Poly(rC) Binding Protein 2 Proteine (PCBP2)

The protein encoded by PCBP2 appears to be multifunctional. Zusätzlich bieten wir Ihnen PCBP2 Antikörper (63) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PCBP2 5094 Q15366
PCBP2 18521 Q61990
Ratte PCBP2 PCBP2 363005  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage

PCBP2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Am meisten referenzierte PCBP2 Proteine

  1. Human PCBP2 Protein expressed in HEK-293 Cells - ABIN2728353 : Školáková, Foldynová-Trantírková, Bednářová, Fiala, Vorlíčková, Trantírek: Unique C. elegans telomeric overhang structures reveal the evolutionarily conserved properties of telomeric DNA. in Nucleic acids research 2015 (PubMed)

Weitere Proteine zu Poly(rC) Binding Protein 2 (PCBP2) Interaktionspartnern

Human Poly(rC) Binding Protein 2 (PCBP2) Interaktionspartner

  1. PCBP2 expression was markedly increased in higher stages of glioblastoma compared with those in lower stages; further research suggested that PCBP2 upregulation was connected with poorer prognosis in patients with glioblastoma

  2. Double immunofluorescence for hnRNP E2 and TDP-43 (zeige TARDBP Proteine) showed most TDP-43 (zeige TARDBP Proteine) immunopositive dystrophic neuritis within frontal and temporal cortex, and the neuronal cytoplasmic inclusions seen in dentate gyrus granule cells, to contain hnRNP E2. Present findings indicate an association between TDP-43 (zeige TARDBP Proteine) and hnRNP E2 which might underlie the pathogenetic mechanism of Semantic Dementia Frontotemporal Lobar Degeneration.

  3. Data suggest that the interaction between PCBP2 and the 3'UTR of the ARHGDIA (zeige ARHGDIA Proteine) mRNA may induce a local change in RNA structure that favors subsequent binding of miR (zeige MLXIP Proteine)-151-5p and miR-16 (zeige GDE1 Proteine), thus leading to the suppression of ARHGDIA (zeige ARHGDIA Proteine) expression.

  4. To promote intracellular iron flux, an iron chaperone appears to be essential for receiving iron from heme catabolism. Data suggest that PCBP2 competes with CPR (zeige POR Proteine) for binding HO1 (zeige HMOX1 Proteine); PCBP2 K homology 3 domain is important for HO1 (zeige HMOX1 Proteine)/PCBP2 interaction; heme prompts HO1 (zeige HMOX1 Proteine)/CPR (zeige POR Proteine) multimer and decreases HO1 (zeige HMOX1 Proteine)/PCBP2 multimer. [PCBP2 = poly(rC) binding protein 2; CPR (zeige POR Proteine) = cytochrome P450 reductase (zeige POR Proteine); HO1 (zeige HMOX1 Proteine) = heme oxidase 1]

  5. BC200 RNA interacts with hnRNP E1 (zeige PCBP1 Proteine) and E2 mainly through its unique 3' C-rich domain.

  6. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  7. These results suggest that FPN1 (zeige SLC40A1 Proteine) exports iron received from the iron chaperone PCBP2. Therefore, it was found that PCBP2 modulates cellular iron export, which is an important physiological process.

  8. PCBP2 was overexpressed in esophageal squamous cell carcinoma tissues and cell lines. PCBP2 expression promoted proliferation of ESCC cells. We also found that reduced PCBP2 expression might induce ESCC cell apoptosis with increased cleaved caspase3 expression. Overall, our findings indicated that PCBP2 might be involved in the ESCC progression and be considered as a new treatment target in ESCC.

  9. High expression of PCBP2 may contribute to sorafenib resistance in hepatocellular carcinoma cells.

  10. our data indicate that miR (zeige MLXIP Proteine)-214 may function as tumor suppressor in glioma by targeting PCBP2

Mouse (Murine) Poly(rC) Binding Protein 2 (PCBP2) Interaktionspartner

  1. Study determined that PCBP2 specifically associates with components of this kinase cascade and regulates the activities of its downstream transcriptional coactivators.

  2. data suggest that PCBP2 regulates p73 (zeige ARHGAP24 Proteine) expression via mRNA stability and p73 (zeige ARHGAP24 Proteine)-dependent biological function in ROS (zeige ROS1 Proteine) production and cellular senescence.

  3. PCBP2 overexpression rescues the Meis1 (zeige MEIS1 Proteine) effects of Akt (zeige AKT1 Proteine)-mTOR (zeige FRAP1 Proteine) pathway and hypertrophy of cardiomyocytes.

  4. These data reveal that Pcbp1 (zeige PCBP1 Proteine) and Pcbp2 are individually essential for mouse embryonic development and have distinct impacts on embryonic viability and that Pcpb2 has a nonredundant in vivo role in hematopoiesis.

  5. PCBP2 knockdown promoted angiotensin II-induced hypertrophy (increase in cell size, protein synthesis and activation of fetal genes) of cardiomyocytes, while PCBP2 overexpression obtained oppose effects.

  6. Our analysis of PCBP1 (zeige PCBP1 Proteine) and PCBP2 expression demonstrates robust expression of these two proteins within the gastric epithelium with high concordance for both proteins in their cell-type specificities and intracellular distributions.

  7. This study demonstrates for the first time that alpha-CP2 functions as a transcriptional activator by binding to a single-stranded poly(C) sequence.

  8. This study provides evidence that PCBP2 and hnRNP A1 (zeige HNRNPA1 Proteine) bind to the 5' and 3' ends of the murine norovirus 1 viral RNA and contribute to RNA circularization, playing a role in the virus life cycle.

  9. PCBP2-AIP4 (zeige ITCH Proteine) axis defines a new signaling cascade for MAVS (zeige MAVS Proteine) degradation and 'fine tuning' of antiviral innate immunity.

Pig (Porcine) Poly(rC) Binding Protein 2 (PCBP2) Interaktionspartner

  1. These results indicated that Nsp1beta of porcine reproductive and respiratory syndrome virus is able to bind and interact with cellular PCBP2 strongly in both the infected cells and plasmid transfected cells.

  2. Overall, the results presented here point toward an important role for PCBP1 (zeige PCBP1 Proteine) and PCBP2 in regulating porcine reproductive and respiratory syndrome virus RNA synthesis via binding to viral nonstructural protein 1beta.

PCBP2 Protein Überblick

Protein Überblick

The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PCBP2

  • poly(rC) binding protein 2 (PCBP2)
  • poly(rC) binding protein 2 (Pcbp2)
  • poly(rC) binding protein 2 (pcbp2)
  • poly(rC) binding protein 2 L homeolog (pcbp2.L)
  • alphaCP-2 Protein
  • AW412548 Protein
  • fb36h02 Protein
  • hnRNP-E2 Protein
  • HNRNPE2 Protein
  • HNRPE2 Protein
  • Hnrpx Protein
  • PCBP2 Protein
  • PCBP3 Protein
  • wu:fb36h02 Protein
  • zgc:55964 Protein

Bezeichner auf Proteinebene für PCBP2

alpha-CP2 , heterogeneous nuclear ribonucleoprotein E2 , heterogenous nuclear ribonucleoprotein E2 , hnRNP E2 , poly(rC)-binding protein 2 , CBP , CTBP , heterogeneous nuclear ribonucleoprotein X , hnRNP X , putative heterogeneous nuclear ribonucleoprotein X , poly(rC) binding protein 2 , poly(rC) binding protein 3 , PolyrC-binding protein 2 , poly(rc)-binding protein 2 , heterogeneous nuclear ribonucleoprotein

5094 Homo sapiens
18521 Mus musculus
321844 Danio rerio
363005 Rattus norvegicus
399399 Xenopus laevis
420965 Gallus gallus
477596 Canis lupus familiaris
540653 Bos taurus
733863 Xenopus (Silurana) tropicalis
100194880 Salmo salar
100528911 Ictalurus punctatus
397665 Sus scrofa
100731593 Cavia porcellus
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