Pleckstrin Homology-Like Domain, Family A, Member 1 Proteine (PHLDA1)

PHLDA1 encodes an evolutionarily conserved proline-histidine rich nuclear protein. Zusätzlich bieten wir Ihnen PHLDA1 Antikörper (48) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PHLDA1 22822 Q8WV24
PHLDA1 21664 Q62392
PHLDA1 29380  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,129.50
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PHLDA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1) Interaktionspartnern

Human Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1) Interaktionspartner

  1. suggest a unique regulatory feature of PHLDA1 to inhibit the ErbB receptor oligomerization process and thereby control the activity of receptor signaling network.

  2. Data identified PHLDA1 as a novel p53 target with an ability to repress Akt. PHLDA1 has a so-called split PH domain divided into an N-terminal and a C-terminal portions and seems to be responsible for its localization to the plasma membrane and binding to phosphatidylinositol. In addition, PHLDA1 expression analysis suggests that PHLDA1 has a tumor suppressive function in breast and ovarian cancers.

  3. Our study negatively correlates expression of PHLDA1 and Aurora A in IMR-32 cells and sheds new light on functions of PHLDA1 in the neuroblastoma tumor cells, suggesting its role as a pro-apoptotic protein

  4. Suggest decreased expression of PHLDA1 may play an important role in tumor progression, and may become a new adjunct biomarker in the prognosis in gastric adenocarcinoma.

  5. Data suggest that high PHLDA1 expression is controlled through an ER-NFkappaB-miR-181 regulatory axis and may contribute to a poor clinical outcome in patients with ER+ breast tumors by enhancing stem-like properties in these tumors.

  6. PHLDA1 expression is a useful addition in differentiating trichoblastoma and basal cell carcinoma.

  7. A role for PHLDA1 as an apoptosis suppressor in oral cancer cells.

  8. Data show that downregulation of aurora A kinase by the therapeutic antibody is associated with decreased levels of MYCN protein in cytoplasm, and induced expression of PHLDA1 and P53 proteins.

  9. The follicular stem cell marker PHLDA1 (TDAG51) indicates that most basaloid tumors in nevus sebaceus are basal cell carcinomas and not trichoblastomas.

  10. PHLDA1 differentiates between desmoplastic trichoepithelioma and morpheaform basal cell carcinoma but shows variable staining in microcystic adnexal carcinoma.

  11. the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51

  12. crucial negative regulator and effector of Aurora A kinase in breast cancer

  13. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis

  14. The progressive loss of PHLDA1 expression in melanomas may play a role in deregulated cell growth and apoptosis resistance in these tumors.

  15. expression of TDAG51 in human T-cells does not correlate with activation-induced cell death

  16. TDAG51 plays an important role in the anti-apoptotic effects of IGF-I.

  17. TDAG51 locus shows an operon-like organization of two head-to-head oriented transcripts that are inversely regulated in T lymphocytes by a CpG-rich bidirectional promoter.

  18. Reduced PHLDA1 expression is important in breast cancer progression and could serve as useful prognostic marker of disease outcome.

  19. TDAG51 in patients with intractable epilepsy was significantly higher when compared with levels in the controls.

  20. The anti-estrogen ICI 182,780 (1 microM) inhibited PHLDA1 mRNA expression and completely abolished the effect of 10 nM 17beta-estradiol on PHLDA1 expression (P < 0.05), suggesting that PHLDA1 is regulated by estrogen via ER.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 1 (PHLDA1) Interaktionspartner

  1. The data presented herein demonstrate TDAG51 expression to be upregulated in damaged skeletal muscle and its absence attenuates the early phases of muscle regeneration.

  2. PHLDA1 plays a critical role in the development of progressive lung contusion and subsequent inflammation.

  3. These findings suggested that TDAG51 up-regulation is a dependent event during LPS-mediated proliferation and cell cycle progression, and which increase our understanding of the interaction mechanism between LPS and macrophages.

  4. The JAK2-ERK1/2-STAT3 pathway is an important signaling pathway for regulation of PHLDA1 expression.

  5. TDAG51 has a protective role in oxidative stress-induced cell death in mouse embryonic fibroblasts.

  6. Our results suggest that the balance between the cell survival and death signals mediated by HSP70 and TDAG51, respectively, may be disturbed by the altered expression of HSF1 during the progression of disease in this amyotropic lateral sclerosis model.

  7. TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and white adipose tissue.

  8. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis

  9. TDAG51 is induced by homocysteine, promotes detachment-mediated PCD, and contributes to the development of atherosclerosis observed in hyperhomocysteinemia

PHLDA1 Protein Überblick

Protein Überblick

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.

Genbezeichner und Symbole assoziert mit PHLDA1

  • pleckstrin homology like domain family A member 1 (PHLDA1)
  • pleckstrin homology like domain, family A, member 1 (Phlda1)
  • pleckstrin homology-like domain, family A, member 1 (Phlda1)
  • pleckstrin homology-like domain, family A, member 1 L homeolog (phlda1.L)
  • DT1P1B11 Protein
  • PHRIP Protein
  • Tdag Protein
  • TDAG51 Protein

Bezeichner auf Proteinebene für PHLDA1

PQ-rich protein , PQR protein , T-cell death-associated gene 51 protein , apoptosis-associated nuclear protein , pleckstrin homology-like domain family A member 1 , proline- and glutamine-rich protein , proline- and histidine-rich protein , proline-histidine rich protein , T-cell death associated

GENE ID SPEZIES
22822 Homo sapiens
21664 Mus musculus
29380 Rattus norvegicus
540135 Bos taurus
100036927 Xenopus laevis
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