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POLRMT encodes a mitochondrial DNA-directed RNA polymerase. Zusätzlich bieten wir Ihnen POLRMT Antikörper (20) und viele weitere Produktgruppen zu diesem Protein an.
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the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined.
Suggest targeting POLRMT as strategy for treating acute myeloid leukemia (zeige BCL11A Proteine).
knock-down of MRPL12 (zeige MRPL12 Proteine) by RNA interference results in instability of POLRMT.
Results show that polymorphisms at POLG2 (zeige POLG2 Proteine) and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.
The results reveal the organization of TFAM (zeige TFAM Proteine), POLRMT and TFB2M (zeige TFB2M Proteine) around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.
The results demonstrate that human TFAM (zeige TFAM Proteine) binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP.
Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR (zeige PTH1R Proteine)) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs.
Authors propose that POLRMT interacts directly with h-mtTFB1 (zeige TFB1M Proteine) in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity.
X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension
muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII)
we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.
POLRMT recognizes promoter elements in a sequence specific manner; TFAM (zeige TFAM Proteine) induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition
This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes.
DNA-directed RNA polymerase, mitochondrial
, polymerase (RNA) mitochondrial (DNA directed)
, mitochondrial DNA-directed RNA polymerase