens
19219 Mus musculus
84023 Rattus norvegicus
403589 Canis lupus familiaris
282331 Bos taurus
100009081 Oryctolagus cuniculus
450195 Pan troglodytes
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