Prostaglandin E Receptor 4 (Subtype EP4) Proteine (PTGER4)

The protein encoded by PTGER4 is a member of the G-protein coupled receptor family. Zusätzlich bieten wir Ihnen PTGER4 Antikörper (89) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTGER4 5734 P35408
PTGER4 19219 P32240
Ratte PTGER4 PTGER4 84023 P43114
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Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$225.40
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$814.00
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Wheat germ Human Unkonjugiert   10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$654.29
Details

PTGER4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,
,

Weitere Proteine zu Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartnern

Zebrafish Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Lkt/ABCC4 (zeige ABCC4 Proteine)-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor (zeige GPBAR1 Proteine), EP4, to upregulate cAMP synthesis and increase anterograde intraflagellar transport, thereby promoting ciliogenesis.

  2. Ep4a, a PGE2 receptor isoform of EP4, is involved in lymphoid precursor development in zebrafish.

Human Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Case Report: elevated EP4 expression in pulmonary hypertension patient with dissecting pulmonary aneurysm.

  2. Collectively, these results indicate that COX-1/PGE2/EP4 upregulates the beta-arr1 (zeige ARRB1 Proteine) mediated Akt (zeige AKT1 Proteine) signaling pathway to provide mucosal protection in colitis.

  3. Reprogramming of mammary epithelial cells can result from EP4 -mediated stem cell property transfer by extracellular vesicles/exosomes containing caveolae-associated proteins, between mammary basal and luminal epithelial cells.

  4. High PTGER4 methylation is associated with Lung cancer.

  5. in breast cancer cells overexpression of S1P3 (zeige S1PR3 Proteine) and its activation by S1P (zeige MBTPS1 Proteine) has pro-inflammatory and pro-metastatic potential by inducing COX-2 expression and PGE2 signaling via EP2 (zeige SPAG11B Proteine) and EP4.

  6. These results indicate that the blockage of PGE2-EP4 signaling prevents the bone destruction required for prostate cancer metastases, and that this is, in part due to the abrogation of bone cell responses. The study provides further evidence that an EP4 antagonist is a candidate for the treatment of prostate cancer in the blockade of bone metastasis.

  7. The results show that stimulation with the selective EP4 agonist CAY10598 or PGE2 promotes invadopodia-mediated degradation of the ECM (zeige MMRN1 Proteine), as well as the invasion of breast cancer cells in in vitro models.

  8. EP4 expression can promote the development of resistance to aromatase (zeige CYP19A1 Proteine) inhibitor therapy for breast cancer

  9. Findings suggest SUMO-1 (zeige SUMO1 Proteine) protein and PGE2 receptor subtype 4 (EP4) as two potential targets for new therapeutic or prevention strategies for endometrial cancers.

  10. GW627368X therefore effectively inhibits cervical cancer survival, motility, proliferation and angiogenesis by blocking EP4/EGFR (zeige EGFR Proteine) interactive signaling.

Mouse (Murine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Paricalcitol also attenuated the infiltration of inflammatory cells and production of proinflammatory cytokines after IR injury. EP4 antagonist abolished these antioxidant, anti-inflammatory, and antiapoptotic effects. The EP4 plays a pivotal role in the protective effects of paricalcitol in renal IR injury.

  2. These results demonstrate a novel role for prostaglandin receptor EP4 in the mediation of barrier-enhancing and anti-inflammatory effects caused by oxidized phospholipids.

  3. The deletion of EP4 increases mitochondrial biogenesis and oxidative capacity in WAT, and fat mass loss ensues in mice.

  4. Myeloid cell Ptger4 modulates interleukin production but not atherogenesis in type I diabetic mice.

  5. These data suggest that vascular EP4 receptors buffer the actions of AngII on renal hemodynamics and oxidative injury.

  6. these studies have demonstrated an important but unexpected role for macrophage COX-2/prostaglandin E2/PGE2 receptor subtype 4 signaling to lessen progression of diabetic kidney disease, unlike the pathogenic effects of increased COX-2 expression in intrinsic renal cells.

  7. data demonstrate that endogenous PGE2, EP2 (zeige SPAG11A Proteine) receptors, and EPAC (zeige RAPGEF3 Proteine) are prerequisites for maximal LPS (zeige TLR4 Proteine)-induced IL-33 (zeige IL33 Proteine) expression and that exogenous PGE2 can amplify IL-33 (zeige IL33 Proteine) production via EP2 (zeige SPAG11A Proteine) and EP4 receptors.

  8. The data presented highlight a key role for EP2 (zeige SPAG11A Proteine) and EP4 receptors in microvascular leak induced by PGE2.

  9. These results suggest that Il23a (zeige IL23A Proteine) expression in DCs is synergistically triggered by the PG E2-EP4-cAMP-PKA pathway and canonical/non-canonical NF-kappaB (zeige NFKB1 Proteine) pathways and CREB (zeige CREB1 Proteine) activated by CD40 (zeige CD40 Proteine) stimulation.

  10. autocrine prostaglandin E2 signaling through EP receptors is essential for optimal CD4 (zeige CD4 Proteine)(+) T-cell activation.

Cow (Bovine) Prostaglandin E Receptor 4 (Subtype EP4) (PTGER4) Interaktionspartner

  1. Data suggest that lysophosphatidic acid (LPA (zeige PLG Proteine)) up-regulates expression of SLCO2A1 (zeige SLCO2A1 Proteine) (prostaglandin [PG] transporter), PTGER2 (zeige PTGER2 Proteine)/PTGER4 (PG receptors EP2 (zeige SPAG11A Proteine)/EP4), and mPGES1 (zeige PTGES Proteine)/cPGES (zeige PTGES3 Proteine) (microsomal/cytosolic PG E synthases) in luteal cells.

  2. Data suggest that estradiol up-regulates mRNA and protein expression of 3 prostanoid receptors in oviduct smooth muscle: EP2/PTGER2 (zeige PTGER2 Proteine) (prostaglandin E receptor 2); EP4/PTGER4 (prostaglandin E receptor 4); and FP/PTGFR (prostaglandin F2alpha receptor (zeige PTGFR Proteine)).

  3. The PGE2-mediated down-regulation of CD25 (zeige IL2RA Proteine) expression on T cells is mediated via the EP4 receptor, although selective activation of the EP2 receptor up-regulates the CD25 (zeige IL2RA Proteine) expression on these cells.

  4. EP4 is undetectable in endometrium and myometrium during the estrous cycle

  5. Quantitative RT-PCR revealed significant higher expression of EP2 (zeige SPAG11A Proteine) and EP4 in the pre-ovulatory phase compared with the luteal phase in the bovine oviduct

PTGER4 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Genbezeichner und Symbole assoziert mit PTGER4

  • prostaglandin E receptor 4 (PTGER4)
  • prostaglandin E receptor 4 (subtype EP4) (PTGER4)
  • prostaglandin E receptor 4 (subtype EP4) a (ptger4a)
  • prostaglandin E receptor 4 (ptger4)
  • prostaglandin E receptor 4 subtype EP4 (ptger4)
  • prostaglandin E receptor 4 (subtype EP4) (Ptger4)
  • prostaglandin E receptor 4 (Ptger4)
  • ep4 Protein
  • EP4R Protein
  • PGE2R-EP4 Protein
  • Ptger Protein
  • PTGER4 Protein
  • ptger4l Protein
  • Ptgerep4 Protein

Bezeichner auf Proteinebene für PTGER4

prostaglandin E receptor 4, subtype EP4 , prostaglandin E2 receptor EP4 subtype , prostaglandin E2 receptor subtype 4 , prostaglandin E receptor 4 (subtype EP4) , ep4 , ep4a , prostaglandin E receptor 4 , prostaglandin E receptor 4 subtype EP4 , PGE receptor EP4 subtype , PGE receptor, EP4 subtype , PGE2 receptor EP4 subtype , prostanoid EP4 receptor , prostaglandin E receptor 4 (EP4 subtype) , prostaglandin E receptor EP4 subtype , prostaglandin E2 receptor type 4 , PGE receptor, subtype EP4 , prostaglandin receptor EP4 subtype , prostaglandin E2 subtype EP4 receptor

GENE ID SPEZIES
427183 Gallus gallus
443222 Ovis aries
562469 Danio rerio
695220 Macaca mulatta
100145708 Xenopus (Silurana) tropicalis
100169968 Felis catus
100510774 Anolis carolinensis
5734 Homo sapiens
19219 Mus musculus
84023 Rattus norvegicus
403589 Canis lupus familiaris
282331 Bos taurus
100009081 Oryctolagus cuniculus
450195 Pan troglodytes
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