Polymerase (RNA) Mitochondrial (DNA Directed) Proteine (POLRMT)

POLRMT encodes a mitochondrial DNA-directed RNA polymerase. Zusätzlich bieten wir Ihnen POLRMT Antikörper (20) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte POLRMT POLRMT 299604  
POLRMT 5442 O00411
POLRMT 216151 Q8BKF1
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

POLRMT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Weitere Proteine zu Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) Interaktionspartnern

Human Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) Interaktionspartner

  1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined.

  2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia (zeige BCL11A Proteine).

  3. knock-down of MRPL12 (zeige MRPL12 Proteine) by RNA interference results in instability of POLRMT.

  4. Results show that polymorphisms at POLG2 (zeige POLG2 Proteine) and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.

  5. The results reveal the organization of TFAM (zeige TFAM Proteine), POLRMT and TFB2M (zeige TFB2M Proteine) around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.

  6. The results demonstrate that human TFAM (zeige TFAM Proteine) binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP.

  7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR (zeige PTH1R Proteine)) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs.

  8. Authors propose that POLRMT interacts directly with h-mtTFB1 (zeige TFB1M Proteine) in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity.

  9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension

  10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII)

Mouse (Murine) Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) Interaktionspartner

  1. we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.

  2. POLRMT recognizes promoter elements in a sequence specific manner; TFAM (zeige TFAM Proteine) induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition

POLRMT Protein Überblick

Protein Überblick

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes.

Genbezeichner und Symbole assoziert mit POLRMT

  • RNA polymerase mitochondrial (Polrmt)
  • polymerase (RNA) mitochondrial (DNA directed) L homeolog (polrmt.L)
  • polymerase (RNA) mitochondrial (DNA directed) (polrmt)
  • RNA polymerase mitochondrial (POLRMT)
  • polymerase (RNA) mitochondrial (DNA directed) (Polrmt)
  • 1110018N15Rik Protein
  • 4932416K13 Protein
  • APOLMT Protein
  • h-mtRPOL Protein
  • MTRNAP Protein
  • mtRPO Protein
  • MTRPOL Protein
  • POLRMT Protein
  • polrmt-a Protein
  • si:dkeyp-74c5.5 Protein
  • wu:fb73g10 Protein

Bezeichner auf Proteinebene für POLRMT

DNA-directed RNA polymerase, mitochondrial , polymerase (RNA) mitochondrial (DNA directed) , mitochondrial DNA-directed RNA polymerase , mtRPOL

299604 Rattus norvegicus
394312 Xenopus laevis
557066 Danio rerio
504757 Bos taurus
5442 Homo sapiens
216151 Mus musculus
Ausgewählte Anbieter für POLRMT Proteine (POLRMT)
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