Phosphoribosyl Pyrophosphate Amidotransferase Proteine (PPAT)

The protein encoded by PPAT is a member of the purine/pyrimidine phosphoribosyltransferase family. Zusätzlich bieten wir Ihnen PPAT Antikörper (72) und PPAT Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PPAT 5471 Q06203
PPAT 117544 P35433
Maus PPAT PPAT 231327  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

PPAT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus)

Weitere Proteine zu Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) Interaktionspartner

  1. DREF (zeige ZBED1 Proteine) binds directly upstream of Prat and the DRE (zeige SUFUH Proteine) sites associated with its activity are necessary for Prat expression

  2. Data show the presence of apoptosis at the cellular level in both ade2 (zeige PAICS Proteine) and Prat mutants, and the upregulated gene HtrA2 (zeige HTRA2 Proteine), which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.

  3. whereas Mod(Prat:bw)3-5 suppresses Prat in all stages and tissues examined for both sexes.

  4. Evidence suggests that Prat originated by gene duplication by retrotransposition of Prat2.

  5. Regulation of expression of prat in the adult eye was studied.

  6. Use of Prat and Prat2 double RNA interference causes more severe pupal lethal phenotypes and suggests that Prat and Prat2 have partially additive functions during Drosophila metamorphosis.

  7. Data show that the requirement for both Prat and Prat2 in Drosophila is not simply due to differences in protein function. Both genes have developed nonoverlapping patterns of expression, which correlate with their respective loss-of-function phenotypes.

Human Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) Interaktionspartner

  1. purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer

PPAT Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.

Genbezeichner und Symbole assoziert mit PPAT

  • phosphoribosyl pyrophosphate amidotransferase (PPAT)
  • phosphoribosyl pyrophosphate amidotransferase (Ppat)
  • phosphoribosyl pyrophosphate amidotransferase L homeolog (ppat.L)
  • phosphoribosyl pyrophosphate amidotransferase (ppat)
  • 5730454C12Rik Protein
  • AA408689 Protein
  • AA675351 Protein
  • AI507113 Protein
  • Atase Protein
  • C79945 Protein
  • GPAT Protein
  • im:6894693 Protein
  • PRAT Protein
  • si:dkeyp-117h8.5 Protein
  • wu:fb61f03 Protein
  • wu:fc28b09 Protein

Bezeichner auf Proteinebene für PPAT

amidophosphoribosyltransferase , glutamine PRPP amidotransferase , glutamine phosphoribosylpyrophosphatate amidotransferase , glutamine phosphoribosylpyrophosphate amidotransferase , phosphoribosyl pyrophosphate amidotransferase , amidophosphoribosyltransferase-like , GPAT , ATase , amidophosphoribosyltransferase-like protein

5471 Homo sapiens
100220341 Taeniopygia guttata
100348590 Oryctolagus cuniculus
100415443 Callithrix jacchus
117544 Rattus norvegicus
422743 Gallus gallus
231327 Mus musculus
398956 Xenopus laevis
611407 Canis lupus familiaris
509652 Bos taurus
100730194 Cavia porcellus
572027 Danio rerio
100053805 Equus caballus
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