Pregnancy-Associated Plasma Protein A, Pappalysin 1 Proteine (PAPPA)

PAPPA encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Zusätzlich bieten wir Ihnen PAPPA Antikörper (447) und PAPPA Kits (61) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PAPPA 18491 Q8R4K8
Ratte PAPPA PAPPA 313262  
PAPPA 5069 Q13219
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Showing 10 out of 23 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$618.00
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$685.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 15 bis 18 Tage
$695.00
Details
Escherichia coli (E. coli) Human His tag   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$5,292.31
Details
Human Human Unkonjugiert   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
$312.43
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details

PAPPA Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,
,
Human , , , ,
, ,

Weitere Proteine zu Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaktionspartnern

Mouse (Murine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaktionspartner

  1. Inducible knockdown of PAPP-A gene expression in adult female mice extends life span.

  2. Intrinsic mitochondrial oxidative capacity was significantly increased in skeletal muscle of aged PAPP-A KO compared to WT mice. Moreover, 18-month-old PAPP-A KO mice exhibited significantly enhanced endurance running on a treadmill. Thus, PAPP-A deficiency in mice is associated with indices of healthy skeletal muscle function with age.

  3. Snell, GHKRO, and PAPPA-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (zeige MGMT Proteine)) and N-myc downstream-regulated gene 1 (NDRG1 (zeige NDRG1 Proteine)).

  4. STC2 (zeige STC2 Proteine) is involved in regulating PAPP-A activity during the development of atherosclerosis

  5. Study demonstrates proof-of-principle and provides feasibility for a novel therapeutic strategy to inhibit atherosclerotic plaque burden by selective targeting of PAPP-A.

  6. stimulation of PAPP-A expression by intermittent PTH (zeige PTH Proteine) treatment contributes to PTH (zeige PTH Proteine) bone anabolism in mice

  7. PAPP-A affects fascicle structure, thereby affecting tendon phenotype.

  8. PAPP-A has a role in development of advanced plaque with necrotic cores and buried fibrous caps (zeige CAPS Proteine) in the brachiocephalic artery

  9. these data indicate preferential impact of PAPP-A deficiency on visceral fat in the mouse that is associated with enhanced insulin receptor (zeige INSR Proteine) signaling

  10. Studies show a conditional PAPP-A knockout (KO) model for efficacy of tamoxifen-induced floxed PAPP-A excision in various tissues and indicate a significant reduction of neointimal formation after unilateral carotid artery ligation.

Human Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaktionspartner

  1. Studied the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease.

  2. PAPP-A and ProMBP are associated with increased risk of death in heart failure patients.

  3. PAPP-A C/C genotypes were more frequent among mothers with gestational diabetes than in control.

  4. Elevated PAPP-A compared to other risk factors was a stronger predictor for future CV events 2 years post ACS in patients with type 2 diabetes mellitus.

  5. PAPP-A, like CCS (zeige CCS Proteine) and CIMT, is a parameter that can be used to detect subclinical atherosclerosis.

  6. Results suggest that links between PAPP-A concentrations in early pregnancy and subsequent glucose concentrations and blood pressures may be mediated by changes in insulin (zeige INS Proteine) sensitivity (and secretion).

  7. Collectively, these results identify PAPP-A as a pregnancy-dependent oncogene (zeige RAB1A Proteine) while also showing that extended lactation is protective against PAPP-A-mediated carcinogenesis.

  8. Lower PlGF (zeige PGF Proteine) and higher PAPP-A and free beta-hCG (zeige CGA Proteine) levels were found in the fetal circulation of near-term severe preeclamptic pregnancies

  9. PAPP-A 1224 SNP has a significant effect on the level and activity of PAPP-A in human follicles, suggesting that the follicular fluid level of bioactive insulin (zeige INS Proteine)-like growth factor depends on the genotype.

  10. This study demonstrated no association between PAPP-A gene rs7020782 polymorphism and Preeclampsia (PE) and intrauterine growth restriction.

Cow (Bovine) Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) Interaktionspartner

  1. study determined IGFR1 (zeige IGF1R Proteine) and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD (zeige SNRPB Proteine)) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 (zeige IGF1R Proteine) expression and PAPP-A secretion as a modulator of IGF1 (zeige IGF1 Proteine) in cattle with COD (zeige SNRPB Proteine)

  2. in preovulatory follicles, PAPP-A is responsible for IGF-dependent IGFBP-2 degradation

  3. concluded that changes in granulosa cell PAPP-A mRNA levels do not occur during final preovulatory follicular development in cattle

PAPPA Protein Überblick

Protein Überblick

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses.

Genbezeichner und Symbole assoziert mit PAPPA

  • pappalysin 1 (PAPPA)
  • pregnancy-associated plasma protein A (Pappa)
  • pappalysin 1 (Pappa1)
  • pappalysin 1 (Pappa)
  • 8430414N03Rik Protein
  • ASBABP2 Protein
  • DIPLA1 Protein
  • IGFBP-4ase Protein
  • PAG1 Protein
  • PAPA Protein
  • PAPP-A Protein
  • Pappa Protein
  • PAPPA1 Protein

Bezeichner auf Proteinebene für PAPPA

IGF-dependent IGFBP-4 protease , insulin-like growth factor-dependent IGF-binding protein 4 protease , pappalysin-1 , aspecific BCL2 ARE-binding protein 2 , differentially placenta 1 expressed protein , insulin-like growth factor-dependent IGF binding protein-4 protease , pregnacy-associated plasma protein A , PAPPA-like protein , pregnancy-associated plasma protein A-like protein , cleaves insulin-like binding protein-4 (IGFBP-4) , metalloprotease

GENE ID SPEZIES
100033920 Equus caballus
18491 Mus musculus
313262 Rattus norvegicus
5069 Homo sapiens
481692 Canis lupus familiaris
282647 Bos taurus
100734958 Cavia porcellus
417245 Gallus gallus
397219 Sus scrofa
443157 Ovis aries
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