Polymerase (DNA Directed), gamma 2, Accessory Subunit Proteine (POLG2)

POLG2 encodes the processivity subunit of the mitochondrial DNA polymerase gamma. Zusätzlich bieten wir Ihnen Polymerase (DNA Directed), gamma 2, Accessory Subunit Antikörper (42) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte POLG2 POLG2 303612  
POLG2 11232 Q9UHN1
Maus POLG2 POLG2 50776 Q9QZM2
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 2 bis 3 Tage
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POLG2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Interaktionspartnern

Human Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Interaktionspartner

  1. This is the first report of a patient with a homozygous mutation in POLG2 and with a clinical presentation of severe hepatic failure and mitochondrial depletion.

  2. Results show that polymorphisms at POLG2 and POLRMT (zeige POLRMT Proteine) increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.

  3. The authors describe the molecular characterization of a potential dominant POLG2 mutation (p.R369G) in a patient with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions.

  4. Data show that rs17650301 in POLG2 is a good candidate marker for UBC (zeige RPS27A Proteine) invasiveness in Japanese males.

  5. The biochemical analysis helps explain the pathogenesis of POLG2 mutations in mitochondrial disease.

  6. human pol gammaB exhibits a catalytic subunit- and substrate DNA-dependent dimerization.

  7. PolB (zeige POLB Proteine) gamma can bind double-stranded DNA and may play a role in DNA replication or repair

  8. Study represents the first structure-function analysis of the thumb subdomain in pol gamma (zeige POLG Proteine) and examines the consequences of mitochondrial disease mutations in this region.

  9. Both increased and decreased expression of POLGbeta altered nucleoid structure and precipitated a marked decrease in 7S DNA molecules, which form short displacement-loops on mitochondrial DNA.

Mouse (Murine) Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Interaktionspartner

  1. Our data indicate that Polg2 function is critical to mammalian embryogenesis and mtDNA replication, and that a single copy of Polg2 is sufficient to sustain life.

Polymerase (DNA Directed), gamma 2, Accessory Subunit (POLG2) Protein Überblick

Protein Überblick

This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.

Genbezeichner und Symbole assoziert mit POLG2

  • DNA polymerase gamma 2, accessory subunit (Polg2)
  • DNA polymerase gamma 2, accessory subunit (POLG2)
  • polymerase (DNA directed), gamma 2, accessory subunit (polg2)
  • polymerase (DNA directed), gamma 2, accessory subunit (Polg2)
  • polymerase (DNA directed), gamma 2, accessory subunit L homeolog (polg2.L)
  • HP55 Protein
  • im:7158733 Protein
  • mtpolb Protein
  • PEOA4 Protein
  • POLB Protein
  • POLG-BETA Protein
  • POLG2 Protein
  • POLGB Protein
  • si:ch211-157f15.3 Protein

Bezeichner auf Proteinebene für POLG2

DNA polymerase subunit gamma-2, mitochondrial , polymerase (DNA directed), gamma 2, accessory subunit , DNA polymerase subunit gamma-2, mitochondrial-like , DNA polymerase gamma accessory 55 kDa subunit , mitochondrial DNA polymerase accessory subunit , mitochondrial DNA polymerase subunit gamma-2 , mitochondrial DNA polymerase, accessory subunit , p55 , mitochondrial polymerase gamma 2 , mtPolB , polG-beta , polymerase, gamma 2

GENE ID SPEZIES
303612 Rattus norvegicus
417418 Gallus gallus
455266 Pan troglodytes
490910 Canis lupus familiaris
717856 Macaca mulatta
100029647 Monodelphis domestica
100064219 Equus caballus
100397872 Callithrix jacchus
100458861 Pongo abelii
100150674 Danio rerio
11232 Homo sapiens
50776 Mus musculus
505152 Bos taurus
398112 Xenopus laevis
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