Protein Überblick

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F- RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Genbezeichner und Symbole assoziert mit POLR3G

• polymerase (RNA) III (DNA directed) polypeptide G (Polr3g) Antikörper
• RNA polymerase III subunit G (POLR3G) Antikörper

• 2310047G20Rik Antikörper
• AV275904 Antikörper
• RPC7 Antikörper
• RPC32 Antikörper

Bezeichner auf Proteinebene für POLR3G

DNA-directed RNA polymerase III subunit G , DNA-directed RNA polymerase III subunit RPC7 , RNA polymerase III subunit C7 , DNA-directed RNA polymerase III 32 kDa polypeptide , RNA polymerase III 32 kDa subunit