Plexin A2 Proteine (Plxna2)

Plxna2 encodes a member of the plexin-A family of semaphorin co-receptors. Zusätzlich bieten wir Ihnen Plexin A2 Antikörper (49) und Plexin A2 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Plxna2 5362 O75051
Plxna2 18845 P70207
Ratte Plxna2 Plxna2 289392  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Wheat germ Human GST tag 25 μg Anmelden zum Anzeigen 11 bis 12 Tage

Plxna2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Am meisten referenzierte Plexin A2 Proteine

  1. Human Plxna2 Protein expressed in Wheat germ - ABIN1315496 : Kunath, Delaroque, Szardenings, Neundorf, Straub: Sympathetic nerve repulsion inhibited by designer molecules in vitro and role in experimental arthritis. in Life sciences 2016 (PubMed)

Weitere Proteine zu Plexin A2 (Plxna2) Interaktionspartnern

Zebrafish Plexin A2 (Plxna2) Interaktionspartner

  1. used Sema6A (zeige SEMA6A Proteine)-deficient and PlxnA2-deficient zebrafish embryos in a microarray analysis to identify genes that were differentially expressed when this signaling pathway was disrupted.

  2. Sema6a (zeige SEMA6A Proteine) and Plxna2 have roles in promoting eye vesicle cohesion through mediating spatially regulated repulsion within the developing zebrafish eye

Human Plexin A2 (Plxna2) Interaktionspartner

  1. Data indicate that plexin A1 (zeige PLXNA1 Proteine)-4 (PLXNA1 (zeige PLXNA1 Proteine)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.

  2. although plexin-A4 (zeige PLXNA4 Proteine) overexpression restored Sema3A (zeige SEMA3A Proteine) signaling in plexin-A1 (zeige PLXNA1 Proteine)-silenced cells, it failed to restore Sema3B (zeige SEMA3B Proteine) signaling in plexin-A2-silenced cells.

  3. PLXNA2 upregulation contributes to TMPRSS2 (zeige TMPRSS2 Proteine):ERG (zeige ERG Proteine)-mediated enhancements of PC3c cell migration and invasion.

  4. PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot.

  5. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 (zeige BMP2 Proteine) signaling

  6. PLXNA2 polymorphisms show association with ankylosing spondylitis.

  7. in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.

  8. An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene.

  9. results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample

  10. PLXNA2 confers a varying genetic risk for schizophrenia among different populations.

Mouse (Murine) Plexin A2 (Plxna2) Interaktionspartner

  1. These findings implicate Semaphorin-6A (zeige SEMA6A Proteine) - Plexin-A2/Plexin-A4 (zeige PLXNA4 Proteine) interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.

  2. describe procedures for protein production and purification that we utilized in the crystallographic study of the mouse Plexin A2 (mPlxnA2) extracellular fragment, including the sema (zeige SEMA3B Proteine) domain

  3. Using time-lapse videomicroscopy we provide evidence that Sema6A (zeige SEMA6A Proteine)/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell

  4. Plexin A2 is expressed in both On and Off starburst amacrine cell.

  5. results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 (zeige BMP2 Proteine) signaling

  6. crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1 (zeige PLXNB1 Proteine)(1-2)-SEMA4D (zeige SEMA4D Proteine)(ecto (zeige TRIM33 Proteine)) and murine PlxnA2(1-4)-Sema6A (zeige SEMA6A Proteine)(ecto (zeige TRIM33 Proteine))), plus unliganded structures of PlxnA2(1-4) and Sema6A (zeige SEMA6A Proteine)(ecto (zeige TRIM33 Proteine))

  7. crystal structures of the semaphorin 6A (Sema6A (zeige SEMA6A Proteine)) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states

  8. This study demonstrated that Sema6B (zeige SEMA6B Proteine), another class 6 transmembrane semaphorin, is expressed in CA3 (zeige CA3 Proteine) and repels mossy fibers in a PlxnA4 (zeige PLXNA4 Proteine)-dependent manner in vitro.

  9. In plexin-A2-deficient mice many granule cells remained in the molecular layer; mouse chimera studies further suggested that plexin-A2 acts in a cell-autonomous manner.

  10. mutations in GATA6 (zeige GATA6 Proteine) are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C (zeige SEMA3C Proteine)-plexin A2 signaling

Plexin A2 (Plxna2) Protein Überblick

Protein Überblick

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.

Genbezeichner und Symbole assoziert mit Plexin A2 Proteine (Plxna2)

  • plexin A2 (PLXNA2)
  • plexin A2 (plxna2)
  • plexin-A2 (LOC100078346)
  • plexin A2 (Plxna2)
  • 2810428A13Rik Protein
  • AA589422 Protein
  • AW457381 Protein
  • mKIAA0463 Protein
  • OCT Protein
  • Plxn2 Protein

Bezeichner auf Proteinebene für Plexin A2 Proteine (Plxna2)

plexin-A2 , plexin A2 , plexin-A2-like , plexin 2 , semaphorin receptor OCT , transmembrane protein OCT , plex 2 , plexin-2

407770 Bos taurus
419857 Gallus gallus
490270 Canis lupus familiaris
561285 Danio rerio
713800 Macaca mulatta
100051646 Equus caballus
100078346 Ornithorhynchus anatinus
100144723 Xenopus (Silurana) tropicalis
100437578 Pongo abelii
100479692 Ailuropoda melanoleuca
100514595 Sus scrofa
100553072 Anolis carolinensis
100590667 Nomascus leucogenys
5362 Homo sapiens
18845 Mus musculus
289392 Rattus norvegicus
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