Prolyl 4-Hydroxylase, alpha Polypeptide I Proteine (P4HA1)

P4HA1 encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. Zusätzlich bieten wir Ihnen P4HA1 Antikörper (73) und P4HA1 Kits (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
P4HA1 18451 Q60715
P4HA1 5033 P13674
P4HA1 64475 P54001
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Top P4HA1 Proteine auf antikoerper-online.de

Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,470.50
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Escherichia coli (E. coli) Ratte S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details

P4HA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
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Rat (Rattus) ,
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Weitere Proteine zu Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) Interaktionspartnern

Mouse (Murine) Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) Interaktionspartner

  1. Overexpression of P4Ha1 increased atherosclerotic plaque size.

  2. IL-6 (zeige IL6 Proteine) destabilizes atherosclerotic plaques by downregulating P4Halpha1 via an RAF-MEK1/2-ERK1/2 MAPK and c-Jun pathway.

  3. C-P4H alpha(I) and alpha(II (zeige GSTA3 Proteine)) mRNA levels were increased in hypoxic mouse chondrocytes in a manner dependent on HIF-1a (zeige HIF1A Proteine).

Human Prolyl 4-Hydroxylase, alpha Polypeptide I (P4HA1) Interaktionspartner

  1. High expression of P4HA1 was correlated with the malignancy of gliomas and could serve as a prognostic indicator for patients with high-grade gliomas

  2. Our study indicates that P4HA1 plays a pivotal role in the process of GSC (zeige GSC Proteine)-EC transdifferentiation and the structural formation of vascular BMs.

  3. we report compound heterozygous frameshift and splice site mutations in P4HA1 that impair but not abolish C-P4H alpha(I) activity. The maternal P4HA1 exon 12 splice donor site mutation causes an internally deleted C-P4H alpha(I) predicted to completely lack catalytic activity. two nucleic acid insertion in exon 9 results in a premature stop in the exon 9 P4HA1 splice form.

  4. Findings suggest that the catalytic domain of collagen prolyl 4-hydroxylases (CP4Hs) recognizes the cis (zeige CISH Proteine) conformation of the prolyl peptide bond.

  5. Thus, we conclude that miR (zeige MLXIP Proteine)-30e suppresses proliferation of hepatoma cells through targeting P4HA1 mRNA.

  6. Studies indicate P4HA1 copy number gain in a subset of metastatic prostate tumors and its expression is also regulated by microRNA-124.

  7. Overexpression of miR (zeige MLXIP Proteine)-122 markedly attenuated the expression of P4HA1 via targeting a binding site located at 3'-UTR of P4HA1 mRNA

  8. Hypoxia-inducible factor 1 (HIF-1 (zeige HIF1A Proteine)) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2 (zeige P4HA2 Proteine), and PLOD2 (zeige PLOD2 Proteine) expression in fibroblasts.

  9. IL-6 (zeige IL6 Proteine) significantly downregulated P4Halpha1 expression in aortic smooth muscle cells

  10. analysis of the 2-His-1-Asp (zeige ASIP Proteine) active-site motif in prolyl 4-hydroxylase

P4HA1 Protein Überblick

Protein Überblick

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.

Genbezeichner und Symbole assoziert mit P4HA1

  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ000975)
  • prolyl 4-hydroxylase subunit alpha-1 (CpipJ_CPIJ017131)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03346)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_03347)
  • prolyl 4-hydroxylase subunit alpha-1 (Tsp_15957)
  • prolyl 4-hydroxylase subunit alpha 1 (P4HA1)
  • procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide (P4ha1)
  • prolyl 4-hydroxylase subunit alpha 1 (P4ha1)
  • AL022634 Protein
  • P4ha Protein
  • PHalphaI Protein

Bezeichner auf Proteinebene für P4HA1

prolyl 4-hydroxylase subunit alpha-1 , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I , prolyl 4-hydroxylase alpha subunit , prolyl 4-hydroxylase, alpha I subunit , 4-PH alpha-1 , procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1 , C-P4Halpha(I) , collagen prolyl 4-hydroxylase alpha(I) , procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide

GENE ID SPEZIES
6031971 Culex quinquefasciatus
6051272 Culex quinquefasciatus
10909085 Trichinella spiralis
10909086 Trichinella spiralis
10909998 Trichinella spiralis
100037299 Sus scrofa
450891 Pan troglodytes
18451 Mus musculus
5033 Homo sapiens
479242 Canis lupus familiaris
64475 Rattus norvegicus
518288 Bos taurus
423704 Gallus gallus
100172658 Pongo abelii
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