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PIGR is a member of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen PIGR Proteine (44) und PIGR Kits (29) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PIGR Primary Antibody für IHC, IHC (p) - ABIN4345568
Trevisi, Gandolfi, Priori, Messori, Colombo, Mazzoni, Lallès, Bosi: Age-related expression of the polymeric immunoglobulin receptor (pIgR) in the gastric mucosa of young pigs. in PLoS ONE 2013
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Mouse (Murine) Polyclonal PIGR Primary Antibody für ELISA - ABIN2000385
Kaetzel: Polymeric Ig receptor: defender of the fort or Trojan horse? in Current biology : CB 2001
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Mouse (Murine) Polyclonal PIGR Primary Antibody für ELISA - ABIN2000383
Shoji, Takahashi, Kurohane, Iwata, Matsuoka, Tsuruta, Sugino, Miyake, Suzuki, Imai: Recombinant Immunoglobulin A Specific for Influenza A Virus Hemagglutinin: Production, Functional Analysis, and Formation of Secretory Immunoglobulin A. in Viral immunology 2015
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Both pIgR and FcRn mRNA levels were significantly reduced in the duodenal mucosa during acute SHIV infection and in the jejunum and caecum during chronic SHIV/SIV infection.
We identified two SLN (zeige SLN Antikörper) genes (PIGR and TFAP2A (zeige TFAP2A Antikörper)) that provided high prognostic accuracy in SLN (zeige SLN Antikörper)-positive melanoma patients (AUC = 0.864). These two SLN (zeige SLN Antikörper) genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients.
pIgR may be involved in pancreatic ductal adenocarcinoma progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression.
RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1 (zeige PECAM1 Antikörper), whereas the choline binding protein PspC binds, but to a lower extent, only pIgR
A genome-wide trans-ethnic interaction study links the PIGR-FCAMR (zeige FCAMR Antikörper) locus to coronary atherosclerosis via interactions between genetic variants and residential exposure to traffic pollution.
The polymeric immunoglobulin receptor secretory component structure comprises five immunoglobulin-like domains (D1-D5) arranged as a triangle, with an interface between ligand-binding domains D1 and D5.
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.
Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.
These results demonstrate that SLPI (zeige SLPI Antikörper) down-regulates pIgR expression through the NF-kappaB (zeige NFKB1 Antikörper) signaling pathway by inhibiting degradation of IkappaBbeta (zeige NFKBIB Antikörper) protein.
Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.
the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (zeige STAT6 Antikörper) pathway activation.
This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.
pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88 (zeige MYD88 Antikörper).
pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Results reveal a novel Yes-EGFR (zeige EGFR Antikörper)-ERK (zeige EPHB2 Antikörper)-FIP5 signalling network for regulation of pIgA (zeige PIGA Antikörper)-pIgR transcytosis.
Blockade of transepithelial transport of dimeric IgA (zeige IgA Antikörper) in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA (zeige IgA Antikörper) concentration and decrease in nasal IgA (zeige IgA Antikörper) concentration.
Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.
Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA (zeige IgA Antikörper) and 6-fold less nasal IgA (zeige IgA Antikörper) antibodies than wild-type mice due to defective IgA (zeige IgA Antikörper) transport into mucosal tissues.
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells\; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
polymeric immunoglobulin receptor
, polymeric immunoglobulin receptor-like
, poly-Ig receptor
, polymeric IgA receptor
, hepatocellular carcinoma associated protein TB6
, hepatocellular carcinoma-associated protein TB6
, phosphatidylinositol glycan, class R
, poly-IG receptor