Persephin Proteine (PSPN)

Human Persephin (PSPN) Interaktionspartner

1. Results suggested that PSPN is a possible key regulator of oral squamous cell carcinoma (OSCC) progression via PSPN-RET-mitogen-activated protein kinase activation and that PSPN overexpression may have diagnostic potential for OSCC.

2. Results identify persephin, a GDNF family member, as a novel ligand for GFRalpha1/RET receptor complex.

3. Persephin/GFRalpha4 is unable to recruit RET protein into lipid rafts.

4. The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons.

5. No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients.

Mouse (Murine) Persephin (PSPN) Interaktionspartner

1. Mice lacking Pspn by homologous recombination show normal development and behavior, but are hypersensitive to cerebral ischemia.

2. TGF-beta with neurturin and persephin are required for the induction of dopaminergic neurons, whereas GDNF is required for regulating and/or maintaining a differentiated neuronal phenotype