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The protein encoded by PITPNB is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. Zusätzlich bieten wir Ihnen PITPNB Antikörper (65) und und viele weitere Produktgruppen zu diesem Protein an.
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Phosphatidylinositol and phosphatidylcholine (zeige SGMS2 Proteine) exchange activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum.
Role of PITPNB- not required for sphingomyelin trafficking
Data suggest that phosphatidylinositol transfer protein (PITP) beta is an essential housekeeping PITP in murine cells, whereas PITP alpha (zeige PITPNA Proteine) plays a far more specialized function in mammals.
The Golgi localization of phosphatidylinositol transfer protein beta requires the protein kinase C-dependent phosphorylation of serine
PITPbeta localizes predominantly to the trans-Golgi network (TGN) and that this localization is independent of the phospholipid-bound state of PITPbeta.
Mouse NIH3T3 fibroblast cells overexpressing phosphatidylinositol transfer protein beta (PI-TPbeta, SPIbeta cells) demonstrate a low rate of proliferation and a high sensitivity towards UV-induced apoptosis when compared with wtNIH3T3 cells.
Pitpnb expression is particularly robust in double cone cells of the zebrafish retina
The protein encoded by this gene is found in the cytoplasm, where it catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes.
phosphatidylinositol transfer protein, beta
, phosphotidylinositol transfer protein, beta
, phosphotidylinositol transfer protein
, phosphatidylinositol transfer protein beta isoform
, PtdIns transfer protein beta
, ptdInsTP beta
, PI-TP 36 kda isoform
, phosphatidylinositol-transfer protein 36 kDa isoform
, ptdIns transfer protein beta
, Pitp beta