anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Antikörper

The protein encoded by KCNN4 is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Zusätzlich bieten wir Ihnen KCNN4 Proteine (3) und und viele weitere Produktgruppen zu diesem Protein an.

Gen	GeneID	UniProt
KCNN4	3783	O15554
KCNN4	65206
KCNN4	16534	O89109

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Top anti-KCNN4 Antikörper auf antikoerper-online.de

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Katalog Nr.	Reaktivität	Wirt	Konjugat	Applikation	Menge	Anbieter	Lieferzeit	Preis	Details
ABIN2776147	Rind (Kuh)	Kaninchen	Unkonjugiert	WB	100 μL	Anmelden zum Anzeigen	2 bis 3 Tage	$289.00	Details
ABIN4328499	Human	Kaninchen	Unkonjugiert	IHC, IHC (p)	0.1 mL	Anmelden zum Anzeigen	10 bis 13 Tage	$491.63	Details
ABIN1873386	Human	Kaninchen	Unkonjugiert	IF, IHC, WB	100 μL	Anmelden zum Anzeigen	16 Days	$334.02	Details
ABIN609700	Rind (Kuh)	Ziege	Unkonjugiert	IHC, IHC (p)	50 μg	Anmelden zum Anzeigen	7 bis 9 Tage	$484.00	Details
ABIN1048993	Fledermaus	Kaninchen	Unkonjugiert	IHC, IHC (p)	50 μg	Anmelden zum Anzeigen	7 bis 9 Tage	$484.00	Details
ABIN1048992	Rind (Kuh)	Kaninchen	Unkonjugiert	IHC, IHC (p)	50 μg	Anmelden zum Anzeigen	7 bis 9 Tage	$484.00	Details
ABIN324375	Human	Kaninchen	Unkonjugiert	WB	50 μg	Anmelden zum Anzeigen	7 bis 9 Tage	$551.83	Details
ABIN4886646	Human	Kaninchen	Unkonjugiert	IHC (p), WB	100 μg	Anmelden zum Anzeigen	4 bis 6 Tage	$240.00	Details
ABIN3043233	Human	Kaninchen	Unkonjugiert	WB	100 μg	Anmelden zum Anzeigen	4 bis 6 Tage	$240.00	Details
ABIN1107942	Human	Kaninchen	Unkonjugiert	WB	0.1 mg	Anmelden zum Anzeigen	6 bis 8 Tage	$379.50	Details

KCNN4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute	Applikationen	Wirt	Klonalität	Konjugat
Human	, , , ,	, ,	,	, , , , , , , , , , , , , , ,
Rat (Rattus)	, , , ,	, ,	,	, , , , , , , , , , , , , , ,
Mouse (Murine)	, , ,	, ,	,	, , , , , , , , , , , , ,

Weitere Produktkategorien zu KCNN4 Antikörper

Am meisten referenzierte anti-KCNN4 Antikörper

Human Polyclonal KCNN4 Primary Antibody für WB - ABIN948055 : Wong, Roberts, Randall: Sex differences in endothelial function in porcine coronary arteries: a role for H2O2 and gap junctions? in British journal of pharmacology 2014 (PubMed)
Human Polyclonal KCNN4 Primary Antibody für IF (p), IHC (p) - ABIN719786 : Zhang, Yang, Yin, Yi, Shen, Zhao, Zhu, Liu: Inhibition of SK4 Potassium Channels Suppresses Cell Proliferation, Migration and the Epithelial-Mesenchymal Transition in Triple-Negative Breast Cancer Cells. in PLoS ONE 2016 (PubMed)
Human Polyclonal KCNN4 Primary Antibody für IHC, IHC (p) - ABIN4328499 : Rabjerg, Oliván-Viguera, Hansen, Jensen, Sevelsted-Møller, Walter, Jensen, Marcussen, Köhler: High expression of KCa3.1 in patients with clear cell renal carcinoma predicts high metastatic risk and poor survival. in PLoS ONE 2015 (PubMed)

Weitere Antikörper gegen KCNN4 Interaktionspartner

Pig (Porcine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaktionspartner

Blockade of K(Ca)3.1 by delivery of TRAM (zeige TRAM1 Antikörper)-34 via balloon catheter prevented smooth muscle phenotypic modulation and limited subsequent restenosis in a swine model.

Human Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaktionspartner

this study reports cryo-electron microscopy (cryo-EM) structures of a human SK4-CaM channel complex in closed and activated states at 3.4- and 3.5-angstrom resolution, respectively.
Expression of intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1) mRNA and protein was detected in all three layers of the human cornea.
KCa3.1 channels are important modulators in hepatocellular homeostasis.
Tumor suppressor miR (zeige MLXIP Antikörper)-497-5p down-regulates KCa3.1 expression and contributes to the inhibition of angiosarcoma malignancy development.
We identified a two-gene signature including KCNN4 and S100A14 (zeige S100A14 Antikörper) which was related to recurrence in optimally debulked serous ovarian carcinoma patients
Human arrhythmogenic calmodulin mutations impede the activation of SK2 (zeige KCNN2 Antikörper) channels in human embryonic kidney 293 cells.
This study found a very substantial functional expression of KCa3.1 channels in microglia from adult epilepsy patients.
Data show that RNAi-mediated knockdown of KCa3.1 and/or TRPC1 (zeige TRPC1 Antikörper) leads to a significant decrease in cell proliferation due to cell cycle arrest in the G1 phase.
Higher epithelial KCNN4 expression was closely correlated with advanced TNM (zeige ODZ1 Antikörper) stages and predicted a poor prognosis in patients with pancreatic ductal adenocarcinoma.
Here, the authors demonstrate that phosphorylation of His358 activates KCa3.1 by antagonizing copper-mediated inhibition of the channel.

Cow (Bovine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaktionspartner

Blood brain barrier endothelial cells exhibit KCa3.1 protein and activity.

Mouse (Murine) Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Interaktionspartner

Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 (zeige GJA4 Antikörper) and IK1 expression may contribute. nNOS (zeige NOS1 Antikörper) or iNOS (zeige NOS2 Antikörper) did not upregulate to compensate for decreased eNOS (zeige NOS3 Antikörper), and they had little involvement in vasomotor function.
The Intermediate-conductance calmodulin/calcium-activated K+ channels 3.1 (KCa3.1-/- knockout mice) significantly reduced corneal fibrosis and expression of pro-fibrotic marker genes, suggesting that KCa3.1 plays an important role corneal wound healing in vivo.
KCa3.1(-/-) mice exhibited significantly smaller infarct areas in a model of ischemic stroke.
KCa3.1(-/-) mice demonstrated normal behavioral responses in models of acute nociceptive, persistent inflammatory, and persistent neuropathic pain. However, their behavioral responses to noxious chemical stimuli such as formalin and capsaicin were increased. Accordingly, formalin-induced nociceptive behavior was increased in wild-type mice after administration of the KCa3.1 inhibitor TRAM (zeige TICAM2 Antikörper)-34.
SK4 activity is crucial for cell cycle control.
Following differentiation with LPS (zeige TLR4 Antikörper) or a combination of LPS (zeige TLR4 Antikörper) and IFN-gamma (zeige IFNG Antikörper) microglia exhibited high KV 1.3 current densities ( approximately 50 pA/pF at 40 mV) and virtually no KCa (zeige CSN3 Antikörper) 3.1 and Kir (zeige GEM Antikörper) currents, while microglia differentiated with IL-4 (zeige IL4 Antikörper) exhibited large Kir (zeige GEM Antikörper) 2.1 currents ( approximately 10 pA/pF at -120 mV). KCa (zeige CSN3 Antikörper) 3.1 currents were generally low
Deletion of KCa3.1 reduced astrogliosis and rescued memory loss induced by intrahippocampal Abeta1-42 peptide injection.
Dynamic coupling between TRPV4 (zeige TRPV4 Antikörper) and Ca(2 (zeige CA2 Antikörper)+)-activated SK1 (zeige SPHK1 Antikörper)/3 and IK1 K(+) channels plays a critical role in regulating the K(+)-secretory BK channel KCNMA1 (zeige KCNMA1 Antikörper) in kidney collecting duct cells.
Blocking KCa3.1 suppresses plaque instability in advanced stages of atherosclerosis by inhibiting macrophage polarization toward an M1 phenotype.
enhanced KCa (zeige CSN3 Antikörper) 3.1 activity may compensate for decreased nitric oxide signaling during vascular aging.

KCNN4 Antigen-Profil

Protein Überblick

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

Genbezeichner und Symbole assoziert mit KCNN4

potassium calcium-activated channel subfamily N member 4 (KCNN4) Antikörper
potassium calcium-activated channel subfamily N member 4 (Kcnn4) Antikörper
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (Kcnn4) Antikörper

hIKCa1 Antikörper
hKCa4 Antikörper
hSK4 Antikörper
IK1 Antikörper
IKCA1 Antikörper
KCa3.1 Antikörper
KCA4 Antikörper
mIKCa1 Antikörper
rKCNN4c Antikörper
rSK4 Antikörper
SK4 Antikörper
SKCas Antikörper

Bezeichner auf Proteinebene für KCNN4

intermediate conductance calcium-activated potassium channel protein 4 , intermediate-conductance calcium-activated potassium channel , intermediate conductance calcium-activated potassium channel protein 1 , potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 , intermediate conductance calcium-activated potassium channel protein 4-like , SKCa 4 , SKCa4 , putative Gardos channel , putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel , IK1 , KCa4 , SK4 , intermediate conductance K channel , intermediate-conductance Ca-activated K channel , potassium intermediate-small conductance calcium-activated channel subfamily N member 4

GENE ID	SPEZIES
397081	Sus scrofa
456098	Pan troglodytes
100379254	Cavia porcellus
100391934	Callithrix jacchus
100468357	Ailuropoda melanoleuca
100593199	Nomascus leucogenys
3783	Homo sapiens
65206	Rattus norvegicus
534591	Bos taurus
484464	Canis lupus familiaris
16534	Mus musculus

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Show all anti-Potassium Intermediate/small Conductance Calcium-Activated Channel, Subfamily N, Member 4 (KCNN4) Antikörper with Pubmed References