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PKP3 encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Zusätzlich bieten wir Ihnen Plakophilin 3 Antikörper (93) und viele weitere Produktgruppen zu diesem Protein an.
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PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 (zeige DSC2 Proteine) levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.
Children with low 25-hydroxyvitamin D and TMEM16J (zeige ANO9 Proteine) rs7111432-AA or PKP3 rs10902158-GG polymorphisms were at increased risk for tuberculosis or death.
Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2 (zeige DSC2 Proteine)), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 (zeige DSC2 Proteine) participates in desmosome formation in absence of desmoglein 2 (DSG2 (zeige DSG2 Proteine)).
The results suggest that MMP7 (zeige MMP7 Proteine) over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.
reactive oxygen species (ROS (zeige ROS1 Proteine)) trigger the c-Src kinase (zeige CSK Proteine)-mediated tyrosine (Tyr (zeige TYR Proteine))-195 phosphorylation of PKP3.
These findings reveal Pkp3 as a coordinator of desmosome and adherens junction assembly and maturation through its functional association with Rap1.
cytoplasmic PKP1/3 are components of mRNA ribonucleoprotein particles and act as posttranscriptional regulators of gene expression.
Pemphigus vulgaris (zeige DSG3 Proteine) autoimmune globulin induces Src (zeige SRC Proteine)-dependent tyrosine-phosphorylation of PKP3 and its detachment from DSG3 (zeige DSG3 Proteine).
The study describes a new protein variant of the human PKP3 gene, namely PKP3b, which differs from the published PKP3a only at the amino-terminus by the splicing in of the newly identified exon 1b.
stratifin (zeige SFN Proteine) plays a role in regulating plakophilin-3 incorporation into the desmosomal plaque by forming a plakophilin-3 stratifin (zeige SFN Proteine) complex in the cytosol and thereby affecting desmosome dynamics in squamous epithelial cells.
data highlight a novel role for hematopoietic PKP3 in the regulation of both locally and systemically induced immune responses.
PKP3 gene down regulation is associated with bladder cancer invasion.
PKP3 plays a critical role in morphogenesis of HFs and shafts and in limiting inflammatory responses in the skin
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may act in cellular desmosome-dependent adhesion and signaling pathways.
, plakophilin 3b