Phosducin Proteine (PDC)

Human Phosducin (PDC) Interaktionspartner

1. Phosducin regulates secretory activity in TT line of thyroid parafollicular C cells.

2. Data suggest that phosducin rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension.

3. identification of Pdc as a gene for stress-induced hypertension offers new insights into the relationship between sympathetic nervous system activation, blood pressure regulation and genetic factors

4. Data suggest that the existence of a common epitope on the molecules of phosducin and beta-actin may reflect a topological similarity of a small region of their surfaces.

5. Candidate gene-based association studies in 2 different populations revealed several SNPs in the PDC gene to be associated with stress-dependent blood pressure phenotypes.

6. Phosducin mutations are not a major cause of dominant or recessive retinitis pigmentosa, Leber congenital amaurosis, or cone-rod degeneration.

7. SUMO-1 controls the protein stability and the biological function of phosducin.

Mouse (Murine) Phosducin (PDC) Interaktionspartner

1. the role of phosducin at the rod-to-rod bipolar cell (RBC) synapse

2. A major regulatory component responsible for setting the sensitivity of signal transmission between photoreceptors and ON-bipolar cells is confined to photoreceptors and that phosducin participates in the underlying molecular mechanism.

3. Pdc-/- mice displayed exaggerated increases in blood pressure in response to post-operative stress.

4. data suggest that phosducin action is based on the reduction of transducin affinity to the membranes of rod outer segments, achieved by keeping the transducin beta gamma subunits apart from the alpha subunit

5. The increased retinal degeneration 1 phosducin phosphorylation coincided with increased activation of calcium/calmodulin-activated protein kinase II, which is known to utilize phosducin as a substrate.

6. phosducin has a role in regulating signaling in the rod outer segment compartment and there are distinct functions for phosphorylation sites 54 and 71

7. Phosducin does not contribute to adaptation mechanisms of the outer segment by dynamically controlling heterotrimer availability, but is necessary for maintaining normal transducin expression and therefore normal flash sensitivity in rods.

8. Dopamine and other light-dependent processes cooperatively regulate the diurnal rhythm of phosducin phosphorylation. Dopamine release in response to light and circadian clocks drives daily rhythms of protein phosphorylation in photoreceptor cells.

Cow (Bovine) Phosducin (PDC) Interaktionspartner

1. Transducin betagamma is a substrate of the ubiquitin-proteasome pathway and is protected following the light-dependent dissociation of transducin alphabetagamma by phosducin

2. results suggest a pivotal role of Ser-54 and Ser-73 phosphorylation in determining the interactions of phosducin with its binding partner G protein beta gamma dimer