Prolyl Endopeptidase Like Protein Proteine (PREPL)

The protein encoded by PREPL belongs to the prolyl oligopeptidase subfamily of serine peptidases.

alle Proteine anzeigen Gen GeneID UniProt
Human PREPL PREPL 9581 Q4J6C6
Maus PREPL PREPL 213760 Q8C167
Ratte PREPL PREPL 298771 Q5HZA6
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
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Weitere Proteine zu Prolyl Endopeptidase Like Protein (PREPL) Interaktionspartnern

Human Prolyl Endopeptidase Like Protein (PREPL) Interaktionspartner

  1. Deletion of PREPL is associated with Hypotonia-cystinuria syndrome.

  2. Two novel deletions encompassing the SLC3A1 (zeige SLC3A1 Proteine) and PREPL genes have been identified in unrelated hypotonia-cystinuria syndrome patients.

  3. A 638-residue variant of PREPL, PREPL A, was identifiied, expressed in Escherichia coli and purified; its secondary structure was similar to that of oligopeptidase B.

  4. Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome.

  5. Deletion of the gene results in hypotonia at birth, failure to thrive and growth hormone deficiency

  6. a deletion of PREPL causes atypical hypotonia-cystinuria syndrome

  7. Two key transcription factors, NRF-2 (zeige GABPA Proteine) and YY-1 (zeige YY1 Proteine), were further identified to coordinately participate in driving gene expressions of PREPL-C2ORF34 (zeige CAMKMT Proteine) genes pairin an additive manner.

Mouse (Murine) Prolyl Endopeptidase Like Protein (PREPL) Interaktionspartner

  1. The data demonstrate PREPL as an AP-1 (zeige JUN Proteine) effector that takes part in the regulation of AP-1 (zeige JUN Proteine) membrane binding. PREPL is highly expressed in brain and at lower levels in muscle and kidney.

Prolyl Endopeptidase Like Protein (PREPL) Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit PREPL

  • prolyl endopeptidase-like (PREPL)
  • prolyl endopeptidase-like (Prepl)
  • prolyl endopeptidase-like (prepl)
  • 2810457N15Rik Protein
  • 9530014L06Rik Protein
  • D030028O16Rik Protein
  • mKIAA0436 Protein
  • RGD1310143 Protein

Bezeichner auf Proteinebene für PREPL

putative prolyl oligopeptidase , prolylendopeptidase-like

GENE ID SPEZIES
9581 Homo sapiens
213760 Mus musculus
298771 Rattus norvegicus
421405 Gallus gallus
100171865 Pongo abelii
100381109 Xenopus laevis
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