Phosphoglycerate Mutase Family Member 5 Proteine (PGAM5)

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Zusätzlich bieten wir Ihnen PGAM5 Antikörper (10) und PGAM5 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PGAM5 192111 Q96HS1
PGAM5 72542 Q8BX10
PGAM5 288731 Q562B5
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Top PGAM5 Proteine auf antikoerper-online.de

Showing 7 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,718.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,759.17
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,762.83
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Hefe Fruchtfliege His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,762.83
Details

PGAM5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Phosphoglycerate Mutase Family Member 5 (PGAM5) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Phosphoglycerate Mutase Family Member 5 (PGAM5) Interaktionspartner

  1. The authors show that developmental mitochondrial unfolded protein response is necessary and sufficient to extend Drosophila lifespan, and identify Phosphoglycerate Mutase 5 (PGAM5) as a mediator of this response. Developmental mitochondrial stress leads to activation of FoxO, via Apoptosis Signal-regulating Kinase 1 (ASK1) and Jun-N-terminal Kinase (JNK).

  2. the mushroom body may possess an apoptosis-dependent toxic function, the suppression of which by dPGAM5 appears to be crucial for heat shock resistance.

  3. PGAM5 negatively regulates the PINK1 pathway related to maintenance of the mitochondria.

Human Phosphoglycerate Mutase Family Member 5 (PGAM5) Interaktionspartner

  1. Damaged mitochondria may induce replenishment of the mitochondrial pool by cell-intrinsic activation of Wnt signaling via the Pgam5-beta-catenin axis.

  2. suggests that PGAM5 senses mitochondrial dysfunction in the inner mitochondrial membrane and serves as a signalling intermediate that regulates the cellular response to mitochondrial stress upon its cleavage and release from mitochondria

  3. An intact complex of PGAM5-KEAP1-Nrf2 preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity.

  4. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells.

  5. Results indicate that a multiprotein complex including PGAM5, Bax and Drp1 proteins specifically formed during intrinsic apoptosis induction.

  6. Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.

  7. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy.

  8. Dephosphorylation of FUNDC1 by PGAM5 induces mitophagy.

  9. PGAM5 is proteolytically processed, accumulates in the cytosol during apoptosis, and sensitizes cells to death.

  10. Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

  11. Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways.

  12. The N terminus of the PGAM5 protein contains a conserved NXESGE motif that binds to the substrate binding pocket in the Kelch domain of Keap1.

  13. Results suggest that this member of the PGAM family has crossed over from small molecules to protein substrates and been adapted to serve as a specialized activator of ASK1.

Mouse (Murine) Phosphoglycerate Mutase Family Member 5 (PGAM5) Interaktionspartner

  1. Damaged mitochondria may induce replenishment of the mitochondrial pool by cell-intrinsic activation of Wnt signaling via the Pgam5-beta-catenin axis.

  2. melatonin treatment inhibited the Ripk3-PGAM5-CypD-mPTP cascade and thus reduced cellular necroptosis, conferring a protective advantage to the endothelial system in IR stress.

  3. findings suggest that HO-1 protects against I/R-induced hepatic injury via regulation of mitochondrial QC by PGAM5 signaling.

  4. Taken together, our findings provide evidence that NBP can attenuate the progression of EAE by suppressing PGAM5-induced necroptosis and inflammation in microglia and represents a new therapeutic strategy for treating autoimmune diseases.

  5. PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells.

  6. Results revealed that RIPK1 and PGAM5 function independently to exert optimal control of Leishmania replication in the host.

  7. Our data demonstrate for the first time that PGAM5 plays an indispensable role in the pathogenesis of ConA-induced liver injury.

  8. we also found that Pgam5-deficient mice are resistant to high-fat-diet-induced obesity. Our study uncovered that PGAM5 is involved in the whole-body metabolism in response to stresses that impose metabolic challenges on mitochondria.

  9. Our results revise the former proposal that PGAM5 acts downstream of RIP1/RIP3 to mediate necroptosis. Instead, PGAM5 protects cells from necroptosis by independently promoting mitophagy.

  10. PGAM5 is a novel regulator of inflammasome and caspase 1 activity that functions independently of RIPK3.

  11. Results identify a crucial role for RIPK3-PGAM5-Drp1/NFAT signalling in NKT cell activation, and further suggest that RIPK3-PGAM5 signalling may mediate crosstalk between mitochondrial function and immune signalling.

  12. Loss of PGAM5 disables PINK1-mediated mitophagy in vitro and leads to dopaminergic neurodegeneration and mild dopamine loss in vivo causing a Parkinson's-like movement disorder.

  13. Data indicate that phosphoglycerate mutase 5 (PGAM5) contains an N-terminal WDXNWD motif required for multimerization and maximal phosphatase activity.

  14. Experimental data indicate that the two splice variants of the mitochondrial protein phosphatase PGAM5 are at the convergent point of multiple necrosis pathways.

Xenopus laevis Phosphoglycerate Mutase Family Member 5 (PGAM5) Interaktionspartner

  1. Pgam5 is essential for head formation, and for establishing and maintaining the Wnt/beta-Catenin signaling gradient that patterns the anterior-posterior body axis. We show that Pgam5 interacts with Dishevelled2 and that Dishevelled2 is a substrate of Pgam5.

PGAM5 Protein Überblick

Protein Überblick

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression (By similarity).

Genbezeichner und Symbole assoziert mit PGAM5

  • Phosphoglycerate mutase 5 (Pgam5)
  • PGAM family member 5, mitochondrial serine/threonine protein phosphatase (PGAM5)
  • phosphoglycerate mutase family member 5 (Pgam5)
  • PGAM family member 5, mitochondrial serine/threonine protein phosphatase (Pgam5)
  • PGAM family member 5, serine/threonine protein phosphatase, mitochondrial S homeolog (pgam5.S)
  • PGAM family member 5, serine/threonine protein phosphatase, mitochondrial (pgam5)
  • 2610528A17Rik Protein
  • BXLBV68 Protein
  • CG14816 Protein
  • Dmel\\CG14816 Protein
  • dPGAM5 Protein
  • EG:63B12.4 Protein
  • PGAM5 Protein
  • RGD1312028 Protein
  • si:dkey-69p22.1 Protein
  • wu:fb39f09 Protein
  • wu:fj34f06 Protein
  • zgc:92057 Protein
  • zgc:112041 Protein

Bezeichner auf Proteinebene für PGAM5

CG14816-PA , Pgam5-PA , phosphoglycerate mutase 5 , Bcl-XL-binding protein v68 , serine/threonine-protein phosphatase PGAM5, mitochondrial , fb39f09

GENE ID SPEZIES
31143 Drosophila melanogaster
192111 Homo sapiens
72542 Mus musculus
288731 Rattus norvegicus
398484 Xenopus laevis
492357 Danio rerio
Ausgewählte Anbieter für PGAM5 Proteine (PGAM5)
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