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The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Zusätzlich bieten wir Ihnen KCNN4 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal KCNN4 Primary Antibody für WB - ABIN948055
Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? in British journal of pharmacology 2014
Human Polyclonal KCNN4 Primary Antibody für IF (p), IHC (p) - ABIN719786
Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. in PLoS ONE 2016
Human Polyclonal KCNN4 Primary Antibody für IHC, IHC (p) - ABIN4328499
Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. in PLoS ONE 2015
Blockade of K(Ca)3.1 by delivery of TRAM (zeige TRAM1 Antikörper)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.
this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.
Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.
KCa3.1 channels are important modulators in hepatocellular homeostasis.
Tumor suppressor miR (zeige MLXIP Antikörper)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.
We identified a two-gene signature including KCNN4 and S100A14 (zeige S100A14 Antikörper) which was related to recurrence in optimally debulked serous ovarian carcinoma patients
Human arrhythmogenic calmodulin mutations impede the activation of SK2 (zeige KCNN2 Antikörper) channels in human embryonic kidney 293 cells.
This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.
Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (zeige TRPC1 Antikörper) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.
Higher epithelial KCNN4 expression was closely correlated with advanced TNM (zeige ODZ1 Antikörper) stages and predicted a poor prognosis in patients with pancreatic ductal adenocarcinoma.
Here, the authors demonstrate that phosphorylation of His358 activates KCa3.1 by antagonizing copper-mediated inhibition of the channel.
Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.
Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (zeige GJA4 Antikörper) and IK1 expression may contribute. nNOS (zeige NOS1 Antikörper) or iNOS (zeige NOS2 Antikörper) did not upregulate to compensate for decreased eNOS (zeige NOS3 Antikörper), and they had little involvement in vasomotor function.
The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.
KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.
KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (zeige TICAM2 Antikörper)-34.
SK4 activity is crucial for cell cycle control.
Following differentiation with LPS (zeige TLR4 Antikörper) or a combination of LPS (zeige TLR4 Antikörper) and IFN-gamma (zeige IFNG Antikörper) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (zeige CSN3 Antikörper) 3.1 and Kir (zeige GEM Antikörper) currents, while microglia differentiated with IL-4 (zeige IL4 Antikörper) exhibited large Kir (zeige GEM Antikörper) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (zeige CSN3 Antikörper) 3.1 currents were generally low
Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.
Dynamic coupling between TRPV4 (zeige TRPV4 Antikörper) and Ca(2 (zeige CA2 Antikörper)+)-activated SK1 (zeige SPHK1 Antikörper)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (zeige KCNMA1 Antikörper) in kidney collecting duct cells.
Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.
enhanced KCa (zeige CSN3 Antikörper) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.
intermediate conductance calcium-activated potassium channel protein 4
, intermediate-conductance calcium-activated potassium channel
, intermediate conductance calcium-activated potassium channel protein 1
, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
, intermediate conductance calcium-activated potassium channel protein 4-like
, SKCa 4
, putative Gardos channel
, putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel
, intermediate conductance K channel
, intermediate-conductance Ca-activated K channel
, potassium intermediate-small conductance calcium-activated channel subfamily N member 4